Category:Panels

4-PO-5-MeO-DMT and 4-PO-5-HO-DMT may be neurotoxic

Compared to related indoles and tryptamines lacking substitutions at the 5,6-position, these new molecules might possess neurotoxic or convulsive properties due to their structure, suggesting potentially shared negative effects.

Alcohol may be dangerous to combine with modified-release dosage medications.

This dose dumping effect is an unintended rapid release of large amounts of a given drug, when administered through a modified-release dosage while co-ingesting ethanol.^[3] This is considered a pharmaceutical disadvantage due to the high risk of causing drug-induced toxicity by increasing the absorption and serum concentration above the therapeutic window of the drug. The best way to prevent this interaction is by avoiding the co-ingestion of both substances or using specific controlled-release formulations that are resistant to AIDD.

2C-P is very difficult to dose properly.

Due to its unusually slow onset, long duration, and steep dose-response curve, it is strongly discouraged to re-dose 2C-P earlier than every 3 hours to a total of 2 milligrams above a previously evaluated dose. Also, even for experienced trippers, it is advised to not go above a common dose for the first time (see dosage table) per 70 kg body weight, as the session will last for several times longer compared to most psychedelics. Please see this section for more details.

The toxicity and risks of 3-HO-PCE are as of this time totally unknown and there is evidence to suggest that it may be significantly more dangerous to use than any previous member of the arylcyclohexylamine class.

It should be noted that this substance has been speculated to come with the unique risk of fatal respiratory overdose due to its combination of potent opioid and dissociative effects. Until more is learned about this substance, users are advised to approach this substance with extreme caution, if not avoid it entirely, due to the unpredictable dangers that may come with its use.

3-MeO-PCE may have a higher risk of causing mania, delusions, and psychosis than other dissociatives.

It is strongly discouraged to take this substance in high dosages, for multiple days in a row, or in combination with other substances known to increase the risk of psychosis. Please see this section for more details.

3-MeO-PCP may be more likely to cause mania, delusions, and psychosis than other dissociatives.^[7][8][9]

It is strongly discouraged to take this substance in high dosages, for multiple days in a row, or in combination with other substances that increase the risk of psychosis. Please see this section for more details.

Belladonna is known to cause dangerous and extremely unpleasant experiences.

Please use responsible use practices when trying this drug and always have a trip sitter.

Do not perform this procedure indoors.

Due to the explosive nature of the solvents involved, attempting this procedure in underventilated areas (e.g. such as a small apartment room or basement) can result in serious injury, death or the destruction of property.

Black tar heroin is dangerous to inject

It's not practical to make black tar heroin sterile, for example, by heating a solution with a lighter for a minute. Black tar heroin injection is associated with Clostridium botulinum infection. Prion: "For prion elimination, various recommendations state 121–132 °C (250–270 °F) for 60 minutes or 134 °C (273 °F) for at least 18 minutes."^[11] A pressure cooker reach 120 °C at full pressure. However, we don't recommend black tar heroin injection even if you own a pressure cooker with a PSI meter due to lack of safety data.

Some bufo secretions are toxic

The toxic substances found in toads can be divided by chemical structure in two groups:

1. bufadienolides, which are cardiac glycosides (e.g., bufotalin, bufogenin)
2. tryptamine-related substances (e.g., bufotenin)

Ingestion of digoxin-like cardiac glycosides can be fatal. Ingestion of Bufo toad poison and eggs by humans has resulted in several reported cases of poisoning,^[12][13][14] some of which resulted in death. A court case in Spain, involving a physician who dosed people with smoked Mexican Toad poison, one of his customers died after inhaling three doses, instead of the usual of only one, had images of intoxicated with this smoke suffering obvious hypocalcemic hand muscular spasms.^[14][15][16]

Levamisole, a common cocaine adulterant, is linked to cocaine/levamisole-associated syndromes

By 2017, 87% of cocaine seized and analyzed in the US contained levamisole.^[20]

Cocaine- and levamisole-induced vasculitis (CLIV),^[21] is often used as an umbrella term for the vasculitic and necrotic complications seen with levamisole-adulterated cocaine, including both levamisole induced necrosis syndrome (LINES),^[22] and cocaine/levamisole-associated autoimmune syndrome (CLAAS).^[23]

To stay safer: DanceSafe recommends testing cocaine samples using a specific sequence of reagent testing kits (Morris > Marquis > Liebermann) for more reliable identification and adulterant detection. For detailed instructions, see their official testing guide (PDF), page 4.

Desoxypipradrol may lead to states of psychosis, mania and addiction at a significantly higher rate than other stimulants.

Due to its unusually long half-life and extreme potency, it is strongly discouraged to abuse this substance in high doses, multiple days in a row, or in combination with other substances known to increase the risk of psychosis. Please see this section for more details.

Ephylone has been linked to numerous overdoses and deaths.

It is strongly discouraged to use this substance in high doses, multiple times in a row, or in combination with other substances known to increase the risk of psychosis or serotonin syndrome. Please see this section for more details.

Hyoscyamus niger is known to cause dangerous and extremely unpleasant experiences.

Please use responsible use practices when trying this drug and always have a trip sitter.

Ibogaine can cause life-threatening heart complications.^[24]

It is strongly discouraged to use this substance in high doses or for multiple days in a row. Additionally, a trip sitter with proper medical training and equipment must be present. Please see this section for more details.

It is important to convert ibotenic acid to muscimol before consumption.

Please read Fly agaric: Ibotenic acid decarboxylation to muscimol to learn how to convert the relatively neurotoxic compound (speculated to be a stimulant^[25][26]) ibotenic acid to muscimol.

Also, novel edibles "Amanita Mushroom Gummies" contain a substantial amount of ibotenic acid along with muscimol and muscarine. Given the toxicity of ibotenic acid, the consumption of those preparations even in small doses should be avoided!^[27]

A 1998 publication listed Muscimol as an Extremely Hazardous Substance (EHS) on the Environmental Protection Agency's (EPA) list. However, a later document from 2006 shows it was removed from the list.

Always check if your MAOIs also inhibit other substances. Most MAOIs are also cytochrome P450 inhibitors and some are also acetylcholinesterase inhibitors (AChEIs)

Substances that inhibits the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.

Mandrakes are very poisonous and known to cause dangerous and extremely unpleasant experiences.

Please use responsible use practices when trying this drug and always have a trip sitter.

Do not trust underground brand names, they are easily falsified

The previously good reputation of 'Mistubishi's' amongst ecstasy-users has been dealt a blow with the discovery of deadly batches (PMA has been found in White Mitsubishi,^[28] PMMA has been found in Red Mitsubishi^[29])

MDPV may cause psychosis, mania and addiction at a significantly higher rate than other stimulants.

Due to its unusually long duration, extreme potency, and compulsive nature, it is strongly discouraged to abuse this substance in high doses, multiple days in a row, or in combination with other drugs known to increase the risk of psychosis. MDPV is one of several designer drugs that has been sold as "bath salt" both in the US and in Europe; In a four-year period between September 2009 and August 2013, the European Union (EU) reported a concerningly high number of MDPV-related deaths, reaching 99.^[30]

Please see this section for more details.

Hunting psychoactive mushrooms in nature can be very dangerous.

Caution is advised because poisonous or deadly mushrooms can easily be mistaken for edible ones.

Commercial seeds are often treated with fungicides

It is important to note that each seed is treated with fungicides and other toxic substances, which can further exacerbate the toxicity levels.^[31]

Nitrous oxide can cause irreversible neurotoxic damages

Frequent and/or chronic use can cause vitamin B₁₂ depletion, such as other rapidly vitamin B₁₂ depleting substance, may lead to severe nerve damage.^[35] We recommend that you always supplement with vitamin B12 if you use this substance, regardless dose and frequency to be on the safe side. Especially those with "decreased vitamin B12 absorption, such as in those with small bowel resection, irritable bowel disease, and/or pernicious anemia, and those with reduced intake, such as in vegans and vegetarians".^[36] Additionally, improper use puts the user at risk of oxygen deprivation. It is highly advised to use harm reduction practices if using this substance.

PCE may cause psychosis and mania at a significantly higher rate than other dissociatives.^[37][38]

It is strongly discouraged to use this substance in high doses or multiple days in a row. Please see this section for more details.

PCP may cause psychosis and mania at a significantly higher rate than other dissociatives.^[39][40]

It is strongly discouraged to use this substance in high doses or multiple days in a row. Please see this section for more details.

PMA can cause life-threatening side effects (such as hyperthermia and serotonin syndrome) even at moderate doses.

As a result, using this substance is strongly discouraged. It is also advised to always test your MDMA for the presence of PMA using a reagent testing kit as it is a common adulterant. Please see this section for more details.

PMMA can cause serious side effects even at moderate doses, such as hyperthermia and serotonin syndrome, which can easily result in death or hospitalization.

As a result, it is strongly discouraged to use this substance. Please see this section for more details.

Synthetic Cannabinoids: Over 1,000 hospitalized, 94 deaths linked to three types

Multiple synthetic cannabinoids pose serious health risks. MDMB-FUBINACA alone is linked to over 1,000 hospitalizations and 40 deaths, primarily in Russia and Belarus. Across Europe, MDMB-CHMICA and 5F-ADB have caused a combined 54 deaths between 2014 and 2017.

Refeeding syndrome if severe enough, may result in death

Refeeding syndrome (RFS) is a metabolic disturbance which occurs as a result of reinstitution of nutrition in people and animals who are starved, severely malnourished, or metabolically stressed because of severe illness. When too much food or liquid nutrition supplement is eaten during the initial four to seven days following a malnutrition event, the production of glycogen, fat and protein in cells may cause low serum concentrations of potassium (hypokalemia), magnesium (magnesium deficiency) and phosphate (hypophosphatemia).^[46][47] The electrolyte imbalance may cause neurologic, pulmonary, cardiac, neuromuscular, and hematologic symptoms—many of which, if severe enough, may result in death.

Refeeding syndrome can occur when someone does not eat for several days at a time usually beginning after 4–5 days with no food.^[48]

Stimulants like amphetamines, methylphenidate, and cocaine, along with opiates, contribute to appetite suppression. This can lead to prolonged periods of inadequate calorie intake, mimicking anorexia nervosa. Individuals with drug abuse who begin to reintroduce normal eating habits after a period of malnutrition may be at increased risk for refeeding syndrome.^[49]