Talk:Troparil

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Summary sheet: Troparil
Troparil
Troparil.svg
Chemical Nomenclature
Common names Troparil, WIN 35,065-2, β-CPT
Substitutive name (−)-2β-Carbomethoxy-3β-phenyltropane
Systematic name Methyl (1R,2S,3S,5S)-3-(phenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Class Membership
Psychoactive class Stimulant
Chemical class Tropane
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold 5 mg
Light 5 - 10 mg
Common 10 - 25 mg
Strong 25 - 40 mg
Heavy 40 mg +
Duration
Total 30 - 60 minutes
Onset 20 - 60 seconds
Peak 20 - 30 minutes
Offset 10 - 20 minutes




Insufflated
Dosage
Threshold 5 - 15 mg
Light 15 - 20 mg
Common 20 - 30 mg
Strong 30 - 60 mg
Heavy 60 mg +
Duration
Total 45 - 90 minutes
Onset 5 - 10 minutes
Come up 5 - 10 minutes
Peak 20 - 40 minutes
Offset 20 - 30 minutes






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Troparil is a synthetic stimulant substance of the tropane chemical class. It is a structurally similar analog of cocaine.[1]

Being an only recently introduced research chemical, extremely little is known about the pharmacology, metabolism, and toxicity of troparil in humans. It is highly advised to use harm reduction practices if choosing to use this substance.

History and culture

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Chemistry

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Pharmacology

Troparil primarily acts as a dopamine reuptake inhibitor (DRI). While this effect is a few times more potent as with cocaine, the effect of troparil on serotonin reuptake inhibition is slightly less pronounced.

Transporter binding profiles of tropane stimulants[2][3]
IC50 (nM)
Compound DAT NET SERT
Cocaine 89 ± 4.8 3298 ± 293 1045 ± 89
Dichloropane 0.79 ± 0.09 17.96 ± 0.85 3.13 ± 0.36
Troparil 23 ± 5 920 ± 73 1962 ± 61

Subjective effects

Effects of troparil are thought to be similar to cocaine, albeit longer lasting.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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After effects
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Toxicity and harm potential

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We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational troparil use has not been studied in any scientific context and the exact toxic dosage is unknown. This is because troparil has very little history of human usage.

There is no research demonstrating so, but due to the lack of an ester linkage, troparil might possibly be slightly less cardiotoxic than cocaine.[citation needed] Nevertheless, it still poses a risk to the cardiovascular system and should not be used with a pre-existing heart condition.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

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Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume.

Legal status

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See also

External links

Literature

References

  1. Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors. | http://pubs.acs.org/doi/abs/10.1021/jm020410t
  2. Cocaine and 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Ester and Amide Analogs. New High-Affinity and Selective Compounds for the Dopamine Transporter | http://pubs.acs.org/doi/abs/10.1021/jm00002a020
  3. Synthesis and Monoamine Transporter Binding Properties of 3β-(3‘,4‘-Disubstituted phenyl)tropane-2β-carboxylic Acid Methyl Esters | http://pubs.acs.org/doi/abs/10.1021/jm040185a