Talk:Hydroxyzine
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| Summary sheet: Hydroxyzine |
Template:SubstanceBox/Hydroxyzine
Hydroxyzine is a antihistamine substance of the diphenylmethylpiperazine class. It is in the piperazine family of chemicals.[1] It's main mechanism of action is as a potent and selective histamine H1 receptor antagonist.[2][3]
Hydroxyzine is used in the treatment of itchiness, anxiety, and nausea due to motion sickness.[4]
Ferreri et al. (1995), in a placebo-controlled study, found hydroxyzine to be effective for the treatment of GAD (Generalized Anxiety Disorder) after 1 week of treatment and maintained the improvement throughout the study.[5]
Recreational use of hydroxyzine is inprofilable and is't associated with dependence and abuse, but with fast tolerance.
Contents
History and culture
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It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year.[6][7] In the United Kingdom 28 doses cost less than a pound.[8] In the United States the wholesale cost in 2018 was about 0.05 USD per dose.[9] In the United States about 8 million prescriptions were written for hydroxyzine in 2016.[10]
Chemistry
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This chemistry section is incomplete. You can help by adding to it. |
Hydroxyzine is a member of the diphenylmethylpiperazine class of antihistamines.
Analogues of hydroxyzine include buclizine, cetirizine, cinnarizine, cyclizine, etodroxizine, meclizine, and pipoxizine among others.
Hydroxyzine is synthesized by the alkylation of 1-(4-chlorobenzhydryl)piperazine with 2-(2-Chloroethoxy)ethanol[11]
Pharmacology
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Hydroxyzine is as a potent and selective histamine H1 receptor antagonist. This action is responsible for its antihistamine and sedative effects.[12][13] Hydroxyzine also has very low affinity for the muscarinic acetylcholine receptors, and in accordance, has low or no propensity for producing anticholinergic side effects. In addition to its antihistamine activity, hydroxyzine has also been shown to act more weakly as an antagonist of the serotonin 5-HT2A receptor, the dopamine D2 receptor, and the α1-adrenergic receptor, what causes anxiolytic.[14][15]
Subjective effects
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This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it. |
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature which relies on collected anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.
Physical effects 
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- Sedation - Hydroxyzine is reported to be weakly or moderately sedating. It can be helpfull to fall a sleep.
- Perception of bodily heaviness - Hydroxyzine makes your body heavy and unwilling to perform tasks.
- Motor control loss
Visual effects 
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Enhancements
Distortions
Geometry
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Hallucinatory states
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Cognitive effects 
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- Analysis suppression
- Anxiety suppression - The anxiolytic effect of Hydroxyzine is rather mild compared to that of benzodiazapines.
- Sleepiness
- Cognitive fatigue
- Confusion
- Creativity suppression
- Decreased libido
Auditory effects 
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Multi-sensory effects 
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Transpersonal effects 
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Experience reports
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
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This toxicity and harm potential section is a stub. As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it. |
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
Tolerance and addiction potential
Dangerous interactions
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This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. |
Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
Legal status
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See also
External links
Literature
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References
- ↑ "Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 Nov 2018.
- ↑ Szepietowski J, Weisshaar E (2016). Itin P, Jemec GB (eds.). Itch - Management in Clinical Practice. Current Problems in Dermatology. 50. Karger Medical and Scientific Publishers. pp. 1–80. ISBN 9783318058895.
- ↑ Hosák L, Hrdlička M, et al. (2017). Psychiatry and Pedopsychiatry. Charles University in Prague, Karolinum Press. p. 364. ISBN 9788024633787.
- ↑ "Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 Nov 2018.
- ↑ Rosario B. Hidalgo, David V. Sheehan, in Handbook of Clinical Neurology, 2012
- ↑ "Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 Nov 2018.
- ↑ Shorter E (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 9780195368741.
- ↑ British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.
- ↑ "NADAC as of 2018-11-21". Centers for Medicare and Medicaid Services. Retrieved 21 Nov 2018.
- ↑ British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.
- ↑ H. Morren, U.S. Patent 2,899,436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).
- ↑ Szepietowski J, Weisshaar E (2016). Itin P, Jemec GB (eds.). Itch - Management in Clinical Practice. Current Problems in Dermatology. 50. Karger Medical and Scientific Publishers. pp. 1–80. ISBN 9783318058895.
- ↑ Hosák L, Hrdlička M, et al. (2017). Psychiatry and Pedopsychiatry. Charles University in Prague, Karolinum Press. p. 364. ISBN 9788024633787.
- ↑ Snowman AM, Snyder SH (1990). "Cetirizine: actions on neurotransmitter receptors". J. Allergy Clin. Immunol. 86 (6 Pt 2): 1025–8. doi:10.1016/S0091-6749(05)80248-9. PMID 1979798.
- ↑ Szepietowski J, Weisshaar E (2016). Itin P, Jemec GB (eds.). Itch - Management in Clinical Practice. Current Problems in Dermatology. 50. Karger Medical and Scientific Publishers. pp. 1–80. ISBN 9783318058895.