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Irritability is medically recognized as the pervasive and sustained emotional state of being easily annoyed and provoked to anger.[1] It may be expressed outwardly in the cases of violence towards others, or directed inwards towards oneself in the form of self-harm.[2]

This effect, especially when strong, can sometimes cause violent or aggressive outbursts in a small subset of people who may be predisposed to it. The chances of somebody responding in such a way differs wildly between people and depends on how susceptible an individual is to irritability and how well they cope with it. It is also worth noting that this typically only affects those who were already susceptible to aggressive behaviours. However, regardless of the person, this effect results in a lower ability to tolerate frustrations, negative stimuli, and other people. A person undergoing this effect may be prone to lashing out at others, fits of anger, or other behaviours that would be uncharacteristic for them sober.

Irritability is often accompanied by other coinciding effects such as anxiety, paranoia, and ego inflation. It is most commonly induced during the after effects of heavy dosages of stimulant compounds, such as cocaine, methamphetamine,[3] and methylphenidate.[4] However, it can be a withdrawal symptom of almost any substance, and can to a lesser extent present itself during alcohol intoxication.[5]

Psychoactive substances

Compounds within our psychoactive substance index which may cause this effect include:

... further results

Experience reports

Annectdotal reports which describe this effect with our experience index include:

See also

External links


  1. "Glossary of Technical Terms". Diagnostic and statistical manual of mental disorders (5th ed.): 824–5. 2013. doi:10.1176/appi.books.9780890425596.GlossaryofTechnicalTerms. 
  2. Snaith, R. P.; Constantopoulos, A. A.; Jardine, M. Y.; McGuffin, P. (1978). "A clinical scale for the self-assessment of irritability". The British Journal of Psychiatry. 132 (2): 164–171. doi:10.1192/bjp.132.2.164. ISSN 0007-1250. 
  3. Sommers, Ira; Baskin, Deborah; Baskin-Sommers, Arielle (2006). "Methamphetamine use among young adults: Health and social consequences". Addictive Behaviors. 31 (8): 1469–1476. doi:10.1016/j.addbeh.2005.10.004. ISSN 0306-4603. 
  4. Ahmann, P. A., Waltonen, S. J., Olson, K. A., Theye, F. W., Van Erem, A. J., LaPlant, R. J. (June 1993). "Placebo-controlled evaluation of Ritalin side effects". Pediatrics. 91 (6): 1101–1106. ISSN 0031-4005. 
  5. Norström, Thor; Pape, Hilde (2010). "Alcohol, suppressed anger and violence". Addiction. 105 (9): 1580–1586. doi:10.1111/j.1360-0443.2010.02997.x. ISSN 0965-2140.