Talk:Methcathinone

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Summary sheet: Methcathinone
Methcathinone
Methcathinone.svg
Chemical Nomenclature
Common names Methcathinone, Ephedrone, Methcat, Cat, Jeff, MC
Substitutive name α-methylamino-propiophenone
Systematic name (RS)-2-(methylamino)-1-phenyl-propan-1-one
Class Membership
Psychoactive class Stimulant, Entactogen
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 25 - 50 mg
Light 50 - 100 mg
Common 100 - 200 mg
Strong 200 - 300 mg
Heavy 300 mg +
Duration
Total 4 - 6 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Methcathinone (also known as Ephedrone, Methcat, CAT) is a synthetic stimulant substance of the cathinone chemical class. It produces standard amphetamine-like stimulant effects. It is similar to the cathinone compounds found in the khat plant of eastern Africa and mephedrone in its structure and effects.

Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known mephedrone or synthesized from OTC drugs containing ephedrine or pseudoephedrine.

Chemistry

Methcathinone is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain containing a beta-ketone group (what is known as a cathinone molecule) with an additional methyl substitution at Rα. It can be thought of as the cathinone homolog of methamphetamine as it has the same general formula, differing only in the addition of a single double bonded oxygen.

Pharmacology

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Although the effects of methcathinone have not been formally studied on the same level as amphetamines, it is possible to speculate that like other simple substituted cathinone, it most likely acts primarily as a dopamine and norepinephrine reuptake inhibitor.[1] The result of this is an effective increase in the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the key area of the brain linked to reward and pleasure to extra-endogenous levels, resulting in stimulating, motivatory and euphoric effects.

Subjective effects

The effects listed below are based on the subjective effect index, which is based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will rarely (if ever) occur all at once but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Cognitive effects
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After effects
Aftereffects (3).svg


Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

See also

External links

References

  1. Cathinone derivatives: A review of their chemistry, pharmacology and toxicology | DOI 10.1002/dta.31