Talk:2C-EF

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Summary sheet: 2C-EF
2C-EF
2C-EF.svg
Chemical Nomenclature
Common names 2C-EF
Substitutive name 4-Fluoroethyl-2,5-dimethoxyphenethylamine
Systematic name 2-[4-(2-Fluoroethyl)-2,5-dimethoxyphenyl]ethan-1-amine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 1 mg
Light 3 - 6 mg
Common 6 - 12 mg
Strong 12 - ? mg
Heavy ? mg +
Duration
Total 8 - 12 hours
Onset 15 - 60 minutes
Come up 2 - 3 hours
Peak 2 - 3 hours
Offset 2.5 - 3.5 hours
After effects ? hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Cannabis
Stimulants
Tramadol
Lithium


2,5-dimethoxy-4-(2-fluoroethyl)phenethylamine (also known as 2C-EF) is a lesser-known psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Like other psychedelics, it is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is poorly understood.

2C-EF was first mentionned by Alexander Shulgin in his book PiHKAL ("Phenethylamines I Have Known and Loved")[1] and later reverenced with a dosage range of 6 to 12mg and a duration of 12h. [2]

Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, and euphoria. User reports characterize 2C-EF like 2C-E as a highly unpredictable, dose-sensitive psychedelic that is capable of producing strong visual distortions along with a significant "body load", which includes nausea and bodily discomfort.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-EF, and it has a limited history of human use. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with hallucinogens. It is highly advised to use harm reduction practices if using this substance.

History and culture

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2C-EF was first imagined by Alexander Shulgin,[1] who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[1] As he states in the #63 DOEF chapter, ```It would be every bit as much a treasure and ally as is 2C-B or 2C-I. In fact, I am sure enough about this prediction that I am willing to name the stuff 2C-EF.```

Chemistry

2C-EF or 2,5-dimethoxy-4-(2-fluoroethyl)phenethylamine is a phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-EF contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring with an hydrogen replace by fluorine on the last carbon of the ethyl group. 2C-EF belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.[1]

Pharmacology

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This pharmacology section is incomplete.

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Further information: Serotonergic psychedelic

2C-EF's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.


Physical effects
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    • Stimulation - 2C-EF is usually considered to be very energetic and stimulating in a fashion that is comparable to that of MDMA, although it is 'encouraged' instead of 'forced' according to many users.
    • Spontaneous bodily sensations - The "body high" of 2C-EF is reported to be similar to 2C-E and is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over the surface of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in intermittent waves. This skin tingling is much more pronounced than with other psychedelics. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
      • Physical euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
    • Tactile enhancement
    • Bodily control enhancement
    • Temperature regulation suppression
    • Muscle contractions
    • Increased heart rate[citation needed]
    • Increased blood pressure[citation needed]
    • Increased perspiration
    • Nausea - Less nausea is reported compared to 2C-E, but it still induces more nausea than other 2C-x compounds.
    • Dehydration
    • Frequent urination
    • Pupil dilation
    • Teeth grinding - This component can be considered to be less intense when compared with that of entactogenic stimulants like MDMA.
    • Seizure - This is a rarely observed effect but is believed to be a risk in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.[citation needed]

Visual effects
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  • Enhancements

    Distortions

    Geometry

    The visual geometry that is produced by this substance can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A. Compared to 2C-E is has been reported as more colourful especially in close eye scenarios.

    Hallucinatory states

    2C-EF produces a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This particularly holds true in comparison to other substances within the family of psychedelic phenethylamines. These effects include:

Cognitive effects
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Auditory effects
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Multi-sensory effects
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    • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states. However, many reports indicate that this substance is relatively reliable at inducing synaesthetic states.{citation needed

Transpersonal effects
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Combination effects

  • Cannabis - When used in combination with cannabis, both the visual and cognitive effects of 2C-EF can be intensified and extended with extreme efficiency. This should be used with extreme caution if one is not experienced with psychedelics as this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of 2C-EF have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis. {citation needed}
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 2C-EF are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. Additionally, users should be aware that there are reasons to believe that this combination may result in unforeseen neurotoxic effects, so a strong sense of caution and independent research are highly advised if one decides to experiment with this combination.[citation needed]
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, typically considered to be safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically distressing manner.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an 2C-EF trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between these substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-EF use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-EF is a research chemical with a limited history of human usage.

Anecdotal reports suggest that there are no negative health effects attributed to simply trying this substance by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance so as to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

Although no formal studies have been conducted, it is not unreasonable to assume that like psychedelics in general, 2C-EF is not habit-forming and that the desire to use it can actually decrease with use.

Tolerance to the effects of 2C-EF is built almost immediately after ingestion. After that, it takes about 1-2 days for the tolerance to be reduced to half and 2-4 days to be back at baseline (in the absence of further consumption). 2C-EF presents cross-tolerance with all psychedelics but not evenly, meaning that after the consumption of 2C-EF, some psychedelics will have significant reduced effects while some others will only be slightly affected.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

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As such, it may contain incomplete or wrong information. You can help by expanding it.

Due to the very recent apparition of 2C-EF on the market, it is not mentioned in the 1971 convention on psychotropic substances[4] and is probably unscheduled in most countries. It might fall under phenetylamines or 2C-X blanket bans in some jurisdictions. It might also be considered an analog of 2C-E due to structural similarities.

  • France: As of december 2024, 2C-EF is not explicitly scheduled. It is thus legal to possess, although in a grey area.[5]

See also

External links

Discussion

References

  1. ↑ 1.0 1.1 1.2 1.3 Alexander Shulgin; Ann Shulgin (1991). "#63. DOEF". PiHKAL: A Chemical Love Story. United States: Transform Press. ISBN 0963009605. OCLC 1166889264. 
  2. ↑ Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039. 
  3. ↑ Convention of 1971 on psychotropic substances (PDF) 
  4. ↑ Arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants 


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