Project talk:Methcathinone

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Summary sheet: Methcathinone
Methcathinone
DMT.svg
Chemical Nomenclature
Common names DMT, Dimethyltryptamine, Dmitri
Substitutive name N,N-Dimethyltryptamine
Systematic name 2-(1H-Indol-3-yl)-N,N-dimethylethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability x% - y%[1]
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total x - y hours
Onset x - y minutes
Come up x - y minutes
Peak x - y hours
Offset x - y hours
After effects x - y hours


Sublingual
Dosage
Bioavailability x% - y%
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total a - b hours
Onset a - b minutes
Come up a - b minutes
Peak a - b hours
Offset a - b hours
After effects a - b hours







DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions


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History and culture

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Chemistry

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Pharmacology

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Subjective effects

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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Visual effects
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Cognitive effects
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Auditory effects
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Multi-sensory effects
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Transpersonal effects
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Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

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Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

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Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

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See also

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Literature

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References

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This page has not been fully approved by the PsychonautWiki administrators.

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Template:Joey from bluelight.org

The best defintion to edit on is NOT a single sentence about some nonsense about not dying. Might not die if the best info is back on. (Joey from bluelight.org)

Summary sheet: Methcathinone
Methcathinone
Methcathinone.svg
Chemical Nomenclature
Common names Methcathinone, Ephedrone, Methcat, Cat, Jeff, MC
Substitutive name α-methylamino-propiophenone
Systematic name (RS)-2-(methylamino)-1-phenyl-propan-1-one
Class Membership
Psychoactive class Stimulant / Entactogen
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 25 mg
Light 50 - 100 mg
Common 100 - 200 mg
Strong 200 - 300 mg
Heavy 300 mg +
Duration
Total 4 - 6 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions


Methcathinone (also known as Ephedrone originally, Methcat and CAT) is a synthetic stimulant substance of the cathinone chemical class. It produces standard amphetamine-like stimulant effects. It is similar to the cathinone compounds found in the khat plant of eastern Africa and mephedrone in its structure and effects.

Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known mephedrone or synthesized from OTC drugs containing ephedrine or pseudoephedrine.

Chemistry

Methcathinone is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain containing a beta-ketone group (what is known as a cathinone molecule) with an additional methyl substitution at Rα. It can be thought of as the cathinone homolog of methamphetamine as it has the same general formula, differing only in the addition of a single double bonded oxygen.

Pharmacology

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Although the effects of methcathinone have not been formally studied on the same level as amphetamines, it is possible to speculate that like other simple substituted cathinone, it most likely acts primarily as a dopamine and norepinephrine reuptake inhibitor.[1] The result of this is an effective increase in the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the key area of the brain linked to reward and pleasure to extra-endogenous levels, resulting in stimulating, motivatory and euphoric effects.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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Cognitive effects
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After effects
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How to Dose Properly

Methcathinone, due to its nature, can often cause extreme compulsive redosing. A good strategy is to pre-plan your experience in advance. To minimalize the risk of compulsive redosing and severe negative effects, follow the below points: ▹Pre-plan the total amount of Methcathinone you will take. Limit the amount you have accessible to that amount. ▹Make a rough timeline of the experience. Plan how many re-doses you will do and when you will re-dose.


I have discovered a few ways you can use Methcathinone.

①Take a strong or heavy dose and redose twice. This is done by taking a first dose of 250-500mg (T:00:00) Afterwards you take the a redose, which is 40-50% the amount of the first dose (T:00:30-005:0) Which is then followed by a final re-dose, which is 40-50% of the first dose (T:01:15-01:45).

②Take multiple common doses. Take 150-200mg, then redose when it wears off with the same dose. Do a maximum of four doses.


0When you take a dosage of Methcathinone, per say 350mg, you have to redose 25 mins later as a 40-50% of the first dose. So you don't comedown.

Its really worth to redose once since actually it will be only a 45 min ride and the 4 hours comedown hell. Gradually decreasing the dose instead aka a redose will make it a ton more manageable. You can then redose another 40% or leave it. But don't redose more than twice.0

0What I recommend for the comedown is that 60mins after you redosed last to take 20% of the first dose. Then to stop. That's the best method to not have a huge comedown.0

0For a mild stimulating experience, take a light dose first, then redose with a medium dose, then as a final, a medium or medium-high dose. Space the doses out more.0

Synthesis

Methcathinone is synthesised most easily by reacting Pseudoephedrine with KMnO4. The reaction is very specific though. A very specific temperature needs to be achieved, below zero, so that the oxidation is subtle and not too energetic, so that it does not destroy the Pseudoephedrine and make it into Benzaldehyde. The same goes for the amount of KMnO4, it has to be a specific ratio of oxidizer to Pseudoephedrine.

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See also


Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:



External links

References

  1. Cathinone derivatives: A review of their chemistry, pharmacology and toxicology | DOI 10.1002/dta.31

https://bluelight.org/xf/members/joey.390415/

https://bluelight.org/xf/threads/what-was-the-first-research-chemical-that-you-tried-and-when.908924/post-15617257