|Summary sheet: 4-AcO-MET|
|Molecular structure of Metacetin.|
|Common names||4-AcO-MET, 4-Acetoxy-MET, Metacetin, O-Acetylmetocin|
|Systematic name||3-(2-Ethyl(methyl)aminoethyl)-1H-indol-4-yl acetate|
|Routes of Administration|
4-Acetoxy-N-ethyl-N-methyltryptamine (also known as 4-AcO-MET, Metacetin and Azomet) is a novel synthetic psychedelic substance of tryptamine chemical class that produces psilocybin mushroom-like psychedelic effects when administered. 4-AcO-MET possesses a molecular structure and pharmacological effect profile that resemble that of the psilocin-like tryptamine 4-HO-MET (Metocin) which it is thought to act as a prodrug for.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is commonly sold as a research chemical through the use of online vendors. 4-AcO-MET is also occasionally found in pressed pills such as blue diamonds, which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet". This is most likely due to 4-AcO-MET being one of the only few research chemicals that are legal in this country and easily purchasable on research chemical markets.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal issues
- 6 See also
- 7 External links
- 8 References
4-AcO-MET or 4-Acetoxy-N-methyl-N-ethyltryptamine is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-MET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-AcO-MET is an acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT.
4-AcO-MET's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
It is also hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET, although human studies concerning the metabolic fate of this drug are lacking. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.
- Excessive yawning - This component has been observed to occur on most serotonergic psychedelics, but seems especially liable to occur on 4-substituted tryptamines.
- Spontaneous physical sensations - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
- Sedation - Regarding its effects on the physical energy levels of the tripper, 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation.
- Pupil dilation
It's worth noting that this compound still produces visual effects at lower doses without any accompanying cognitive effects or "head space."
- Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, cartooon-like in style, slow and smooth in motion and static in appearance.
- After images
- Colour shifting
- Environmental geometry
- Scenery slicing
- Symmetrical texture repetition
The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Psilocin, 4-AcO-DMT and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-AcO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "natural" and "synthetic" feel to them which is reminiscent of both LSD and Psilocybin. Higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.
4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
The cognitive effects of 4-AcO-MET are described by much as somewhat relaxing, yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.
The most prominent of these typical effects generally include:
- Analysis enhancement
- Conceptual thinking
- Autonomous voice communication
- Ego death
- Emotion enhancement
- Perception of interdependent opposites
- Immersion enhancement
- Increased music appreciation
- Memory suppression
- Novelty enhancement
- Personal bias suppression
- Thought acceleration
- Thought connectivity
- Thought loops
- Time distortion
- Unity and interconnectedness
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-MET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
4-AcO-MET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 4-AcO-MET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
- United States - 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.
- United Kingdom - 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug 4-HO-MET, which is a Class A drug as a result of the tryptamine catch-all clause.
- Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e