From PsychonautWiki
(Redirected from Fluorophenibut)
Jump to navigation Jump to search
Summary sheet: F-Phenibut
Chemical Nomenclature
Common names F-Phenibut, Fluorophenibut, Fluorobut
Substitutive name β-(4-flourophenyl)-GABA
Systematic name 5-amino-4-(4-fluorophenyl)-1-hydroxypentan-2-one
Class Membership
Psychoactive class Depressant
Chemical class Gabapentinoid
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 50 mg
Light 100 - 150 mg
Common 150 - 400 mg
Strong 400 - 600 mg
Heavy 600 mg +
Total 6 - 8 hours
Onset 20 - 60 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


F-Phenibut (also known as 4-Fluorophenibut, Fluorophenibut, Fluorobut, Baflofen and CGP-11130) is a central nervous system depressant and closely related structural analog of phenibut. F-Phenibut possesses an effect profile similar to phenibut but with a faster onset, significantly increased potency, and shorter total duration.[citation needed] It has recently become available through online research chemical vendors, although little is known about this substance, particularly its potential toxicity and addiction potential.

The substance can be classified as a gabapentinoid, a class which contains other substances such as gabapentin, pregabalin[1], baclofen, and GABOB.[2][3] It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA), with an addition of a phenyl ring that allows it to cross the blood–brain barrier.[2]


As with phenibut, F-Phenibut is a derivative of GABA, except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers.[4] It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group).[5] Additionally, the widely prescribed gabapentinoid pregabalin also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group in the S configuration. F-Phenibut is water soluble.


F-phenibut acts as a potent agonist of the GABA-B receptor and in this regard is more similar to baclofen than phenibut.[6]

It is also possible that F-Phenibut binds to the α2δ-1 site of voltage-gated calcium channels in a manner similar to that of other gabapentinoids. By binding to this site, F-Phenibut may reduce the release of several excitatory neurotransmitters, including glutamate, substance P, acetylcholine, and norepinephrine. This, in turn, increases GABAergic activity.[citation needed] As the GABA system is the most prevalent inhibitory receptor set within the brain[citation needed], its modulation may be responsible for the relaxing, sedating, and calming effects of F-Phenibut on the central nervous system.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In comparison to regular phenibut, this compound has a significantly faster onset, a shorter duration, and slightly less stimulation. Early reports suggest that in comparison to other commonly used GABAgenic depressants such as alcohol or benzodiazepines, this compound produces less inebriation and more euphoria, giving it more recreational potential as well as a correspondingly higher risk of abuse.

Physical effects

Cognitive effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

F-Phenibut likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol, benzodiazepines or opioids.

The toxicity and long-term health effects of recreational F-Phenibut use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because F-Phenibut has very little history of human usage. Anecdotal evidence from people who have tried this substance within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

F-Phenibut is moderately physically and psychologically addictive, although this usually only occurs with heavy abuse of the substance. This is likely even more so than its predecessor phenibut since its more rapid onset allows more convenient compulsive redosing.

Tolerance will develop to the sedative-hypnotic effects within a couple of days of continuous use. After cessation, the tolerance returns to baseline in 7 - 14 days. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing and may necessitate a gradual dose reduction.

Withdrawal symptoms likely include severe anxiety, nervousness, hallucinations, tremors, agitation, dizziness, tension, irritation, rapid heartbeat, fatigue, loss of appetite, nausea, vomiting, psychosis, and insomnia in a similar manner to phenibut.[7]

F-Phenibut presents cross-tolerance with all GABAgenic depressants, meaning that after its consumption most depressants will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • Depressants (1,4-Butanediol, 2M2B, alcohol, benzodiazepines, barbiturates, GHB/GBL, methaqualone, opioids) - This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit while unconscious. If nausea or vomiting occurs before a loss of consciousness, users should attempt to fall asleep in the recovery position or have a friend move them into it.
  • Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the recovery position or have a friend move them into it.
  • Stimulants - Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

Legal issues


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Germany: F-Phenibut is not a controlled substance under the BtMG.[8] It is legal, as long as it is not sold for human consumption, according to §2 AMG.[9]
  • Switzerland: F-Phenibut is not controlled under Buchstabe A, B, C and D. It could be considered legal.[10]
  • United Kingdom: It may be illegal to produce, supply, or import this substance under the Psychoactive Substance Act 2016, which blanketly applies the aforementioned restrictions on all "psychoactive substances" with exemptions for alcohol, nicotine and "medicinal products."[11]

See also

External links


  1. Wyllie, E., Cascino, G. D., Gidal, B. E., Goodkin, H. P. (17 February 2012). Wyllie’s Treatment of Epilepsy: Principles and Practice. Lippincott Williams & Wilkins. ISBN 9781451153484. 
  2. 2.0 2.1 Lapin, I. (7 June 2006). "Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug". CNS Drug Reviews. 7 (4): 471–481. doi:10.1111/j.1527-3458.2001.tb00211.x. ISSN 1080-563X. 
  3. Benzon, H., Rathmell, J. P., Wu, C. L., Turk, D., Argoff, C. E., Hurley, R. W. (11 September 2013). Practical Management of Pain E-Book. Elsevier Health Sciences. ISBN 9780323170802. 
  4. Dambrova, M., Zvejniece, L., Liepinsh, E., Cirule, H., Zharkova, O., Veinberg, G., Kalvinsh, I. (31 March 2008). "Comparative pharmacological activity of optical isomers of phenibut". European Journal of Pharmacology. 583 (1): 128–134. doi:10.1016/j.ejphar.2008.01.015. ISSN 0014-2999. 
  5. Shulgina, G. I. (December 1986). "On neurotransmitter mechanisms of reinforcement and internal inhibition". The Pavlovian Journal of Biological Science. 21 (4): 129–140. doi:10.1007/BF02734511. ISSN 0093-2213. 
  6. Irie, T., Yamazaki, D., Kikura-Hanajiri, R. (5 October 2020). "F-phenibut (β-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells". European Journal of Pharmacology. 884: 173437. doi:10.1016/j.ejphar.2020.173437. ISSN 0014-2999. 
  7. Group, D. W. (25 February 2015). Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances, 2d ed. McFarland. ISBN 9780786441426. 
  8. Anlage I BtMG - Einzelnorm 
  9. § 2 AMG - Einzelnorm 
  10. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  11. Psychoactive Substances Act 2016