Thought disorganization

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Thought disorganization is defined as a state in which one's ability to analyze and categorize conceptual information using a systematic and logical thought process is considerably decreased. It seemingly occurs through an increase in thoughts which are unrelated or irrelevant to the topic at hand, thus decreasing one's capacity for a structured and cohesive thought stream. This effect also seems to allow the user to hold a significantly lower amount of relevant information in their train of thought which can be useful for extended mental calculations, articulating ideas, and analyzing logical arguments.

Thought disorganization is often accompanied by other coinciding effects such as analysis depression and thought acceleration. It is most commonly induced under the influence of heavy dosages of hallucinogenic and depressant compounds, such as dissociatives,[1][2][3][4] psychedelics,[1][5] cannabinoids,[1][6][7] and GABAergics.[8][9] However, it is worth noting that the same stimulant or nootropics compounds which induce thought organization at lower dosages, can also often result in the opposite effect of thought disorganization at their higher dosages.[1][9][10][11]

Psychoactive substances

Compounds within our psychoactive substance index which may cause this effect include:

Experience reports

Anecdotal reports which describe this effect within our experience index include:

See also

External links


  1. 1.0 1.1 1.2 1.3 Murray, Robin M.; Morrison, Paul D.; Di Forti, Marta; Paparelli, Alessandra (2011). "Drug-Induced Psychosis: How to Avoid Star Gazing in Schizophrenia Research by Looking at More Obvious Sources of Light". Frontiers in Behavioral Neuroscience. 5. doi:10.3389/fnbeh.2011.00001. ISSN 1662-5153. 
  2. Flohr, H., Glade, U., Motzko, D. (1998). "The neural correlate of consciousness and the mechanisms of general anaesthesia". Toxicology Letters. 100: 23–29. 
  3. Flohr, H.; Glade, U.; Motzko, D. (1998). "The role of the NMDA synapse in general anesthesia". Toxicology Letters. 100-101: 23–29. doi:10.1016/S0378-4274(98)00161-1. ISSN 0378-4274. 
  4. Lahti, A (2001). "Effects of Ketamine in Normal and Schizophrenic Volunteers". Neuropsychopharmacology. 25 (4): 455–467. doi:10.1016/S0893-133X(01)00243-3. ISSN 0893-133X. 
  5. Winkelman, Michael J. (2017). "The Mechanisms of Psychedelic Visionary Experiences: Hypotheses from Evolutionary Psychology". Frontiers in Neuroscience. 11. doi:10.3389/fnins.2017.00539. ISSN 1662-453X. 
  6. D’Souza, Deepak Cyril; Sewell, Richard Andrew; Ranganathan, Mohini (2009). "Cannabis and psychosis/schizophrenia: human studies". European Archives of Psychiatry and Clinical Neuroscience. 259 (7): 413–431. doi:10.1007/s00406-009-0024-2. ISSN 0940-1334. 
  7. Radhakrishnan, Rajiv; Wilkinson, Samuel T.; D’Souza, Deepak Cyril (2014). "Gone to Pot â€" A Review of the Association between Cannabis and Psychosis". Frontiers in Psychiatry. 5. doi:10.3389/fpsyt.2014.00054. ISSN 1664-0640. 
  8. Bennett, W. R. Murray; Wilson, Lawrence G.; Roy-Byrne, Peter P. (2007). "Gamma-Hydroxybutyric Acid (GHB) Withdrawal: A Case Report". Journal of Psychoactive Drugs. 39 (3): 293–296. doi:10.1080/02791072.2007.10400616. ISSN 0279-1072. 
  9. 9.0 9.1 Tsuang, Ming T. (1982). "Subtypes of Drug Abuse With Psychosis". Archives of General Psychiatry. 39 (2): 141. doi:10.1001/archpsyc.1982.04290020013003. ISSN 0003-990X. 
  10. Angrist, Burton; Thompson, Hyacinth; Shopsin, Baron; Gershon, Samuel (1975). "Clinical studies with dopamine-receptor stimulants". Psychopharmacologia. 44 (3): 273–280. doi:10.1007/BF00428906. ISSN 0033-3158. 
  11. Krystal, John H.; Perry, Edward B.; Gueorguieva, Ralitza; Belger, Aysenil; Madonick, Steven H.; Abi-Dargham, Anissa; Cooper, Thomas B.; MacDougall, Lisa; Abi-Saab, Walid; D’Souza, D. Cyril (2005). "Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine". Archives of General Psychiatry. 62 (9): 985. doi:10.1001/archpsyc.62.9.985. ISSN 0003-990X.