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Summary sheet: Troparil
Chemical Nomenclature
Common names Troparil, WIN 35,065-2, β-CPT
Substitutive name (−)-2β-Carbomethoxy-3β-phenyltropane
Systematic name Methyl (1R,2S,3S,5S)-3-(phenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Class Membership
Psychoactive class Stimulant
Chemical class Tropane
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 5 mg
Light 5 - 10 mg
Common 10 - 25 mg
Strong 25 - 40 mg
Heavy 40 mg +
Total 30 - 60 minutes
Onset 20 - 60 seconds
Peak 20 - 30 minutes
Offset 10 - 20 minutes

Threshold 5 mg
Light 15 - 20 mg
Common 20 - 30 mg
Strong 30 - 60 mg
Heavy 60 mg +
Total 45 - 90 minutes
Onset 5 - 10 minutes
Come up 5 - 10 minutes
Peak 20 - 40 minutes
Offset 20 - 30 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Troparil is a synthetic stimulant substance of the tropane chemical class. It is a structurally similar analog of cocaine.[1]

Being an only recently introduced research chemical, extremely little is known about the pharmacology, metabolism, and toxicity of troparil in humans. It is highly advised to use harm reduction practices if choosing to use this substance.

History and culture

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This chemistry section is incomplete.

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Troparil primarily acts as a dopamine reuptake inhibitor (DRI). While this effect is a few times more potent as with cocaine, the effect of troparil on serotonin reuptake inhibition is slightly less pronounced.

Transporter binding profiles of tropane stimulants[2][3]
IC50 (nM)
Cocaine 89 ± 4.8 3298 ± 293 1045 ± 89
Dichloropane 0.79 ± 0.09 17.96 ± 0.85 3.13 ± 0.36
Troparil 23 ± 5 920 ± 73 1962 ± 61

Subjective effects

Effects of troparil are thought to be similar to cocaine, albeit longer lasting.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

After effects
Aftereffects (3).svg

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational troparil use has not been studied in any scientific context and the exact toxic dosage is unknown. This is because troparil has very little history of human usage.

There is no research demonstrating so, but due to the lack of an ester linkage, troparil might possibly be slightly less cardiotoxic than cocaine.[citation needed] Nevertheless, it still poses a risk to the cardiovascular system and should not be used with a pre-existing heart condition.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions


This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

External links



  1. Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. |
  2. Carroll, F. I., Kotian, P., Dehghani, A., Gray, J. L., Kuzemko, M. A., Parham, K. A., Abraham, P., Lewin, A. H., Boja, J. W., Kuhar, M. J. (January 1995). "Cocaine and 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Ester and Amide Analogs. New High-Affinity and Selective Compounds for the Dopamine Transporter". Journal of Medicinal Chemistry. 38 (2): 379–388. doi:10.1021/jm00002a020. ISSN 0022-2623. 
  3. Carroll, F. I., Blough, B. E., Nie, Z., Kuhar, M. J., Howell, L. L., Navarro, H. A. (1 April 2005). "Synthesis and Monoamine Transporter Binding Properties of 3β-(3',4'-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters". Journal of Medicinal Chemistry. 48 (8): 2767–2771. doi:10.1021/jm040185a. ISSN 0022-2623.