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|Summary sheet: Methcathinone|
|Common names||Methcathinone, Ephedrone, Methcat, Cat, Jeff, MC|
|Psychoactive class||Stimulant, Entactogen|
|Routes of Administration|
Methcathinone (also known as Ephedrone, Methcat, CAT) is a synthetic stimulant substance of the cathinone chemical class. It produces standard amphetamine-like stimulant effects. It is similar to the cathinone compounds found in the khat plant of eastern Africa and mephedrone in its structure and effects.
Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known mephedrone or synthesized from OTC drugs containing ephedrine or pseudoephedrine.
Methcathinone is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain containing a beta-ketone group (what is known as a cathinone molecule) with an additional methyl substitution at Rα. It can be thought of as the cathinone homolog of methamphetamine as it has the same general formula, differing only in the addition of a single double bonded oxygen.
Although the effects of methcathinone have not been formally studied on the same level as amphetamines, it is possible to speculate that like other simple substituted cathinone, it most likely acts primarily as a dopamine and norepinephrine reuptake inhibitor. The result of this is an effective increase in the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the key area of the brain linked to reward and pleasure to extra-endogenous levels, resulting in stimulating, motivatory and euphoric effects.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Increased heart rate
- Increased perspiration
- Increased blood pressure
- Muscle contractions
- Muscle spasms
- Physical euphoria
- Spontaneous physical sensations
- Stomach cramps
- Tactile enhancement
- Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.
The cognitive effects of methcathinone can be broken down into several components which progressively intensify proportional to dosage.
The most prominent of these cognitive effects generally include:
- Analysis enhancement
- Cognitive euphoria
- Compulsive redosing
- Empathy, love, and sociability enhancement - This particular effect, although distinct, is far less prominent than the same effect found within traditional entactogens such as MDMA or 2C-B.
- Focus enhancement
- Increased libido or Decreased libido
- Increased music appreciation
- Memory enhancement
- Motivation enhancement
- Thought acceleration
- Thought organization
- Time distortion
- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
Anecdotal reports which describe the effects of this compound within our experience index include:
- Responsible use
- 3-MMC (3-methylmethcathinone)
- Cathinone derivatives: A review of their chemistry, pharmacology and toxicology | DOI 10.1002/dta.31