Talk:Zaleplon

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Death may result when GABAergic substances are combined with other depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or alcohol.[1]

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

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This page has not been approved by the PsychonautWiki administrators.

It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks.

Summary sheet: Zaleplon
Zaleplon
Zaleplon.svg
Chemical Nomenclature
Common names Sonata, Starnoc, Andante
Substitutive name Zaleplon
Systematic name N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
Class Membership
Psychoactive class Depressant / Hallucinogen
Chemical class Pyrazolopyrimidine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 5 mg
Light 10 - 30 mg
Common 30 - 60 mg
Strong 60 - 100 mg
Heavy 100 mg +
Duration
Total 90 - 120 minutes
Onset 5 - 15 minutes
Peak 30 - 60 minutes
Offset 10 - 20 minutes
After effects 2 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Zaleplon (trade name Sonata) is a non-benzodiazepine hypnotic drug. It is of the hypnotic and depressant psychoactive classes and is chemically a pyrazolopyrimidine. When taken for recreational purposes, at doses far higher then the prescribed dose, it is capable of producing powerful and bizarre atypical hallucinogenic, hypnotic, deliriant and even psychedelic effects. Some individuals use a different delivery method than prescribed, such as insufflation, to induce effects faster

Zaleplon is a member of a family known as "Z-drugs." Other Z-drugs include Zolpidem (Ambien) and zopiclone. These drugs were initially thought to be less addictive and/or habit-forming than benzodiazepines. However, this evaluation has shifted in the last few years as cases of addiction and habituation have accumulated.[citation needed]

Zaleplon is recommended to be taken on a short-term basis only. Daily or continuous use of the drug is not usually advised.

History and culture

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Chemistry

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Zaleplon is a pyrazolopyrimidine having a nitrile group at position 3 and a 3-(N-ethylacetamido)phenyl substituent at the 7-position.

Pharmacology

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Zaleplon has a pharmacological profile similar to benzodiazepines. Zaleplon is a full agonist for the benzodiazepine a1 receptor located on the GABAA receptor ionophore complex in the brain, with lower affinity for the a2 and a3 subtypes. It selectively enhances the action of GABA similar to but more selectively than benzodiazepines.[2]

In regards to how the consumption of this compound results in its bizarre hallucinations, the pharmacological mechanics behind this are not understood and do not seem to have been directly studied. It is worth noting, however, that zaleplon may share similar mechanisms as a GABAA receptor agonist to that of muscimol, which is the active compound within the hallucinogenic amanita muscaria mushroom.

Subjective effects

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Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Disconnective effects
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Visual effects
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Cognitive effects
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Auditory effects
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Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

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We also recommend that you conduct independent research and use harm reduction practices when using this substance.

By itself, zaleplon likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like benzodiazepines, alcohol or opioids.[2]

As with other Z-drugs, zaleplon use may result in bizarre and dangerous behavior.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

Zaleplon is moderate physically and psychologically addictive.

Tolerance will develop to the sedative-hypnotic effects within a couple of weeks of daily use. After cessation, the tolerance returns to baseline in 7 - 14 days. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction.


Dangerous interactions

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Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

  • Stimulants - It can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

Legal status

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  • United States - Zaleplon is Schedule IV under the Controlled Substance Act (CSA), meaning it is judged to have "some potential for abuse."" Possession without a prescription is illegal.
  • Canada - Zaleplon is not scheduled in Canada. However, it may be illegal to possess without a valid prescription. [citation needed]
  • Russia: Zaleplon is available through a prescription.[citation needed]

See also

External links

Literature

References

  1. Risks of Combining Depressants (Tripsit) | https://tripsit.me/combining-depressants/
  2. 2.0 2.1 2.2 2.3 Profiles of Drug Substances, Excipients and Related Methodology | https://www.sciencedirect.com/science/article/pii/S1871512510350084
  3. Ambien Linked to 'Sleep Eating' | http://www.webmd.com/sleep-disorders/news/20060315/ambien-linked-to-sleep-eating
  4. Ambien, delusions, and violence: Is there a link? | https://www.psychologytoday.com/blog/the-measure-madness/201005/ambien-delusions-and-violence-is-there-link
  5. Ambien Side Effects Center (rxlist) | http://www.rxlist.com/ambien-side-effects-drug-center.htm