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Summary sheet: 2C-T
Chemical Nomenclature
Common names 2C-T, Tesseract
Substitutive name 4-Fluoromethylthio-2,5-dimethoxyphenethylamine
Systematic name 4-(2-Fluoromethylthio)-2,5-dimethoxyphenethylamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 20 mg
Light 40 - 60 mg
Common 60 - 100 mg
Strong 100 - 120 mg
Heavy 125 mg +
Total 3 - 6 hours
Onset 30 - 45 minutes
Peak 30 - 115 minutes
Offset 1 - 2 hours
After effects 1 - 2 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2,5-Dimethoxy-4-methylthiophenethylamine (commonly known as 2C-T) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.

2C-T It was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin[1] It is described in Shulgin's 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[2]

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has a relatively short history of human usage. It is highly advised to approach this hallucinogenic substance with the proper amount of precaution and harm reduction practices if using it.

History and culture

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This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.

2C-T is almost unknown on the black market and is rarely sold online.


Generic structure of a phenethylamine molecule

2C-T, or 2,5-dimethoxy-4-methylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through a methyl chain. 2C-T belongs to the 2C family of phenethylamines which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T is also substituted at R4 with an methyl thioether group.


Further information: Serotonergic psychedelic

The mechanism of action that produces 2C-T’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Being similar in structure to 2C-T-2 and 2C-T-7, this compound may have some MAOI properties.

Subjective effects

The effects of 2C-T have been described as being less visual and more in the body. Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Visual effects

Cognitive effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational 2C-T use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.

Anecdotal reports suggest that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this substance.

Dependence and abuse potential

2C-T is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

Although only speculative, it is worth noting that if 2C-T does have MAOI effects this could indicate that 2C-T is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[3] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Legal status

  • Canada: 2C-T would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[4]
  • United Kingdom: 2C-T is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[5]
  • United States: 2C-T is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.[citation needed]

See also

External links



  1. Nichols DE, Shulgin AT (October 1976). "Sulfur analogs of psychotomimetic amines". J Pharm Sci. 65 (10): 1554–6. CiteSeerX doi:10.1002/jps.2600651040. PMID 978423.
  2. Shulgin, A., & Shulgin, A. (1991).
  3. Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling |
  4. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |
  5. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from