Talk:3-CMC

3-CMC has the potential to cause serious injury and death.

Ten deaths have been confirmed via biological samples from using this substance. Six are from polydrug use (alcohol, opioids, synthetic cannabinoids and benzodiazepines). It is strongly discouraged to take higher doses of this substance or to insufflate (snort) it.

3-CMC
Chemical Nomenclature
Common names	3-CMC, Clophedrone
Substitutive name	3-Chloromethcathinone
Systematic name	1-(3-Chlorophenyl)-2-(methylamino)-1-propanone
Class Membership
Psychoactive class	Stimulant / Entactogen
Chemical class	Cathinone
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 30 mg Light 30 - 60 mg Common 60 - 100 mg Strong 100 - 180 mg Heavy 180 - 250 mg + Duration Total 1 - 5 hours Onset 10 - 30 minutes Come up 5 - 15 minutes Peak 20 - 120 minutes Offset 1 - 3 hours After effects 2 - 6 hours ⇣ Insufflated Dosage Threshold 20 mg Light 20 - 50 mg Common 50 - 85 mg Strong 85 - 130 mg Heavy 130-200 mg + Duration Total 1 - 2 hours Onset 5 - 8 minutes Come up 1 - 5 minutes Peak 20 - 90 minutes Offset 1 - 2 hours After effects 1 - 1.5 hours ⇣ Rectal Dosage Bioavailability ~ +90% Threshold 30 mg Light 30 - 40 mg Common 40 - 80 mg Strong 80 - 120 mg Heavy 120-180 mg + Duration Total 1 - 2 hours Onset 1 - 15 minutes Come up 5 - 10 minutes Peak 20 - 60 minutes Offset 30 - 90 minutes After effects 60 - 90 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

3-Chloromethcathinone (also known as 3-CMC or clophedrone ) is a novel stimulant-entactogen substance of the cathinone class. It is the analogue of 3-Chloromethamphetamine (3-CMA) and structurally closely related to the antidepressant and anti-addictive medication bupropion. The subjective effects are reported to be similar, but weaker, to those of 3-MMC. This mostly includes stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, increased libido, and euphoria. It is also reported to be subject to compulsive redosing which can lead to psychosis and habitual use.

History and culture

3-CMC has been sold online on the research chemical market as a designer drug since 2013 in mainly European countries. 3-CMC has been marketed as the legal successor of 3-MMC in the Netherlands since its ban in October 2021 .

Pharmacology

The pharmacology of 3-CMC has not been fully studied, however it is known to promote the release of dopamine, noradrenaline and serotonin similar to other substituted methcathinones.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Stimulation - The stimulation is heavily increased when combined with alcohol, however, this is not recommended due to its potential for harm. Paradoxically, the stimulation may be less pronounced at higher doses.
  • Spontaneous bodily sensations
    • Physical euphoria - This is more likely to occur in higher doses, or when taken orally.
  • Appetite suppression
  • Teeth grinding
  • Abnormal heartbeat
    • Increased heart rate
    • Increased blood pressure
  • Vasoconstriction - This is reported to be less pronounced with an oral ROA at low - medium doses.

Cognitive effects

• • Cognitive euphoria - Similar to the physical euphoria, this is more likely to occur in higher doses, or when taken orally.
  • Compulsive redosing - Be careful if redosing this substance as it can lead to extreme cases of vasoconstriction.
  • Focus enhancement
  • Increased libido
  • Decreased libido *Increased music appreciation
  • Uncomfortable physical effects
  • Psychosis
    • Paranoia
    • Delusions
  • Irritability
  • Memory suppression - After a few doses, memory becomes impaired in fashion to the MDMA comedown, if more doses are ingested it can be hard to even remember what you are talking about mid sentence.
  • Motivation enhancement
  • Thought acceleration
  • Thought organization
  • Time distortion
  • Wakefulness
  • Confusion - This can be described as being "fried" and it can be hard to even form thoughts properly. This effect usually appears at higher dosage after the first or second peak has passed.

After effects

• • Delusions
    • Anxiety - Can cause severe anxiety, especially if coupled with psychosis or repeated dosages.
  • Appetite suppression
  • Irritability
  • Wakefulness
  • Cognitive fatigue
  • Low blood pressure - This effect is reported by some experience reports, the cathinone family's known vasoconstriction coupled with this can lead to numbness and pale face and hands.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

• Erowid Experience Vaults: 3-CMC

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

3-CMC's isomer 4-CMC is a known neurotoxin, and research shows that 3-CMC is neurotoxic in mice. If 3-CMC's mechanism of action is inherently neurotoxic then damage to human health may be incurred even at moderate recreational doses. Anecdotal reports mention highly concerning cardiovascular and neurological symptoms after frequent or high-dose use, which seems to confirm this suspicion.

It is strongly advised to avoid this substance completely. Use excessive harm reduction practices if planning on using this substance, and avoid redosing.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

While 3-CMC is not controlled under the United Nations Single Convention on Narcotic Drugs, 1961, nor under the Convention on Psychotropic Substances of 1971. it is subject to restrictive measures in 21 Member States of the European Union: Croatia, Czechia, Denmark, Estonia, France, Italy, Ireland, Latvia, Poland, Portugal, Slovenia, Slovakia, and Sweden.

• China: Is considered a narcotic substance since 2015
• France: As a derivative of cathinone with a halogen substitution on the phenyl group, 3-CMC is scheduled as a "stupéfiant", i.e. a recognized drug of abuse. It is illegal to possess, buy, sell or manufacture.
• The Netherlands: Since 2023-09-12, 3-CMC is classified as a "List 1" drug which makes it illegal.

See also

• Responsible use
• Stimulant
• Substituted cathinones
• 3-MMC
• 4-MMC

External links

• 3-CMC (Wikipedia)
• 3-CMC (Isomer Design)

References

Added & revised subjective effects. Chinker24 (talk) 00:11, 19 January 2023 (UTC) Added legal status User:Bernkastel - needs to be conventionalized.