Tropane alkaloids

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General tropane molecule
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Tropane alkaloids are a class of chemicals that include compounds with psychoactive effects.

Chemistry

Tropane alkaloids are molecules which contain a substituted tropane ring in their structure. Tropane is a nitrogen-containing bicyclic organic molecule which consists of a piperidine and pyrrolidine ring fused at carbons R1 and R5 along with an additional methyl substitution at RN. Tropane alkaloids are commonly substituted at R3 with an ether bridge (as seen in scopolamine, atropine, hyoscyamine, and cocaine).

Pharmacology

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Tropane alkaloids are mostly anti-cholinergics (antagonistic action on acetylcholine receptors) or stimulants (prevention of dopamine reuptake).

Examples

Tropane alkaloids are seen throughout organic chemistry and include psychoactive and anaesthetic compounds.

Anticholinergic drugs:

Stimulant drugs:

See also

References

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