DPT

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Summary sheet: DPT
DPT
DPT.svg
Chemical Nomenclature
Common names DPT, Dipropyltryptamine, "The Light"
Substitutive name N,N-Dipropyltryptamine
Systematic name 3-[2-(Dipropylamino)ethyl]indole
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation.
This dosage and duration information has been sourced from TripSit
Threshold 10 - 15 mg
Light 15 - 20 mg
Common 20 - 50 mg
Strong 50 - 100 mg
Heavy 100 mg +
Duration
Total 30 - 90 minutes
Onset 0 - 1 minutes
After effects 2 - 4 hours
Oral
Dosage
Threshold 50 - 75 mg
Light 75 - 150 mg
Common 150 - 250 mg
Strong 250 - 350 mg
Heavy 350 mg +
Duration
Total 2 - 4 hours
Onset 20 - 60 minutes
After effects 2 - 3 hours



Insufflated
Dosage
Threshold 5 - 20 mg
Light 20 - 50 mg
Common 50 - 100 mg
Strong 100 - 200 mg
Heavy 200 mg +
Duration
Total 3 - 5 hours
Onset 5 - 20 minutes
Peak 30 - 46 minutes
After effects 2 - 4 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

N,N-Dipropyltryptamine (also known as Dipropyltryptamine, DPT, and "The Light") is a synthetic psychedelic of the tryptamine chemical class that produces powerful, short-lived visionary psychedelic effects similar to, but often considered to be more unpredictable and "challenging," than those of DMT when administered. It is a structural homolog of DMT that is often reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and a tendency to feel more "bizarre" and "chaotic", if not "unsettling", relative to DMT and other psychedelic tryptamines.

DPT was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism.[1] It has also been researched in high doses to induce peak experiences for terminal cancer patients.[2] It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of psychedelics and refer to them as "the true flesh of God."[3]

DPT is commonly consumed via insufflation or orally. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered intramuscularly or via vaporization after conversion to the freebase form, and this appears to be the preferred route of administration in research settings. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light".[citation needed]

Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the research chemicals market as a legal, grey-market alternative to DMT, and commercially distributed through online vendors. Due to the powerful, mentally jarring and disturbing hallucinatory states it can produce, many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with hallucinogens. Therefore it is highly advised to approach this unusually powerful psychedelic substance with the proper amount of precaution and harm reduction practices if one chooses to use it.

History and culture

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Chemistry

DPT, or N,N-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. DPT contains two propyl groups carbon chains bound to the terminal amine RN of its tryptamine backbone.

DPT has a number of substituted analogs such as 4-HO-DPT or 4-AcO-DPT.

Pharmacology

Further information: Serotonergic psychedelic

DPT's psychedelic effects are believed to come from its efficacy at the 5-HT2A and 5-HT1A receptor as a partial agonist.[4]

The role of these interactions and how they result in the psychedelic experience continues to remain subject to ongoing scientific investigation.

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects
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Visual effects
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Multi-sensory effects
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Transpersonal effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the community who have tried DPT suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

DPT is not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is generally considered to have a built-in, self-regulating aspect to it, which can either manifest subconsciously or even directly via autonomous entity contact in some reported cases.

Tolerance to the effects of DPT have been shown to not be built in animal models.[5] However, it has been reported to be able to build slightly relative to DMT, although still to an insignificant degree compared to most psychedelics.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal status

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As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Latvia: DPT is a Schedule I drug.[7]
  • New Zealand: DPT is an analogue of DMT, so is a Class C controlled drug in New Zealand.[8]
  • Sweden - Following its sale as a designer drug, DPT was made illegal in Sweden on 26 January 2016.[9]
  • United Kingdom: DPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.[10]
  • United States: DPT is unscheduled in the United States. It may be considered an analogue of DET, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed] DPT is a Schedule I controlled substance in the states of Florida, Maine, and Oklahoma making it illegal to buy, sell, or possess.[11] [12]

See also

External links

Literature

  • Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355. https://doi.org/10.1124/pr.115.011478
  • Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. Journal of Psychedelic Drugs, 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020
  • Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. International Pharmacopsychiatry, 8(1), 104-115. PMID: 4150711
  • Nichols, D. E. (2004). Hallucinogens. Pharmacology & Therapeutics, 101(2), 131-181. https://doi.org/10.1016/j.pharmthera.2003.11.002

References

  1. Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. International Pharmacopsychiatry, 8(1), 104-115. PMID: 4150711
  2. Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. Journal of Psychedelic Drugs, 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020
  3. Temple of the True Inner Light | http://psychede.tripod.com/
  4. William E. Fantegrossi, Chad J. Reissig, Elyse B. Katz, Haley L. Yarosh, Kenner C. Rice, Jerrold C. Winterb. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008 January; 88(3): 358–365.
  5. Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice. | https://www.ncbi.nlm.nih.gov/pubmed/25271256
  6. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  7. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (Triptamīni) | http://likumi.lv/doc.php?id=121086
  8. http://www.legislation.govt.nz/act/public/1975/0116/latest/whole.html#DLM436576
  9. (in Swedish) Folkhälsomyndigheten. | https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2016/januari/31-nya-substanser-klassas-som-narkotika-eller-halsofarlig-vara/
  10. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
  11. http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html | Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL
  12. http://www.oscn.net/applications/oscn/DeliverDocument.asp?CiteID=98866