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Summary sheet: 2C-E
Chemical Nomenclature
Common names 2C-E, "Eternity"[1], "Aquarust"[1]
Substitutive name 2,5-Dimethoxy-4-ethylphenethylamine
Systematic name 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 2 - 5 mg
Light 5 - 10 mg
Common 10 - 15 mg
Strong 15 - 30 mg
Heavy 30 mg +
Total 6 - 10 hours
Onset 15 - 45 minutes
Come up 1 - 2 hours
Peak 3 - 5 hours
Offset 2 - 3 hours
After effects 6 - 24 hours

Threshold 1 mg
Light 1 - 4 mg
Common 4 - 7 mg
Strong 7 - 14 mg
Heavy 14 mg +
Onset 1 - 2 minutes
Peak 2 - 4 hours
Offset 1 - 2 hours
After effects 2 - 4 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


2,5-Dimethoxy-4-ethylphenethylamine (commonly known as 2C-E, or colloquially as "Aquarust"[1] and "Eternity"[1]) is a psychedelic substance of the phenethylamine class that produces potent psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.

2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977[2] and documented in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[3] It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. The general body of anecdotal reports tend to characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic notorious for its strong visuals and significant "body load".

2C-E began to appear in drug seizures around 2004.[4] While primarily distributed online as a research chemical, it is also sometimes distributed on the street as 'mescaline' or 'synthetic mescaline'. Users are advised to note the economic non-viability of retailing mescaline, which lacks the material potency and profitability to distribute in pill or gel-cap form.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-E, and it has a limited history of human use. Today, it is used for both recreational and entheogenic purposes. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with hallucinogens. It is highly advised to approach this very powerful, dose-sensitive hallucinogenic substance with the proper amount of precaution and harm reduction practices if using it.


2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-E contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.[5]


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Further information: Serotonergic psychedelic

2C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

Subjective effects

The effects listed below are based on the subjective effect index, which is based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will rarely (if ever) occur all at once but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects

Visual effects

Cognitive effects

Multi-sensory effects

Combinational effects

  • Cannabis - When used in combination with cannabis, both the visual and cognitive effects of 2C-E can be intensified and extended with extreme efficiency. This should be used with extreme caution if one is not experienced with psychedelics as this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of 2C-E have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis.
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 2C-E are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. Additionally, users should be aware that there are reasons to believe that this combination may result in unforeseen neurotoxic effects, so a strong sense of caution and independent research are highly advised if one decides to experiment with this combination.[citation needed]
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, typically considered to be safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically distressing manner.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an 2C-E trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between these substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-E is a research chemical with a limited history of human usage.

Anecdotal reports suggest that there are no negative health effects attributed to simply trying this substance by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance so as to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

Although no formal studies have been conducted, it is not unreasonable to assume that like psychedelics in general, 2C-E is not habit-forming and that the desire to use it can actually decrease with use.

Tolerance to the effects of 2C-E are built almost immediately after ingestion. After that, it takes about 1-2 days for the tolerance to be reduced to half and 2-4 days to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with all psychedelics but not evenly, meaning that after the consumption of 2C-E, some psychedelics will have significant reduced effects while some others will only be slighly affected.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when taken with other substances. The following lists some known dangerous combinations, but cannot be guaranteed to include all of them. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

  • Lithium - Lithium is commonly prescribed in the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis has an unexpectedly strong and unpredictable synergy with the effects of psychedelics. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid over intake.
  • Stimulants (Amphetamine, cocaine, methylphenidate, ...) - Stimulants affect many parts of the brain and alter dopaminergic function. Combined with psychedelics, stimulation can turn into severe anxiety, panic, thought loops, and paranoia. This interaction may result in an elevated risk of mania and psychosis.[citation needed]
  • Tramadol - Tramadol lowers the seizure threshold[6] and psychedelics may act as triggers for seizures in susceptible individuals.[citation needed]

Legal status

  • Austria: 2C-E is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[7]
  • Canada: 2C-E would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[8]
  • China: As of October 2015 2C-E is a controlled substance in China.[9]
  • Denmark: 2C-E is a Schedule I drug.[citation needed]
  • Finland: The possession, production and sale is illegal.[citation needed]
  • Germany: On December 13, 2014 2C-E was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[10]
  • Israel: Possession, production and sale is illegal.[citation needed]
  • Latvia: 2C-E is a Schedule I controlled substance.[11]
  • New Zealand: 2C-E is a Class C drug.[citation needed]
  • Sweden: 2C-E is a Schedule I drug.[citation needed]
  • Switzerland: Possession, production and sale is illegal.[12]
  • United Kingdom: 2C-E is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[13]
  • United States: 2C-E is a Schedule I drug.[14]

See also

External links



  1. 1.0 1.1 1.2 1.3 https://pubchem.ncbi.nlm.nih.gov/compound/2C-E#section=Synonyms
  2. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
  3. Shulgin, A., & Shulgin, A. (1991). Read #24 2C-E | PiHKAL  · info. Retrieved Jan 22, 2018.
  4. "2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 (Erowid.org) | https://erowid.org/library/periodicals/microgram/microgram_2004-11.pdf
  5. http://isomerdesign.com/PiHKAL/read.php?id=24
  6. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089
  7. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  8. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
  9. China Food and Drug Administration. (2017, April 10). 关于印发《非药用类麻醉药品和精神药品列管办法. Retrieved from http://www.buzzle.com
  10. Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm
  11. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  12. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  13. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made
  14. http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf