|Summary sheet: Yohimbine|
|Common names||Yohimbine, Yocon, Yocoral or quebrachine|
|Systematic name||methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate|
|Chemical class||Indole alkaloid|
|Routes of Administration|
Yohimbine (also known as quebrachine) is a naturally-occurring stimulant substance of the indoloquinolizidine class. It has various uses including as an aphrodisiac and a weight loss agent. Most often, yohimbine is used in the form of hydrochloride.
Yohimbine, an alpha-2 adrenergic receptor antagonist, is an indole alkaloid found in numerous botanical sources. It is the predominant alkaloid in extracts from the bark of the Pausinystalia johimbe tree, and can also be found in Rauwolfia root. Many of its effects are attributed to its α2-adrenergic receptor antagonist activity, which increases central sympathetic outflow and raises blood pressure, heart rate, and norepinephrine levels.
While some reviewers noted that this extract did help them maintain an erection, lose weight or increase their energy level, many noted that the side effects they experienced outweighed any benefits they received. Some took a dosage that was considerably lower than recommended and still had unwanted side effects.
Yohimbine is an indole alkaloid molecule of the indoloquinolizidine chemical class. Analyses of yohimbe bark indicate that the average total indole alkaloid content is approximately 3–6%, with approximately 10–15% of the alkaloids being yohimbine; in addition to yohimbine and its isomers (α-yohimbine, β-yohimbine, allo-yohimbine), these alkaloids include ajmaline, dihydroyohimbine, corynantheidine, dihydrocorynantheine, and corynanthine (rauhimbin).
Most often, yohimbine is used in the form of hydrochloride.
The primary and most researched mechanism of yohimbine is antagonism of a class of receptors known as alpha-2 adrenergic receptors, thus it increases noradrenaline levels by preventing their uptake into subsequent neurons. Blocking alpha-2 adrenoceptors increases blood pressure, releases insulin, and decreases blood sugar levels. Yohimbine also, however, blocking alpha-1 adrenergic receptors, albeit with lower affinity. It also has been shown to weak inhibit monoamine oxidase.
|This subjective effects section is a stub.|
As such, it is still in progress and may contain incomplete or wrong information.
You can help by expanding or correcting it.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.
Yohimbine pretty much gives body energy while doing very little for mind.
- Appetite suppression
- Frequent urination
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Increased salivation - The mechanism by which yohimbine increases submaxillary secretion appears to involve inhibition of presynaptic a2-ARs located on the chorda tympani, which inhibit cholinergic transmission.
- Pupil dilation
- Seizures - In extremely high dose, yohimbine can induce seizures.
- Stamina enhancement
- Stimulation - In terms of its effects on the physical energy levels of the user, yohimbine is usually considered to be mildly to moderately energetic and stimulating in a fashion that is considerably weaker in comparison to that of traditional recreational stimulants such as amphetamine or cocaine, but stronger than caffeine.
- Tactile enhancement
- Analysis enhancement
- Anxiety - Yohimbine exerts a stimulating action on the emotions and may increase anxiety.
- Cognitive dysphoria
- Cognitive euphoria - Generally, this effect is rare and less pronounced than with classical stimulants.
- Disinhibition - Yohimbine can increase impulsivity.
- Dream potentiation - Many users report that yohimbine in a dosage of up to 1 mg has a positive effect on the brightness of sleep and its memory.
- Ego inflation
- Emotion enhancement - Yohimbine makes whatever cognitive, especially emotional, sensation more intense. That sensation intensified could be positive or negative, it just depends on the context.
- Increased libido
- Motivation enhancement - Yohimbine can get motivation and mood levels up.
- Thought acceleration
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
Yohimbine has a low toxicity relative to dose. Various studies have shown that in reasonable doses in a careful context, it presents few negative cognitive, psychiatric or toxic physical consequences, though some exist. The side effects of yohimbine are clearly dose-dependent, are generally apparent at doses much higher than the claimed therapeutic doses. Generally all reported side effects of yohimbine are reversible and resolve spontaneously within a relatively short time after termination of the drug therapy, and most individuals who experience the inadvertent use of toxic doses will recover after a relatively short period of expectant restoration, which is measured in hours. Deaths from yohimbine overdosing are uncommonly reported but nonetheless published. Higher doses (200 – 5,000 mg) result in stronger side effects and can be toxic to the brain. Extremely high doses (above 5,000 mg) can be lethal.
Not recommended for individuals who have bleeding conditions as it can increase the risk of bleeding. For this reason, it is also dangerous for individuals who recently had a surgery. For those already taking this supplement, it is advised to stop intake two weeks before the scheduled surgery.
It is strongly recommended that one be familiar with harm reduction practices when using this drug.
Dependence and abuse potential
Yohimbine is not known to be not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of yohimbine are quickly built after repeated and frequent usage. After that, it takes about 7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). Yohimbine does not produce cross-tolerance with most other stimulants.
Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- 25x-NBOMe & 25x-NBOH - Members of the 25x family are highly stimulating and physically straining. Combinations with stimulants should be avoided due to the risk of excessive stimulation. This can result in panic attacks, thought loops, seizures, increased blood pressure, vasoconstriction, and heart failure in extreme cases.
- Alcohol - Alcohol can be dangerous to combine with stimulants due to the risk of accidental over-intoxication. Stimulants mask the sedative effects of alcohol, which is the main factor people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects of alcohol are left unopposed, which can result in blackouts and respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - Combinations with DXM should be handled with extreme care due to DXM's effects on serotonin and norepinephrine reuptake. This can lead to panic attacks, hypertensive crisis, or serotonin syndrome with stimulants that increase levels of serotonin (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
- MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants. There is also a risk of excessive heart strain.
- MXE - Combinations with MXE may dangerously elevate blood pressure and increase the risk of psychosis.
- Stimulants - Yohimbine can be potentially dangerous in combination with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
- Tramadol - Tramadol lowers the seizure threshold. Combinations with stimulants may further increase this risk.
- MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Yohimbine is legal in nearly all parts of the world.
- Yohimbine | https://www.sciencedirect.com/science/article/pii/B9780128012383988627
- Interactions between Nutraceuticals/Nutrients and Therapeutic Drugs | https://www.sciencedirect.com/science/article/pii/B9780128021477000607
- Encyclopedia of Toxicology. Yohimbine | https://www.sciencedirect.com/science/article/pii/B9780123864543007995
- Encyclopedia of Toxicology | https://www.sciencedirect.com/science/article/pii/B9780123864543007995
- Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/10611634
- Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/6145164
- Reference Module in Biomedical Sciences | https://www.sciencedirect.com/science/article/pii/B9780128012383988627
- Yohimbine: a clinical review | https://www.sciencedirect.com/science/article/pii/S0163725801001565
- Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/9004342
- An Overview of Yohimbine in Sports Medicine | https://www.sciencedirect.com/science/article/pii/B9780128054130000156
- Case study: two fatal case reports of acute yohimbine intoxication. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/23846025
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183.
- Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi: . eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647.