3',4'-Methylenedioxy-α-pyrrolidinohexiophenone (also known as MDPHP and Monkey Dust) is a synthetic entactogenic stimulant of the Substituted cathinone class, and its commonly reported effects include stimulation, disinhibition, increased libido, compulsive redosing, and euphoria when administered orally, insufflated or smoked.
Like other Substituted cathinones, MDPHP is associated with compulsive use and addiction. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPHP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use harm reduction practices if choosing to use this substance.
Substituted cathinones are derivatives of the naturally occurring substance cathinone, which is one of the psychoactive principles in khat (Catha edullis). Cathinone is composed of a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon.
MDPHP is thought to act primarily as a potent norepinephrine-dopamine reuptake inhibitor (NDRI). Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this inhibition is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. Serotonin also plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that MDPHP produces. Mainly possessing re-uptake inhibiting qualities, MDPHP could be considered more like cocaine or methylphenidate than amphetamine in method of action. In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.
However, despite its structural similarity, the effects of MDPHP bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily stimulant effects with only mild entactogenic qualities. It is closely related to the potent stimulant MDPV though with slightly milder effects and lesser compulsive redosing cravings. Although MDPHP was already first synthetized in 1960's, it has been used as an alternative in some countries following the banning of MDPV.
- Substituted cathinones
- Methylenedioxypyrovalerone (MDPV)
- α-Pyrrolidinohexiophenone (α-PHP)
- 3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP)