Methylnaphthidate

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It may potentially contain incorrect information, particularly regarding that of dosage, duration, subjective effects, toxicity and other risks.

Summary sheet: Methylnaphthidate
Methylnaphthidate
Molecular structure of Methylnaphthidate
Methylnaphthidate.svg
Chemical Nomenclature
Common names Methylnaphthidate, HDMP-28
Substitutive name Methylnaphthidate
Systematic name Methyl (naphthalen-2-yl)(piperidin-2-yl)acetate
Class Membership
Psychoactive class Stimulant
Chemical class Naphthidate / Piperidine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold < 8-10 mg
Light 10 - 15 mg
Common 15 - 30 mg
Strong 30 - 50 mg
Heavy > 50 mg
Duration
Total 2 - 5 hours
Onset 1-10 minutes
Peak 1.5-2 hours
Offset 1-3 hours
After effects 1-8 hours



Insufflated
Dosage
Threshold < 4 mg
Light 4 - 8 mg
Common 8 - 14 mg
Strong 14 - 28 mg
Heavy > 28 mg
Duration
Total 90-180 minutes
Onset 3-6 minutes
Peak 1-2 hours
Offset 1-2 hours
After effects 1-4 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Methylnaphthidate (also known as HDMP-28) is a novel synthetic stimulant substance of the substituted naphthidate and piperidine chemical classes. It is a structural analog of the commonly prescribed ADHD drug methylphenidate (e.g. Ritalin, Concerta) that produces moderately stimulating effects when administered.

Like members of the phenidate class, methylnaphthidate is believed to act as a monoamine reuptake inhibitor.[citation needed] However, it has been reported to display distinct differences in its subjective effects by not behaving as a traditional dopaminergic stimulant. This has been speculated to owe itself to its appreciable effects on serotonin reuptake inhibition that is not observed in typical methylphenidate analogs.[citation needed]

Very little data exists about the pharmacological properties, metabolism, and toxicity of methylnaphthidate, and it has little history of human usage. It is sometimes commercially distributed as a grey-area research chemical by online vendors alongside other methylphenidate analogs like ethylphenidate, isopropylphenidate, and 4F-MPH. It is highly advised to approach this and poorly understood stimulant substance with the proper amount of precaution and harm reduction practices if choosing to use it.

Chemistry

Molecule.svg

This chemistry section is incomplete.

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The main structural differences between methylnaphthidate and methylphenidate in chemical substance is the replacement of the core phenyl ring with with a napthalene group.

Pharmacology

Methylnaphthidate is thought to act primarily as a monoamine triple reuptake inhibitor, meaning it effectively elevates the levels of dopamine, noradrenaline and serotonin neurotransmitters throughout the brain and CNS by binding to and partially blocking the transporter proteins that normally clear out these monoamines from the synaptic cleft. This allows these molecules to accumulate throughout the brain, particularly within the reward pathways in the brain, resulting in stimulating and euphoric effects.

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.


Physical effects
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Cognitive effects
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After effects
Aftereffects (3).svg

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational methylnaphthidate use do not seem to have been studied in any scientific context and the exact toxic and lethal dosages are unknown. This is because methylnaphthidate is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried methylnaphthidate suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent researchshould always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

In terms of its tolerance, methylnaphthidate can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.

While generally considered less recreational, methylnaphthidate has potential for abuse on par with that of amphetamine, cocaine or methylphenidate due to its lack of significant tolerance, euphoric effects and action upon dopamine and serotonin transporters.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal issues

  • United Kingdom - HDMP-28 is a class B drug in the UK as of 31st May 2017 and is illegal to possess, produce or supply. [2]
  • United States: HDMP-28 is not explicitly controlled in the US, but it could possibly be considered an analog of a Schedule II substance (methylphenidate) under the Federal Analog Act.
  • Switzerland: HDMP-28 is illegal in Switzerland as of December 2015.[3]

See also

External links

References

  1. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  2. The Misuse of Drugs Act 1971 (Amendment) Order 2017 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2017/634/made
  3. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien". Der Bundesrat.