Talk:3-CMC

3-CMC has the potential to cause serious injury and death.

Ten deaths have been confirmed via biological samples from using this substance. Six are from polydrug use (alcohol, opioids, synthetic cannabinoids and benzodiazepines). It is strongly discouraged to take higher doses of this substance or to insufflate (snort) it.

3-CMC
Chemical Nomenclature
Common names	3-CMC, Clophedrone, Crystal
Substitutive name	3-Chloromethcathinone
Systematic name	1-(3-Chlorophenyl)-2-(methylamino)-1-propanone
Class Membership
Psychoactive class	Stimulant / Entactogen
Chemical class	Cathinone
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 30 mg Light 30 - 60 mg Common 60 - 100 mg Strong 100 - 180 mg Heavy 180 - 250 mg + Duration Total 1 - 5 hours Onset 10 - 30 minutes Come up 5 - 15 minutes Peak 20 - 120 minutes Offset 1 - 3 hours After effects 2 - 6 hours ⇣ Insufflated Dosage Threshold 20 mg Light 20 - 50 mg Common 50 - 85 mg Strong 85 - 130 mg Heavy 130-200 mg + Duration Total 1 - 2 hours Onset 5 - 8 minutes Come up 1 - 5 minutes Peak 20 - 90 monites Offset 1 - 2 hours After effects 1 - 1.5 hours ⇣ Rectal Dosage Bioavailability ~ +90% Threshold 30 mg Light 30 - 40 mg Common 40 - 80 mg Strong 80 - 120 mg Heavy 120-180 mg + Duration Total 1 - 2 hours Onset 1 - 15 minutes Come up 5 - 10 minutes Peak 20 - 60 minutes Offset 30 - 90 minutes After effects 60 - 90 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

3-Chloromethcathinone (also known as 3-CMC or clophedrone ) is a novel stimulant-entactogen substance of the cathinone class. It is the analogue of 3-Chloromethamphetamine (3-CMA) and structurally closely related to the antidepressant and anti-addictive medication bupropion. The complete working has not been fully studied, however it is known to promote the release of dopamine, noradrenaline and serotonin just like other Methcathinone substances.

3-CMC has been sold online on the research chemical market as a designer drug since 2013 in mainly European countries. 3-CMC has been marketed as the legal successor of 3-MMC in the Netherlands since its ban in October 2021 .

The subjective effects are reported to be similar, but weaker, to those of 3-MMC. This mostly includes stimulation, anxiety suppression, disinhibition, enhanced empathy and sociability, relaxation, increased libido, and euphoria. It is also reported to be subject to compulsive redosing which can lead to psychosis and habitual use.

The related 4-CMC is a known neurotoxin, and research shows that 3-CMC is neurotoxic in mice. If 3-CMC's mechanism of action is inherently neurotoxic then damage to human health may be incurred even at moderate recreational doses. Anecdotal reports mention highly concerning cardiovascular and neurological symptoms after frequent or common-high dose use, which seem to confirm this suspicion. As such it is advised to avoid completely, and to use excessive harm reduction practices if planning on using this substance.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Stimulation - The stimulation is heavily increased when combined with alcohol however this is not recommended for harm reduction. At higher doses the stimulation becomes less pronounced.
  • Spontaneous bodily sensations
    • Physical euphoria - This is more present in heavy doses or with oral dosing.
  • Appetite suppression
  • Teeth grinding - The user usually only have this effect during the first dose, unless redoses are increasingly higher.
  • Abnormal heartbeat
    • Increased heart rate
    • Increased blood pressure
  • Vasoconstriction - This is reported to be less pronounced with an oral ROA at low - medium doses.

Cognitive effects

• • Cognitive euphoria - This effect, just like the physical euphoria, but thought to be exhibited to a higher degree when dosing orally.
  • Compulsive redosing - Be careful with redosing this substance as it can lead to extreme cases of vasoconstriction.
  • Focus enhancement
  • Increased libido
  • Decreased libido *Increased music appreciation
  • Uncomfortable physical effects
  • Psychosis
    • Paranoia
    • Delusions
  • Irritability
  • Memory suppression - After a few doses, memory becomes impaired in fashion to the MDMA comedown, if more doses are ingested it can be hard to even remember what you are talking about mid sentence.
  • Motivation enhancement
  • Thought acceleration
  • Thought organization
  • Time distortion
  • Wakefulness
  • Confusion - This can be described as being "fried" and it can be hard to even form thoughts properly. This effect usually appears at higher dosage after the first or second peak has passed.

After effects

• • Delusions
    • Anxiety - Can cause severe anxiety, especially if coupled with psychosis or repeated dosages.
  • Appetite suppression
  • Irritability
  • Wakefulness
  • Cognitive fatigue
  • Low blood pressure - This effect is reported by some experience reports, the cathinone family's known vasoconstriction coupled with this can lead to numbness and pale face and hands.

Added & revised subjective effects. Chinker24 (talk) 00:11, 19 January 2023 (UTC)