MDPV

From PsychonautWiki
(Redirected from Methylenedioxypyrovalerone)
Jump to: navigation, search

Skull and crossbones darktextred2.png

MDPV may cause psychosis, mania and addiction at a significantly higher rate than other stimulants.

Due to its unusually long duration, extreme potency, and compulsive nature, it is strongly discouraged to abuse this substance in high doses, multiple days in a row, or in combination with other drugs known to increase the risk of psychosis. Please see this section for more details.

Summary sheet: MDPV
MDPV
Molecular structure of MDPV
MDPV.svg
Chemical Nomenclature
Common names MDPV, "Bath Salts", NRG-1
Substitutive name 3,4-Methylenedioxypyrovalerone
Systematic name 1-(1,3-Benzodioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one
Class Membership
Psychoactive class Stimulant, Entactogen
Chemical class Cathinone / Pyrrolidine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 2 - 4 mg
Light 4 - 8 mg
Common 8 - 14 mg
Strong 14 - 25 mg
Heavy 25 mg +
Duration
Total 2 - 7 hours
Onset 15 - 30 minutes
Peak 1 - 4 hours
Offset 0.5 - 2 hours
After effects 2 - 48 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

3,4-Methylenedioxypyrovalerone (also known as MDPV, NRG-1, and imprecisely as Bath Salts, among many others) is a novel, extremely potent synthetic stimulant substance of the cathinone and pyrrolidine chemical classes that produces states of extreme stimulant euphoria, disinhibition, and sexual arousal when administered. MDPV is thought to act primarily as as a norepinephrine-dopamine reuptake inhibitor (NDRI) and possesses powerful euphoric stimulant qualities. It was first developed in the 1960s by a team at Boehringer Ingelheim.[1]

MDPV remained an obscure stimulant until around 2004, when it was reportedly first made available to the public as a designer drug. Products labeled as "bath salts" containing MDPV were previously sold as recreational drugs in gas stations and convenience stores in the United States, similar to the marketing strategy of Spice and K2 as incense.[citation needed]

Historical reports show records of the preparation of MDPV for potential use as a CNS stimulant. It was claimed to have potential to be an alternative for racemic amphetamine and, although showing some desirable qualities such as reduced toxicity as compared to amphetamine, MDPV was chosen to not be developed as a medicinal drug.[2]

Several incidents of psychological and physical harm have been attributed to the use of MDPV, including an unusually large number of fatalities. A total of 107 non-fatal intoxications and 99 analytically confirmed deaths related to MDPV between September 2009 and August 2013 were reported by nine European countries.[3]

Chemistry

MDPV, or 3,4-Methylenedioxypyrovalerone, is a synthetic stimulant of the cathinone and pyrrolidine classes. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound a-PVP, developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence.[4] However, despite some shared structural features, the effects of MDPV bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily classical stimulant effects with only mild entactogenic qualities.[5]

Pharmacology

MDPV is thought to act primarily as a potent norepinephrine-dopamine reuptake inhibitor. Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this inhibition is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. Serotonin also plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that MDPV produces. Mainly possessing re-uptake inhibiting qualities, MDPV could be considered more like cocaine or methylphenidate than amphetamine in method of action.[6] In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
Child.svg

After effects
Aftereffects (3).svg

Cognitive effects
User.svg


Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

Ambulance2.png

This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

MDPV has a relatively short history of human use, with very few mentions concerning the use thereof before 2004. Although once considered a potential alternative to existing stimulants with a lower risk for toxicity, human MDPV administration has not been extensively studied in a clinical setting for many decades. Despite this, several recent studies on cases of persisting psychosis caused by chronic use of MDPV show promising rates of recovery among individuals who are treated with certain antipsychotics and first-line antihistamines.[10] There is currently no conclusive data concerning the neurotoxicity of MDPV in the human brain.[citation needed]

Anecdotal evidence from those who have tried MDPV in the community suggest that there are no negative health effects associated with the substance if simply taken at low doses by itself and when used sparingly (but nothing can be completely guaranteed).

Data taken from in-vitro and in-vivo studies have indicated that MDPV shares similar properties to methamphetamine and cocaine; in fact, MDPV is more potent than these two stimulants in a number of varying ways.[11] The over-excitation of dopamine and noradrenaline caused by MDPV use, combined with MDPV's potential inability to create compensatory serotonergic activity, sets the stage for a number of hostile and psychotic reactions to the drug. These hostile tendencies have been witnessed in emergency response situations, and have also seen wide television coverage in the past, after an individual under the influence of MDPV viciously assaulted an innocent bystander. It is uncertain if the individual had any pre-existing mental disorders or if he was under the influence of any other drugs.Template:Citation neeeded

Lethal dosage

The exact lethal dosage of MDPV is unknown and no formal studies have been carried out in humans. For sake of reference, one report placed the lethal dosage for a 39 year old male at 0.4 micrograms per millilitre or greater following the results of a post mortem,[12] but this data is far too individually unique and the variables simply too diverse to derive any kind of meaningful information from it. MDPV may be quantified in blood, plasma or urine by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Blood or plasma MDPV concentrations are expected to be in a range of 10–50 μg/L in persons using the drug recreationally, >50 μg/L in intoxicated patients, and >300 μg/L in victims of acute overdose.[13]

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

More so than other stimulants, the chronic use of MDPV can be considered moderately to highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a serious risk among users of MDPV as it easily causes compulsive redosing and causes highly unpleasant comedown symptoms.

Psychosis

Main article: Stimulant psychosis

User reports indicate that chronic abuse or single exposure overdose of MDPV can potentially lead to psychosis more readily than the vast majority of stimulants. Psychotic symptoms from MDPV can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal status

  • Australia - In Western Australia, MDPV has been banned under the Poisons Act 1964, having been included in Appendix A Schedule 9 of the Poisons Act 1964 as from February 11, 2012. The Director of Public Prosecutions for Western Australia announced that anyone intending to sell or supply MDPV faces a maximum $100,000 fine or 25 years in jail. Users face a $2000 fine or two years' jail. Therefore, anyone caught with MDPV can be charged with possession, selling, supplying or intent to sell or supply.[15]
  • Austria: Since January 1, 2012, MDPV is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich)
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[16]
  • Canada - On June 5, 2012 the Canadian Health Minister Leona Aglukkaq announced that MDPV would be listed on Schedule I of the Controlled Drugs and Substances Act, which was passed into law on September 26, 2012.[17]
  • Finland - MDPV is specifically listed as a controlled substance in Finland (listed appendix IV substance as of June 28, 2010),[18] Denmark]] and Sweden. In Sweden a 33-year-old man has been sentenced to six years in prison by an appellate court, Hovrätt, for possession of 250 grams of MDPV that had been acquired prior to criminalization.[19]
  • United Kingdom - MDPV is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.[20]
  • United States - On October 21, 2011, MDPV became a DEA federally scheduled drug. The DEA issued a temporary one-year ban on MDPV, classifying it as a schedule I substance. On December 8, 2011, under the Synthetic Drug Control Act, the US House of Representatives voted to ban MDPV and a variety of other synthetic drugs which had been sold legally in stores.[21]

See also

External links

References

  1. US Patent 3478050 - 1-(3',4'-methylenedioxy-phenyl)-2-pyrrolidino-alkanones-(1) | https://www.google.com/patents/US3478050
  2. MDPV Summary | http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1
  3. EMCDDA–Europol Joint Report on a new psychoactive substance: MDPV (3,4-methylenedioxypyrovalerone) | http://www.emcdda.europa.eu/system/files/publications/819/TDAS14001ENN_466653.pdf
  4. US Patent 3478050 - 1-(3',4'-methylenedioxy-phenyl)-2-pyrrolidino-alkanones-(1) | https://www.google.com/patents/US3478050
  5. MDPV | https://wiki.tripsit.me/wiki/MDPV
  6. http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1
  7. InnerExplorer. "Personal Research Comedown Guide: An Experience with MDPV (ID 98601)". Erowid.org. Feb 21, 2013. erowid.org/exp/98601 | https://erowid.org/experiences/exp.php?ID=98601
  8. Trippy. "Seemingly Real Paranoid Hallucination Hell: An Experience with MDPV (ID 91741)". Erowid.org. Jun 30, 2011. erowid.org/exp/91741 | https://erowid.org/experiences/exp.php?ID=91741
  9. Some Guy. "Psychosis: An Experience with MDPV (ID 78382)". Erowid.org. Mar 22, 2010. erowid.org/exp/78382 | https://www.erowid.org/experiences/exp.php?ID=78382
  10. Studies concerning MDPV hospitalization, pages 19 to 25. | http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1
  11. MDPV In-vivo statistics | http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1
  12. http://jat.oxfordjournals.org/content/37/3/182.full
  13. Disposition of toxic drugs and chemicals in man | isbn = 978-0-9626523-9-4
  14. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  15. Emerging drug, MDPV banned in WA | https://www.mediastatements.wa.gov.au/Pages/Barnett/2012/02/Emerging-drug,-MDPV-banned-in-WA.aspx
  16. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  17. 'Bath salts' drug ingredient banned in Canada | http://www.cbc.ca/news/politics/bath-salts-drug-ingredient-banned-in-canada-1.1174926
  18. Finlex: huumausaineina pidettävistä aineista, valmisteista ja kasveista annetun valtioneuvoston asetuksen liitteen IV muuttamisesta | http://www.finlex.fi/fi/laki/alkup/2010/20100596
  19. Hovrätten skärper straff i MDPV-dom | http://www.nt.se/nyheter/?articleid=6057819
  20. United Kingdom. (2010). Misuse of Drugs Act 1971 (S.I. 2010/1207). London: The Stationery Office Limited. Retrieved February 9, 2018, from https://www.legislation.gov.uk/uksi/2010/1207/made
  21. House Votes to Ban 'Spice,' 'Bath Salts' ABC News | http://abcnews.go.com/Blotter/house-votes-ban-fake-marijuana-fake-cocaine/story?id=15116235