Talk:3-CMC

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3-CMC has the potential to cause serious injury and death.

Ten deaths have been confirmed via biological samples from using this substance.[1] Six are from polydrug use (alcohol, opioids, synthetic cannabinoids and benzodiazepines). It is strongly discouraged to take higher doses of this substance or to insufflate (snort) it.

3-CMC
3-CMC.svg
Chemical Nomenclature
Common names 3-CMC, Clophedrone, Crystal
Substitutive name 3-Chloromethcathinone
Systematic name 1-(3-Chlorophenyl)-2-(methylamino)-1-propanone
Class Membership
Psychoactive class Stimulant / Entactogen
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 30 mg
Light 30 - 60 mg
Common 60 - 100 mg
Strong 100 - 180 mg
Heavy 180 - 250 mg +
Duration
Total 1 - 5 hours
Onset 10 - 30 minutes
Come up 5 - 15 minutes
Peak 20 - 120 minutes
Offset 1 - 3 hours
After effects 2 - 6 hours



Insufflated
Dosage
Threshold 20 mg
Light 20 - 50 mg
Common 50 - 85 mg
Strong 85 - 130 mg
Heavy 130-200 mg +
Duration
Total 1 - 2 hours
Onset 5 - 8 minutes
Come up 1 - 5 minutes
Peak 20 - 90 monites
Offset 1 - 2 hours
After effects 1 - 1.5 hours
Rectal
Dosage
Bioavailability ~ +90%
Threshold 30 mg
Light 30 - 40 mg
Common 40 - 80 mg
Strong 80 - 120 mg
Heavy 120-180 mg +
Duration
Total 1 - 2 hours
Onset 1 - 15 minutes
Come up 5 - 10 minutes
Peak 20 - 60 minutes
Offset 30 - 90 minutes
After effects 60 - 90 minutes





DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

3-Chloromethcathinone (also known as 3-CMC or clophedrone [2]) is a novel stimulant-entactogen substance of the cathinone class. It is the analogue of 3-Chloromethamphetamine (3-CMA) and structurally closely related to the antidepressant and anti-addictive medication bupropion. The complete working has not been fully studied, however it is known to promote the release of dopamine, noradrenaline and serotonin just like other Methcathinone substances.[3] [4]

3-CMC has been sold online on the research chemical market as a designer drug since 2013 in mainly European countries[5]. 3-CMC has been marketed as the legal successor of 3-MMC in the Netherlands since its ban in October 2021 [6].

The subjective effects are reported to be similar, but weaker, to those of 3-MMC. This mostly includes stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, increased libido, and euphoria. It is also reported to be subject to compulsive redosing which can lead to psychosis and habitual use.

The related 4-CMC is a known neurotoxin, and research shows that 3-CMC is neurotoxic in mice[7]. If 3-CMC's mechanism of action is inherently neurotoxic then damage to human health may be incurred even at moderate recreational doses. Anecdotal reports mention highly concerning cardiovascular and neurological symptoms after frequent or common-high dose use, which seem to confirm this suspicion. As such it is advised to avoid completely, and to use excessive harm reduction practices if planning on using this substance.


Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.


Physical effects
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Cognitive effects
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After effects
Aftereffects (3).svg


Added & revised subjective effects. Chinker24 (talk) 00:11, 19 January 2023 (UTC)

References

  1. Christie, R., Duque, P., Evans-Brown, M., Gallegos, A., Jorge, R., De Morais, J., Planchuelo, G., Sedefov, R. (26 August 2022). "EMCDDA initial report on the new psychoactive substance 1-(3-chlorophenyl)-2-(methylamino) propan-1-one (3-chloromethcathinone, 3-CMC)" (PDF). European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). ISSN 2600-0954. 
  2. WRZESIEŃ, W., STANASZEK, R., ZUBA, D., BYRSKA, B. (2018). Clandestine laboratory producing mephedrone (4-MMC) and Clephedrone (4-CMC) – substance, identification and hazard analysis, 40, 287-309. http://www.forensicscience.pl/pfs/115_Wrzesien_m.pdf.
  3. National Center for Biotechnology Information (2022). PubChem Bioassay Record for AID 1224711, Source: ChEMBL. Retrieved January 16, 2022 from https://pubchem.ncbi.nlm.nih.gov/bioassay/1224711.
  4. National Center for Biotechnology Information (2022). PubChem Bioassay Record for AID 1224713, Source: ChEMBL. Retrieved January 16, 2022 from https://pubchem.ncbi.nlm.nih.gov/bioassay/1224713.
  5. Odoardi S, Romolo FS, Strano-Rossi S (August 2016). "A snapshot on NPS in Italy: Distribution of drugs in seized materials analyzed in an Italian forensic laboratory in the period 2013-2015". Forensic Science International. 265: 116–20. doi:10.1016/j.forsciint.2016.01.037. PMID 26874736. 
  6. Tactus Verslavingszorg is bezorgd, want de verboden partydrug 3-MMC heeft al een legale opvolger: 3-CMC
  7. Wojcieszak, Jakub & Kuczyńska, Katarzyna & Zawilska, Jolanta. (2020). Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles. Neurotoxicity Research. 38. 10.1007/s12640-020-00227-8.