DPT

Summary sheet: DPT

DPT
Chemical Nomenclature
Common names	DPT, Dipropyltryptamine, The Light
Substitutive name	N,N-Dipropyltryptamine
Systematic name	3-[2-(Dipropylamino)ethyl]indole
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Smoked Dosage Threshold 10 mg Light 15 - 20 mg Common 20 - 50 mg Strong 50 - 100 mg Heavy 100 mg + Duration Total 30 - 90 minutes Onset 0 - 1 minutes After effects 2 - 4 hours ⇣ Oral Dosage Threshold 50 mg Light 75 - 150 mg Common 150 - 250 mg Strong 250 - 350 mg Heavy 350 mg + Duration Total 2 - 4 hours Onset 20 - 60 minutes After effects 2 - 3 hours ⇣ Insufflated Dosage Threshold 5 mg Light 20 - 50 mg Common 50 - 100 mg Strong 100 - 200 mg Heavy 200 mg + Duration Total 3 - 5 hours Onset 5 - 20 minutes Peak 30 - 45 minutes After effects 2 - 4 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

N,N-Dipropyltryptamine (also known as Dipropyltryptamine, DPT, and "The Light") is a lesser-known psychedelic substance of the tryptamine class. It is closely related to DMT and is reported to be uniquely similar in its hallucinogenic intensity, albeit with a moderately longer duration and greater unpredictability relative to DMT and other psychedelic tryptamines.

DPT was first synthesized in 1950. Human use was first reported in 1973, where it was researched in low doses as an adjunct to therapy for alcoholism. It has also been researched in high doses to induce peak experiences for terminal cancer patients. It has gained some notoriety for its adoption as the primary sacrament for the "Temple of the True Inner Light" in the United States, a Christian off-shoot organization who believe in the ritual use of psychedelics and refer to them as "the true flesh of God."

DPT is commonly consumed via insufflation or orally. Many report the experience of insufflation to be very congestive and painful which, with the rapidness of onset, does not give the user much time to acclimate themselves to its powerful effects. It can also be administered intramuscularly or via vaporization after conversion to the freebase form. Smoking the freebase is reported to be the preferred route used by the "Temple of True Inner Light". More experienced members ingest a DPT tea.

Very little data exists about the pharmacological properties, metabolism, and toxicity of DPT, and it has relatively little history of human usage. It has long been available on the research chemicals market as a legal, grey-market alternative to DMT, and commercially distributed through online vendors. Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with hallucinogens. It is highly advised to approach this powerful psychedelic substance with the proper amount of precaution and harm reduction practices when using it.

Chemistry

DPT, or N,N-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. DPT contains two propyl groups carbon chains bound to the terminal amine R_N of its tryptamine backbone.

DPT has a number of substituted analogs such as 4-HO-DPT or 4-AcO-DPT.

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

Further information: Serotonergic psychedelic

Studies on rodents have found that the effectiveness with which a selective 5-HT_2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT_2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT_1A receptor antagonist also imply a 5-HT_1A-mediated component to the actions of DPT. The role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

Subjective effects

Relative to psychedelic tryptamines like DMT, DPT is often reported to be similar in its hallucinogenic intensity, albeit with a moderately longer duration and more challenging effects. DPT experiences are often described as a "bizarre", "unsettling", and "darker" version of DMT experiences. DPT is reported to be more sensual and physical than DMT and other psychedelics with a corresponding amount of adverse physical effects.

At light to moderate doses, users often report a slight sense of anaesthetization and relaxation. As the dose increases, hyper-awareness of one's heart rate and breathing increases and body tremors and loss of muscle control are often reported. The effects of DPT can range from strong euphoria and sensuality to nausea, panic, and intense states dysphoria even within the same experience.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Spontaneous bodily sensations - The "body high" of DPT is generally more prominent to that of the better known DMT. There is often the sensation of limbs feeling disconnected from the body, a force pinning the body to the surface on which it lay and body tremors which can often make the user feel aware of but not in control of their body.
    • Physical euphoria
  • Physical autonomy
  • Changes in felt bodily form
  • Changes in felt gravity - At higher doses, physical feelings of moving through spaces at quick speeds or being completely pinned down are common.
  • Abnormal heartbeat
  • Increased blood pressure
  • Motor control loss
  • Muscle contractions
  • Nausea
  • Headaches
  • Dehydration
  • Excessive yawning
  • Pupil dilation
  • Increased libido - This effect appears to occur with more regularity and intensity than other psychedelic tryptamines.

Visual effects

• Enhancements

  • Visual acuity enhancement
  • Colour enhancement
  • Pattern recognition enhancement
  • Magnification

  Distortions

  • Drifting (melting, breathing, morphing and flowing)
  • After images
  • Colour replacement
  • Colour shifting
  • Environmental patterning
  • Recursion
  • Scenery slicing
  • Symmetrical texture repetition
  • Tracers
  • Visual haze

  Geometry

  DPT visual geometry can be described through its variations as intricate in complexity, both abstract and concrete in form, more digital than organic in feel, choppy and only loosely structured in organization, brightly lit, multicolored in scheme, sharp in its edges, fast in speed, simultaneously smooth and glitching in motion, immersive in depth, and consistent in intensity. At higher doses, it is more likely to result in states of level 8A geometry over level 8B.

  Hallucinatory states

  DPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic barring DMT and ibogaine. These effects include:

  • Transformations
  • Machinescapes - These are reported to be more common with DPT than with DMT, which lends to its common description as feeling more "industrial" and futuristic, while DMT visuals can often be described as "ancient" or "earthy" in feel.
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - As with DMT, DPT produces high level internal hallucinations at appropriate doses more consistently than most other psychedelics. They are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, non-autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental narrative in their overall theme, with a tendency towards chaotic disorganization and incoherence.
  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - These are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, non-autonomous in controllability, geometry-based in style and typically of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental narrative in their overall theme, with a tendency towards chaotic disorganization and incoherence.

Cognitive effects

• • Anxiety & Paranoia
  • Conceptual thinking
  • Cognitive euphoria & Cognitive dysphoria
  • Déjà vu
  • Emotionality enhancement
  • Feelings of impending doom
    • Catharsis
    • Rejuvenation
  • Increased music appreciation
  • Increased sense of humor
    • Laughter fits
  • Novelty enhancement
  • Immersion enhancement
  • Personal meaning enhancement
  • Memory suppression
    • Ego death
  • Confusion
  • Language suppression
  • Personal bias suppression
  • Simultaneous emotions
  • Spatial disorientation
  • Autonomous voice communication
  • Multiple thought streams
  • Thought disorganization
  • Thought loops
  • Time distortion
  • Wakefulness

Multi-sensory effects

• • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Transpersonal effects

• Many reports indicate that while DPT possesses the raw hallucinogenic power to induce transpersonal states traditionally associated with "classical psychedelics", it does so in a significantly less consistent fashion due to the utter bizarreness and oft-noted "sinister", chaotic, or "forceful" undertones that can be present throughout the experience. What insights it can lead the user to typically occur during the aftermath and integration phase that follows, which shares some qualities of a typical near-death experience.
  • Spirituality enhancement
  • Existential self-realization
  • Perception of predeterminism
  • Perception of eternalism
  • Perceived exposure to inner mechanics of consciousness
  • Unity and interconnectedness

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

• Experience: Oral & Insufflated DPT, Running up the Doses
• Experience:10mg & 20mg Intravenous DPT HCl - Familiar Shapes, Experiencing Death, Immersed in The Light
• Experience:150mg DPT - A Walk Into The Depths of Insanity
• Experience:75 mg - Good tunes feat. Jeb Bush

Additional experience reports can be found here:

• Erowid Experience Vaults: DPT

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DPT is a research chemical with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.

Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it sparingly (although nothing can be guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

DPT is not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is reported to be self-limiting.

Tolerance to the effects of DPT has been shown to not be built in animal models. However, it has been reported to be able to build slightly relative to DMT, although still to an insignificant degree compared to most psychedelics.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Tramadol - Tramadol lowers the seizure threshold and LSD also has the potential to induce seizures in susceptible individuals. and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.
• Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.
• Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.

Legal status

• Germany: DPT is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
• Latvia: DPT is a Schedule I controlled substance.
• New Zealand: DPT is an analogue of DMT, therefore it is a Class C controlled substance in New Zealand.
• Sweden: Following its sale as a designer drug, DPT was made illegal in Sweden on January 26, 2016.
• Switzerland: DPT is a controlled substance specifically named under Verzeichnis E.
• United Kingdom: DPT is a Class A controlled substance in the United Kingdom as a result of the tryptamine catch-all clause.
• United States: DPT is unscheduled in most of the United States. However, some states prohibited DPT, making it illegal to buy, sell, or possess:
  • Florida: DPT is a Schedule I controlled substance.
  • Maine: DPT is a Schedule X controlled substance.
  • Oklahoma: DPT is a Schedule I controlled substance.

See also

• Responsible use
• Research chemical
• Psychedelics
• Tryptamines
• DMT
• DET

External links

• DPT (Wikipedia)
• DPT (Erowid Vault)
• DPT (TiHKAL / Isomer Design)

Literature

• Soskin, R.A., Grof, S., & Richards, W.A. (1973). Low doses of Dipropyltryptamine in psychotherapy. Archives of General Psychiatry, 28 6, 817-21.
• Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. Journal of Psychedelic Drugs, 9(1), 1-10. http://dx.doi.org/10.1080/02791072.1977.10472020
• Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1972). DPT as an adjunct in psychotherapy of alcoholics. International Pharmacopsychiatry, 8(1), 104-115. PMID: 4150711
• Li, J., Rice, K.C., & France, C.P. (2007). Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. Behavioural Pharmacology, 18 4, 283-8.