Methiopropamine

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Summary sheet: Methiopropamine
Methiopropamine
Molecular structure of Methiopropamine
Methiopropamine.svg
Chemical Nomenclature
Common names MPA
Substitutive name Methiopropamine
Systematic name 1-(Thiophen-2-yl)-2-methylaminopropane
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 10 - 20 mg
Light 20 - 30 mg
Common 30 - 50 mg
Strong 50 - 60 mg
Heavy 60 mg +
Duration
Total 6 - 10 hours
Onset 30 - 60 minutes
Peak 2 - 4 hours
Offset 2 - 3 hours
After effects 1 - 2 hours



Insufflated
Dosage
Threshold 5 mg
Light 5 - 20 mg
Common 20 - 40 mg
Strong 40 - 60 mg
Heavy 60 mg +
Duration
Total 2 - 4 hours
Onset 5 - 10 minutes
Come up 5 - 10 minutes
Peak 30 - 60 minutes
Offset 30 - 120 minutes
After effects 6 - 8 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Methiopropamine (MPA) is a thiophene ring-based structural analogue of methamphetamine which was originally reported in 1942.[1] Chemically, it is not a phenethylamine or amphetamine, nor is it their functional analog. It originally appeared for public sale in the U.K. in December 2010 as a research chemical or legal high, recently branded as "Blow".[2] It has limited popularity as a recreational stimulant.[3]

Chemistry

Methiopropamine, or 1-(thiophen-2-yl)-2-methylaminopropane, is a synthetic molecule of the thiophene class. It is a structural analogue to methamphetamine. It contains a thiophene ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Methiopropamine contains an additional methyl substitution at RN (similarly to MDMA and methamphetamine). Although methiopropamine is analogous to methamphetamine, it is neither an amphetamine nor a phenethylamine as methiopropamine contains a thiophene ring instead of a benzene ring. Thiophene is a five-membered aromatic ring with a sulphur constituent.

Pharmacology

Methiopropamine functions as a selective norepinephrine-dopamine releasing agent. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects. It is approximately one third as potent as dextroamphetamine as a norepinephrine reuptake inhibitor and one fifth as much as a dopamine reuptake inhibitor. It displays negligible activity as a serotonin reuptake inhibitor.[4]

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Cognitive effects
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After effects
Aftereffects (3).svg

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational MPA use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because MPA has very little history of human usage. Anecdotal evidence from people who have tried MPA within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of MPA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of MPA develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). MPA presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of MPA all stimulants will have a reduced effect.

Psychosis

Main article: Stimulant psychosis

Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions).[5] A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely.[6][7] The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.[8]

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal issues

  • Finland - Methiopropamine is illegal in Finland.
  • Germany - Methiopropamine is illegal in Germany.
  • United Kingdom - Methiopropamine is a Class B drug.[10]
  • United States - Methiopropamine is not scheduled at the federal level in the United States,[11] but it could be considered an analogue of methamphetamine in which case purchase, sale, or possession could be prosecuted under the Federal Analogue Act. Methiopropamine's structure differs from methamphetamine's structure significantly more than previous successful prosecutions under the same law.[citation needed]
    • Florida - Methiopropamine is a Schedule I controlled substance in the state of Florida, making it illegal to buy, sell, or possess in Florida.[12]

See also

External links

References

  1. α-Thienylaminoalkanes | http://pubs.acs.org/doi/abs/10.1021/ja01255a001
  2. The syntheses of 1-(2-thienyl)-2-(methylamino) propane (methiopropamine) and its 3-thienyl isomer for use as reference standards. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/21770051
  3. https://www.ukchemicalresearch.org/Thread-MPA
  4. Neurochemical profiles of some novel psychoactive substances (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0014299912010114
  5. Treatment for amphetamine psychosis | [1]
  6. Treatment for amphetamine psychosis | [2]
  7. Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.
  8. Treatment for amphetamine psychosis | [3]
  9. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  10. United Kingdom. (2017). Misuse of Drugs Act 1971 (S.I. 2017/1114). London: The Stationery Office Limited. Retrieved February 9, 2018, from https://www.legislation.gov.uk/uksi/2017/1114/made
  11. http://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm
  12. http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html