Talk:Troparil

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Summary sheet: Troparil

Chemical Nomenclature

Common names

Troparil, WIN 35,065-2, β-CPT

Substitutive name

(−)-2β-Carbomethoxy-3β-phenyltropane

Systematic name

Methyl (1R,2S,3S,5S)-3-(phenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Class Membership

Psychoactive class

Stimulant

Chemical class

Tropane

Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Smoked
Dosage
Threshold	5 mg
Light	5 - 10 mg
Common	10 - 25 mg
Strong	25 - 40 mg
Heavy	40 mg +
Duration
Total	30 - 60 minutes
Onset	20 - 60 seconds
Peak	20 - 30 minutes
Offset	10 - 20 minutes

⇣ Insufflated
Dosage
Threshold	5 mg
Light	15 - 20 mg
Common	20 - 30 mg
Strong	30 - 60 mg
Heavy	60 mg +
Duration
Total	45 - 90 minutes
Onset	5 - 10 minutes
Come up	5 - 10 minutes
Peak	20 - 40 minutes
Offset	20 - 30 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions

Troparil is a synthetic stimulant substance of the tropane chemical class. It is a structurally similar analog of cocaine.^[1]

Being an only recently introduced research chemical, extremely little is known about the pharmacology, metabolism, and toxicity of troparil in humans. It is highly advised to use harm reduction practices if choosing to use this substance.

History and culture

This History and culture section is a stub.

As a result, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

This chemistry section is incomplete.

You can help by adding to it.

Pharmacology

Troparil primarily acts as a dopamine reuptake inhibitor (DRI). While this effect is a few times more potent as with cocaine, the effect of troparil on serotonin reuptake inhibition is slightly less pronounced.

Transporter binding profiles of tropane stimulants^[2]^[3]
	IC₅₀ (nM)
Compound	DAT	NET	SERT
Cocaine	89 ± 4.8	3298 ± 293	1045 ± 89
Dichloropane	0.79 ± 0.09	17.96 ± 0.85	3.13 ± 0.36
Troparil	23 ± 5	920 ± 73	1962 ± 61

Subjective effects

Effects of troparil are thought to be similar to cocaine, albeit longer lasting.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

- Increased heart rate
- Stimulation
- Abnormal heartbeat - This substance consistently raises one's heart rate to abnormally high levels which can be potentially dangerous with prolonged or extremely high dosages.
- Appetite suppression
- Bodily control enhancement
- Bronchodilation
- Dehydration
- Increased bodily temperature
- Increased blood pressure
- Increased perspiration
- Pain relief
- Physical euphoria
- Teeth grinding
- Temporary erectile dysfunction
- Vasoconstriction

Cognitive effects

- Analysis enhancement
- Anxiety suppression
- Compulsive redosing
- Cognitive euphoria
- Disinhibition
- Ego inflation
- Focus enhancement
- Increased libido
- Increased music appreciation
- Motivation enhancement
- Thought acceleration
- Thought organization
- Wakefulness

After effects

The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion.
- Anxiety
- Cognitive fatigue
- Depression
- Irritability
- Motivation suppression
- Thought deceleration
- Wakefulness

Toxicity and harm potential

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational troparil use has not been studied in any scientific context and the exact toxic dosage is unknown. This is because troparil has very little history of human usage.

There is no research demonstrating so, but due to the lack of an ester linkage, troparil might possibly be slightly less cardiotoxic than cocaine.^{[citation needed]} Nevertheless, it still poses a risk to the cardiovascular system and should not be used with a pre-existing heart condition.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

External links

Literature

References

↑ Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. | http://pubs.acs.org/doi/abs/10.1021/jm020410t
↑ Carroll, F. I., Kotian, P., Dehghani, A., Gray, J. L., Kuzemko, M. A., Parham, K. A., Abraham, P., Lewin, A. H., Boja, J. W., Kuhar, M. J. (January 1995). "Cocaine and 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Ester and Amide Analogs. New High-Affinity and Selective Compounds for the Dopamine Transporter". Journal of Medicinal Chemistry. 38 (2): 379–388. doi:10.1021/jm00002a020. ISSN 0022-2623.
↑ Carroll, F. I., Blough, B. E., Nie, Z., Kuhar, M. J., Howell, L. L., Navarro, H. A. (1 April 2005). "Synthesis and Monoamine Transporter Binding Properties of 3β-(3',4'-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters". Journal of Medicinal Chemistry. 48 (8): 2767–2771. doi:10.1021/jm040185a. ISSN 0022-2623.

[1] Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. | http://pubs.acs.org/doi/abs/10.1021/jm020410t

[2] Carroll, F. I., Kotian, P., Dehghani, A., Gray, J. L., Kuzemko, M. A., Parham, K. A., Abraham, P., Lewin, A. H., Boja, J. W., Kuhar, M. J. (January 1995). "Cocaine and 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Ester and Amide Analogs. New High-Affinity and Selective Compounds for the Dopamine Transporter". Journal of Medicinal Chemistry. 38 (2): 379–388. doi:10.1021/jm00002a020. ISSN 0022-2623.

[3] Carroll, F. I., Blough, B. E., Nie, Z., Kuhar, M. J., Howell, L. L., Navarro, H. A. (1 April 2005). "Synthesis and Monoamine Transporter Binding Properties of 3β-(3',4'-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters". Journal of Medicinal Chemistry. 48 (8): 2767–2771. doi:10.1021/jm040185a. ISSN 0022-2623.

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