|Summary sheet: Mirtazapine|
|Common names||Avanza, Axit, Mirtaz, Mirtazon, Remeron, Zispin|
|Psychoactive class||Deliriant / Depressant|
|Routes of Administration|
Mirtazapine (trade name Remeron, among others) is an antidepressant substance of the piperazinoazepine class. At high doses, it has been reported to act as an atypical psychedelic and sedative. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
Mirtazapine was developed in the Netherlands and introduced in the United States in 1996. Its patent expired in 2004 and generic versions have been widely available since. It is used primarily in the treatment of major depressive disorder and other mood disorders. It has also been prescribed off-label for the treatment of generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, low appetite, insomnia, nausea/vomiting, itching, and headaches and migraines.
Higher doses of mirtazapine (that exceed the recommended prescription dose) are reported to produce an unusual mixture of psychedelic and sedative effects. Subjective effects include sedation and mild-moderate versions of open and closed-eye visuals, conceptual thinking, and euphoria. Mirtazapines has potential paradoxical effects concerning it's sedative effects. Anecdotal reports and studies suggest it's Sedation decreases as the dose increases. (7.5mg is more sedating than 15mg.) One theory suggests it has minor Stimulant effects that overpowers it's sedative effects.
The toxicity and health risks of recreational mirtazapine use is not known. It is highly advised to use harm reduction practices if using this substance.
Mirtazapine is a synthetic tetrahedral molecule of the piperazino-azepine and phenethylamine group of compounds. It is comprised of a fusion of pyridine, benzene, azepine, and piperazine rings. It is a tetracyclic antidepressant, named so because of their four-ring structure. Mirtazapine is the 6-aza analog of mianserin, which is pharmacologically similar in function.
Mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.
- 5-HT2A receptor
- 5-HT2B receptor
- 5-HT2C receptor
- 5-HT3 receptor
- 5-HT7 receptor
- α1-adrenergic receptor
- α2A-adrenergic receptor
- α2B-adrenergic receptor
- α2C-adrenergic receptor
- H1 receptor
- mACH receptors
Additionally, Mirtazapine has also been observed to indirectly agonize the following GCPR in humans:
Mirtazapine has also been found to modulate the κ3 opioid receptor, supporting the claim that mirtazapine causes pain relief and adds to the sedative and hallucinogenic effects of mirtazapine. This even may explain mirtazapine's withdrawal/discontinuation effects as well as its promotion of diuresis and a possible increase in food intake (usually resulting in weight gain).
It should be noted that although some of these effects are observed in those who take mirtazapine recreationally (or one off dosing) most neurophysiological effects are observed in those with on-going use (15, 30 and 45 mg daily prescribed for depression, etc) due to a maintained level of mirtazapine in the body.
The oral bioavailability of mirtazapine is about 50%. It is found mostly bound to plasma proteins, about 85%. It is metabolized primarily in the liver by demethylation and hydroxylation via cytochrome P450 enzymes, CYP1A2, CYP2D6, CYP3A4. One of its major metabolites is desmethylmirtazapine. The overall elimination half-life is 20–40 hours. It is conjugated in the kidney for excretion in the urine, where 75% of the drug is excreted, and about 15% is eliminated in feces.
Although mirtazapine exhibits almost exclusively psychedelic effects, the hallucinations that accompany it do have distinctively deliriant-like effects. For example, they are often delirious in their believability and rarely comprised of condensed visual geometry. Instead they tend to be solid and extremely realistic in appearance.
The mental processes, thought patterns and general head space experienced during a high dose mirtazapine experience is one that is typically described to be completely devoid of insight. In contrast to many other substances with hallucinogenic properties, it produces no introspection, personal problem solving or creativity enhancing effects; for this reason it is generally reported that mirtazapine holds no therapeutic potential when used as a hallucinogen.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
- Sedation - In terms of energy level alterations, mirtazapine is extremely sedating and often results in an overwhelmingly lethargic state. This causes users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness. It is a state which often leaves people feeling extremely lethargic and tired the following day.
- Spontaneous bodily sensations - The "body high" of mirtazapine can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached and is not capable of becoming anything but mildly euphoric even at high dosages. This is accompanied by strange but mild throbbing or aching sensations.
- Tactile hallucination - Unique tactile hallucinations are commonly felt within this substance. These can be described as bizarrely structured vibrations and pulsations that spontaneously manifest themselves across the skin at various locations and propagate outwards for a short distance from its center.
- Changes in felt gravity
- Motor control loss - If physical activities such as walking are forcibly engaged in, a distinct but not completely incapacitating loss of motor control is noticed as well as the consistent feeling that you are walking on top of a trampoline and not a normal solid floor.
- Appetite enhancement - The above components are also accompanied by an intense appetite enhancement that is identical in strength to “the munchies” experienced with cannabis.
- Dry mouth
- Bronchodilation - This can cause swallowing to be extremely difficult and uncomfortable, as with some other anticholinergics such as diphenhydramine. As with diphenhydramine, it is most prominent during the onset phase of the experience and often fades away as the peak sets in.
- Muscle relaxation
- Restless legs - This effect is considered slightly less apparent than it is with diphenhydramine.
- Nausea suppression
- Thought deceleration
- Analysis suppression
- Cognitive euphoria or Cognitive dysphoria - Some reports of recreational mirtazapine use describe mild euphoria, while others either produce a neutral state of mind or dysphoria due to the pronounced side effects.
- Dream potentiation - Dreams becomes more vivid than usual.
- Conceptual thinking
- Immersion enhancement
- Time distortion
- Increased music appreciation
- Emotion suppression - Mirtazapine has a dulling effect on emotions and it is typically difficult to express them.
- Anxiety suppression - This effect is much stronger and more rapidly acting than that of SSRIs.
- Visual acuity suppression
- Tracers - This effect is very common and is more capable of manifesting itself at level 4 than most (if not all) traditional psychedelics.
- Drifting (melting, flowing, breathing and morphing)
- Color tinting
- Color shifting
- Symmetrical texture repetition
- Visual haze
In terms of complexity, the visual geometry found within high dose mirtazapine trips can be said to be completely on par with that of LSD or psilocin. It can be comprehensively described as intricate in complexity, abstract in style, structured in organization, equally organic and synthetic in style, dimly lit in lighting, monotone is scheme, glossy in shading, equal in sharp and soft edges, large in size, fast in speed, smooth in motion, equal in rounded and angular corners, non-immersive in depth and consistent in intensity.
At higher dosages, Level 8A and Level 8B are not present simply because the sedating effects are too overwhelming to allow people to remain conscious at such a high level. Many users report an almost menacing feeling, following a sinister and ominous style with a colour scheme that generally consists of greys and blues.
- External hallucination (Autonomous entities, Settings, sceneries, and landscapes, Perspective alterations and Scenarios and plots) - This effect is very similar to the same experience found within deliriants but does not manifest itself consistently and usually happens only at high dosages. It can be comprehensively described through its variations as delirious in believability, autonomous in controllability and solid in style.
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - The internal hallucinations which mirtazapine induces are generally only present as spontaneous breakthroughs at higher dosages as one is falling asleep. This effect's variations are delirious in believability, interactive in style, new experiences in content, autonomous in controllability and solid in appearance. The most common way in which they manifest themselves are through hypnagogic scenarios which the user may experience as they are drifting off to sleep. These are short and fleeting but frequent and completely believable and convincing as they happen. In terms of the theme they often take the form of bizarre and extremely nonsensical plots. These can also be observed in hypnopompic states (when one is waking from sleep).
- Object activation
- Cannabis - When mirtazapine is combined with cannabis, the euphoric and visual effects are greatly potentiated.
- Psychedelics - Due to mirtazapines action as a 5-HT2A antagonist, it can help reduce the intensity or "abort" a bad trip
Anecdotal reports which describe the effects of this compound within our experience index include:
- Experience: 150mg Mirtazapine (Oral 5x30mg) - Extreme CEVs
- Experience:120mg - Unexpected 'trip', insane CEVs
- Experience:175mg Mirtazapine and 1g D8 Cannabis - Bugs, Lizards and Continuity
- Experience:190mg Mirtazapine - Comparable high to common dose Vicodin
- Experience:210mg Mirtazapine - Psychedelic Delirium
- Experience:Mirtazapine (120mg, Oral) - Extremely sedating and dreamlike CEVs
- Experience:Zopiclone (7.5 mg) + Mirtazapine (7.5 mg) + Cannabis
Additional experience reports can be found here:
Toxicity and harm potential
Mirtazapine is not known to cause brain damage, and has extremely low toxicity relative to dose. Similar to other psychedelic drugs, there are relatively few physical side effects associated with mirtazapine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort.
Dependence and abuse potential
Mirtazapine is not habit-forming when used as a hallucinogen and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of mirtazapine are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption).
Mirtazapine is considered to be relatively safe in the event of an overdose, although it is considered slightly more toxic in overdose than most of the SSRIs (except citalopram). Unlike the TCAs, mirtazapine showed no significant cardiovascular adverse effects at 7 to 22 times the maximum recommended dose. Case reports of overdose with as much as 30 to 50 times the standard dose described the drug as relatively nontoxic, compared to TCAs.
Twelve reported fatalities have been attributed to mirtazapine overdose. The fatal toxicity index (deaths per million prescriptions) for mirtazapine is 3.1 (95% CI: 0.1 to 17.2). This is similar to that observed with SSRIs.
It is strongly recommended that one use harm reduction practices when using this substance.
- Antidepressants - Different types of antidepressants can cause adverse effects as well as possible serotonin syndrome when mixed.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Mirtazapine is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription.
- Switzerland: Mirtazapine is listed as a "Abgabekategorie B" pharmaceutical, which generally requires a prescription.
- Turkey: Mirtazapine is classed as anti-depressant so it is prescription only drug but the law is often unenforced.
- United Kingdom: Mirtazapine is a licensed prescription-only medicine (POM) in the United Kingdom. It is not a criminal offence to possess this medicine without a valid prescription. This medicine can legally be obtained with a valid prescription or through legal import of the medicine for personal use as outlined in Section 13 of the Medicines Act 1968.
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