2C-E

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Summary sheet: 2C-E
2C-E
Molecular structure of 2C-E
2C-E.svg
Chemical Nomenclature
Common names 2C-E, "Eternity"[1], "Aquarust"[1]
Substitutive name 2,5-Dimethoxy-4-ethylphenethylamine
Systematic name 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 2 - 5 mg
Light 5 - 10 mg
Common 10 - 15 mg
Strong 15 - 30 mg
Heavy 30 mg +
Duration
Total 6 - 10 hours
Onset 15 - 45 minutes
Come up 1 - 2 hours
Peak 3 - 5 hours
Offset 2 - 3 hours
After effects 6 - 24 hours



Insufflated
Dosage
Threshold 1 mg
Light 1 - 4 mg
Common 4 - 7 mg
Strong 7 - 14 mg
Heavy 14 mg +
Duration
Onset 1 - 2 minutes
Peak 2 - 4 hours
Offset 1 - 2 hours
After effects 2 - 4 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2,5-Dimethoxy-4-ethylphenethylamine (also known as 2C-E, or colloquially as "Aquarust"[1] and "Eternity"[1]) is a potent synthetic psychedelic of the phenethylamine chemical class. It produces a highly dose-sensitive array of psychedelic effects comparable to those produced mescaline or other potent members of the 2C-x family when administered.

2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977.[2] and was documented in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). It was rated as a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. 2C-E began to appear in drug seizures around 2004[3].

Overall, anecdotal reports tend to characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic known for its strong visuals and intense "body load". The majority of reports on the effects produced by this substance indicate that it is likely overly challenging for those who are not already extensively experienced with hallucinogens, particularly potent psychedelics. Therefore it is highly advised to approach this very powerful, dose-sensitive hallucinogenic substance with the proper amount of precaution, preparation, and harm reduction practices if one chooses to use it.

History and culture

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Chemistry

2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-E contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.[4]

Pharmacology

Further information: Serotonergic psychedelic

2C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects
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Visual effects
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Cognitive effects
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Multi-sensory effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Combinations

  • Cannabis - When used in combination with cannabis, both the visual and cognitive effects of 2C-E can be intensified and extended with extreme efficiency. This should be used with extreme caution if one is not experienced with psychedelics as this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of LSD have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis.
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 2C-E are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. Additionally, users should be aware that there are reasons to believe that this combination may result in unforeseen neurotoxic effects, so a strong sense of caution and independent research are highly advised if one decides to experiment with this combination.[citation needed]
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, typically considered to be safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically distressing manner.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSD trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between these substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-E is a research chemical with very little history of human usage. Anecdotal evidence from those within the community who have tried 2C-E suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose.

Tolerance and addiction potential

2C-E is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-E are built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 7-10 days to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-E all psychedelics will have a reduced effect.

Dangerous interactions

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Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legality

  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[6]
  • Denmark: 2C-E is a Schedule I drug.[citation needed]
  • Finland: The possession, production and sale is illegal.[citation needed]
  • Israel: Possession, production and sale is illegal.[citation needed]
  • New Zealand: 2C-E is a Class C drug.[citation needed]
  • Sweden: 2C-E is a Schedule I drug.[citation needed]
  • Switzerland: Possession, production and sale is illegal.[7]
  • United Kingdom: 2C-E is a Class A drug.[citation needed]
  • United States: 2C-E is a Schedule I drug.[8]
  • Germany: On December 13, 2014 2C-E was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[9]
  • Latvia: 2C-E is a Schedule I controlled substance.[10]
  • China - As of October 2015 2C-E is a controlled substance in China.[11]
  • Canada: 2C-E would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[12]

See also

External links

References

  1. 1.0 1.1 1.2 1.3 https://pubchem.ncbi.nlm.nih.gov/compound/2C-E#section=Synonyms
  2. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
  3. "2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 (Erowid.org) | https://erowid.org/library/periodicals/microgram/microgram_2004-11.pdf
  4. http://isomerdesign.com/PiHKAL/read.php?id=24
  5. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  6. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  7. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  8. http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf
  9. Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm
  10. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  11. China Food and Drug Administration. (2017, April 10). 关于印发《非药用类麻醉药品和精神药品列管办法. Retrieved from http://www.buzzle.com
  12. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28