Disinhibition is medically recognized as an orientation towards immediate gratification, leading to impulsive behavior driven by current thoughts, feelings, and external stimuli, without regard for past learning or consideration of future consequences. This is usually manifested through recklessness, poor risk assessment, and a disregard for social conventions.
At its lower levels of intensity, disinhibition can allow one to overcome emotional apprehension and suppressed social skills in a manner that is moderated and controllable for the average person. This can often prove useful for those who suffer from social anxiety or a general lack of self-confidence.
However, at its higher levels of intensity, the disinhibited individual may be completely unable to maintain any semblance of self-restraint, at the expense of politeness, sensitivity, or social appropriateness. This lack of constraint can be negative, neutral, or positive depending on the individual and their current environment.
Disinhibition is often accompanied by other coinciding effects such as amnesia and anxiety suppression in a manner which can further decrease the person's observance of and regard for social norms. It is most commonly induced under the influence of moderate dosages of GABAergic depressants, such as alcohol, benzodiazepines, phenibut, and GHB. However, it may also occur under the influence of certain stimulants, entactogens, and dissociatives.
Compounds within our psychoactive substance index which may cause this effect include:
Annectdotal reports which describe this effect with our experience index include:
- Experience: 36mg 4-AcO-DiPT - Truly, one for the psychedelic animals among us
- Experience:100 mg- Actually Lifechanging
- Experience:20mg Etizolam - Smoking Etizolam
- Experience:24 mg Alprazolam - Into the Void
- Experience:260 mg Ketamine (insufflated) - Lost in Paisley
- Experience:3-MeO-PCP - Extreme psychosis
- Experience:3-MeO-PCP, LSD, Clonazolam, and Amphetamine - Excessive Amounts and Excessive Confusion
- Experience:3mg Etizolam - A Comedown Drug
- Experience:400mg and 300mg of fluorophenibut
- Experience:60mg Zolpidem - A Delirious Adventure
- Experience:Clonazolam + 2-methyl-AP-237 (unknown dosage) - Cardiac arrest
- Experience:DXM & DPH in combination
- Experience:Zopiclone hppd?
- Responsible use
- Subjective effects index
- Psychedelics - Subjective effects
- Dissociatives - Subjective effects
- Deliriants - Subjective effects
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- Ando, Romeo D.; Benko, Anita; Ferrington, Linda; Kirilly, Eszter; Kelly, Paul A.T.; Bagdy, Gyorgy (2006). "Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test". Neuropharmacology. 50 (7): 884–896. doi:10.1016/j.neuropharm.2005.12.010. ISSN 0028-3908.
- Lissek, Silke; Güntürkün, Onur (2003). "Dissociation of Extinction and Behavioral Disinhibition: The Role of NMDA Receptors in the Pigeon Associative Forebrain during Extinction". The Journal of Neuroscience. 23 (22): 8119–8124. doi:10.1523/JNEUROSCI.23-22-08119.2003. ISSN 0270-6474.