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An anxiolytic (also antipanic or antianxiety agent) is a substance or pharmaceutical that inhibits anxiety. These substances include agents such as opioids, benzodiazepines, serotonergic substances, and MAOIs. These agents contrast to anxiogenics, which increase anxiety. Examples of anxiogenics include agents such as Ro5-4864 (4'-chlorodiazepam), which also acts as a convulsant.[1][2][3] 4'-chlorodiazepam is not to be confused with diclazepam (2'-chlorodiazepam). Most stimulants are also anxiogenic in nature. (Note: talk pages (such as Talk:Sertraline) are not complete and may not be approved by PsychonautWiki staff.)


  1. File, S. E., & Lister, R. G. (1983). The anxiogenic action of Ro 5-4864 is reversed by phenytoin. Neuroscience letters, 35(1), 93-96.
  2. Pellow, S., & File, S. E. (1984). Behavioural actions of Ro 5-4864: a peripheral-type benzodiazepine?. Life sciences, 35(3), 229-240.
  3. Weissman, B. A., Cott, J., Hommer, D., Quirion, R., Paul, S., & Skolnick, P. (1982). Pharmacological, electrophysiological, and neurochemical actions of the convulsant benzodiazepine Ro 5-4864 (4'-chlordiazepam). Advances in biochemical psychopharmacology, 38, 139-151.