Talk:3-CMC

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3-CMC
3-CMC.svg
Chemical Nomenclature
Common names 3-CMC, Clophedrone
Substitutive name 3-Chloromethcathinone
Systematic name 1-(3-Chlorophenyl)-2-(methylamino)-1-propanone
Class Membership
Psychoactive class Stimulant / Entactogen
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 30 mg
Light 30 - 60 mg
Common 60 - 100 mg
Strong 100 - 180 mg
Heavy 180 mg +
Duration
Total 2 - 6 hours
Onset 10 - 30 minutes
Come up 30 - 60 minutes
Peak 2 - 4 hours
Offset 1 - 1.5 hours
After effects 2 - 12 hours



Insufflated
Dosage
Threshold 20 mg
Light 20 - 40 mg
Common 40 - 80 mg
Strong 80 - 100 mg
Heavy 100 mg +
Duration
Total 1 - 2 hours
Onset 5 - 10 minutes
Come up 10 - 30 minutes
Peak 1 - 1.5 hours
Offset 1 - 2 hours
After effects 1 - 1.5 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

3-Chloromethcathinone (also known as 3-CMC or clophedrone [1]) is a novel stimulant-entactogen substance of the cathinone class. It is the analogue of the neurotoxic 4-CA and structurally closely related to the antidepressant and anti-addictive medication bupropion. The complete working has not been fully studied, however it is known to promote the release of dopamine and serotonin.[2] [3]

3-CMC has been sold online on the research chemical market as a designer drug since 2013 in mainly European countries[4]. 3-CMC has been marketed as the legal successor of 3-MMC in the Netherlands since its ban in oktober 2021 [5].

The subjective effects are reported to be similar, but weaker, to those of 3-MMC. This mostly includes stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, increased libido, and euphoria. It is also reported to be subject to compulsive redosing and habitual use.

Since the related 4-CA and 4-CMC are known neurotoxins and research shows that 3-CMC is neurotoxic in mice[6]. It is highly advised to be avoided or use harm reduction practices if still planning on using this substance.

References

  1. WRZESIEŃ, W., STANASZEK, R., ZUBA, D., BYRSKA, B. (2018). Clandestine laboratory producing mephedrone (4-MMC) and Clephedrone (4-CMC) – substance, identification and hazard analysis, 40, 287-309. http://www.forensicscience.pl/pfs/115_Wrzesien_m.pdf.
  2. National Center for Biotechnology Information (2022). PubChem Bioassay Record for AID 1224711, Source: ChEMBL. Retrieved January 16, 2022 from https://pubchem.ncbi.nlm.nih.gov/bioassay/1224711.
  3. National Center for Biotechnology Information (2022). PubChem Bioassay Record for AID 1224713, Source: ChEMBL. Retrieved January 16, 2022 from https://pubchem.ncbi.nlm.nih.gov/bioassay/1224713.
  4. Odoardi S, Romolo FS, Strano-Rossi S (August 2016). "A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015". Forensic Science International. 265: 116–20. doi:10.1016/j.forsciint.2016.01.037. PMID 26874736. 
  5. Tactus Verslavingszorg is bezorgd, want de verboden partydrug 3-MMC heeft al een legale opvolger: 3-CMC
  6. Wojcieszak, Jakub & Kuczyńska, Katarzyna & Zawilska, Jolanta. (2020). Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-α-Pyrrolidinopentiophenone, and 4-Methoxy-α-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles. Neurotoxicity Research. 38. 10.1007/s12640-020-00227-8.