2-FMA

From PsychonautWiki
(Redirected from 2fma)
Jump to: navigation, search
Summary sheet: 2-FMA
2-FMA
Molecular structure of 2-FMA
2-FMA.svg
Chemical Nomenclature
Common names 2-FMA
Substitutive name 2-Fluoromethamphetamine
Systematic name (RS)-1-(2-Fluorophenyl)-N-methylpropan-2-amine
Class Membership
Psychoactive class Stimulant
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 5 - 10 mg
Light 10 - 20 mg
Common 20 - 40 mg
Strong 40 - 65 mg
Heavy 65 mg +
Duration
Total 7 - 9 hours
Onset 20 - 60 minutes
Come up 15 - 40 minutes
Peak 2.5 - 4 hours
Offset 2 - 3 hours
After effects 4 - 12 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2-Fluoromethamphetamine (2-FMA) is a synthetic ring-substituted fluorinated amphetamine compound that is commonly reported to produce classical stimulant effects such as stimulation, thought acceleration, focus and motivation enhancement when administered. It has been compared to lisdexamfetamine (Vyvanse) in its duration, potency and efficacy as a study aid or productivity enhancer.[1]

2-FMA is one member in a series of modern designer fluorinated amphetamine analogs that includes synthetic compounds like 2-FA, 3-FA, 3-FEA and 4-FA which are known for their range of central nervous system stimulation and euphoria-producing effects, some of which have been gaining popularity as research chemical substitutes for traditional street stimulants.[citation needed]

A substantial increase in negative effects like high blood pressure and increased heart rate is often reported for dosages above the heavy dosage range.

2-FMA is commonly taken either orally or via insufflation as it has been reported to be highly unpleasant to vaporize compared to its parent compound. Despite its popularity as a research chemical study aid, little is known about any toxicity that may accompany its long-term use as a substitute for prescription stimulants.

2-FMA has yet to be documented being sold on the streets and is instead typically sold by online vendors as a grey market research chemical.[2][3]

Chemistry

2-Fluoromethamphetamine (2-FMA) is a synthetic molecule of the substituted amphetamine class. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα (i.e., amphetamines are alpha-methylated phenethylamines). 2-FMA contains a methyl group bound to the terminal amine RN of the amphetamine core, a substitution it shares with methamphetamine.

2-FMA is the 2-position fluorinated analog of methamphetamine and the N-methylated homolog of 2-FA (2-fluoroamphetamine).

Pharmacology

Although 2-FMA has not been formally studied on the same level as traditional amphetamines, it is safe to assume that just like other substituted amphetamines, it most likely acts as both a dopamine and norepinephrine releasing agent. This means it effectively increases the levels of the norepinephrine and dopamine in the brain by binding to and partially blocking the transporter proteins that normally remove them from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.

Subjective effects

In comparison to other substituted amphetamines, 2-FMA is reported to be relatively free of side effects such as nausea, high blood pressure, anxiety and an uncomfortable offset ("comedown"). It is considered to be a functional psychoactive substance for performing general productivity tasks in a manner that is similar to dextroamphetamine or lisdexamfetamine (Vyvanse). However, at higher doses, it typically loses its productivity and attention-enhancing effects and begins to take on a recreational character due to the distracting euphoria that can result.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects
Child.svg

Visual effects
Eye.svg

Cognitive effects
User.svg

After effects
Aftereffects (3).svg

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2-FMA use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2-FMA has a very limited history of human usage. Anecdotal evidence from people who have tried 2-FMA within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with other stimulants, the chronic use of 2-FMA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 2-FMA develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 2-FMA presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of 2-FMA all stimulants will have a reduced effect.

Psychosis

Main article: Stimulant psychosis

The use of compounds within the amphetamine chemical class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions).[4][5] A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely.[5][6] The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.[5]

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legality

Handcuffs-300px.png

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

2-FMA is currently a gray area compound within all parts of the world, meaning its regulation lies in a legal gray area and that it is not known to be specifically illegal ("scheduled") within any country. However, people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

  • Canada: 2-FMA would be considered Schedule I as it is an analogue of Amphetamine.[8]
  • China - As of October 2015 2-FMA is a controlled substance in China.[9]
  • Germany: On December 13, 2014, 2-FMA was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[10]
  • New Zealand: 2-FMA is an amphetamine analogue, so is a Schedule 3 controlled substance in New Zealand.[11]
  • United Kingdom: 2-FMA is considered a Class A drug as a result of the amphetamine analogue clause of the Misuse of Drugs Act 1971.[12]

See also

External links

References

  1. http://drugs.tripsit.me/2-fma Tripsit Factsheets - 2FMA
  2. Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs). (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/15639609
  3. Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20074881
  4. http://www.drugabuse.gov/drugs-abuse/emerging-trends
  5. 5.0 5.1 5.2 Shoptaw, S. J., Kao, U., & Ling, W. (2009). Treatment for amphetamine psychosis. The Cochrane Library.
  6. Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.
  7. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  8. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
  9. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  10. Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm
  11. http://www.legislation.govt.nz/act/public/1975/0116/latest/whole.html#DLM436576
  12. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I