Methallylescaline

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Summary sheet: Methallylescaline
Methallylescaline
Methallylescaline.svg
Chemical Nomenclature
Common names Methallylescaline, MAL
Substitutive name 4-methallyloxy-3,5-dimethoxyphenethylamine
Systematic name 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold Common Heavy
5 - 15 - 25 - 40 - 60 mg
Light Strong
Threshold 5 - 15 mg
Light 15 - 25 mg
Common 25 - 40 mg
Strong 40 - 60 mg
Heavy 60 mg +
Duration
Total 6 - 12 hours
Onset 20 - 60 minutes
Come up 30 - 90 minutes
Peak 3 - 5 hours
Offset 2 - 4 hours
After effects 4 - 8 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

4-Methallyloxy-3,5-dimethoxyphenethylamine (also known as Methallylescaline, and MAL) is a synthetic psychedelic substance of the phenethylamine chemical class. It is reported to produce hallucinogenic and stimulant effects comparable to that of other mescaline analogs (e.g. allylescaline, proscaline, and escaline) when administered.

The effects of this compound were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg orally and describes the duration of action to be 8 - 12 hours.[1]

Very little data exists about the pharmacological properties, metabolism, and toxicity of methallylescaline, and it has little history of human usage. It is advised to approach this poorly understood, long-lived psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

Chemistry

Generic structure of a phenethylamine molecule

Methallylescaline, or 4-methallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. Methallylescaline contains two methoxy functional groups (CH3O-) which are attached to carbons R3 and R5 of the phenyl ring.

Methallylescaline is substituted at R4 with a methallyloxy chain. This three carbon chain consists of a R2 methyl substituted allyl group with a double bond on the terminal carbon. This chain is connected to the phenyl ring at R4 through an ether (oxygen) bridge.

Pharmacology

Further information: Serotonergic psychedelic

Methallylescaline likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from methallylescaline's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational methallylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because methallylescaline is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried methallylescaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Methallylescaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of methallylescaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Methallylescaline presents cross-tolerance with all psychedelics, meaning that after the consumption of methallylescaline all psychedelics will have a reduced effect.

Legal issues

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[2]
  • United States - Methallylescaline is unscheduled in the U.S., but may be illegal via the Federal Analogue Act.

See also

External links

References

  1. #99 MAL: Methallylescaline; 3,5-Dimethoxy-4-methallyloxyphenethylamine (PiHKAL) | http://isomerdesign.com/PiHKAL/read.php?id=99&domain=pk |
  2. Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted