|Summary sheet: F-Phenibut|
|Common names||F-Phenibut, Fluorophenibut, Fluorobut|
|Routes of Administration|
F-Phenibut (also known as 4-Fluorophenibut, Fluorophenibut, Fluorobut and CGP-11130) is a central nervous system depressant and closely related structural analog of phenibut. F-Phenibut possesses an effect profile similar to phenibut but with a faster onset, significantly increased potency, and shorter total duration. It has recently become available through online research chemical vendors, although little is known about this substance, particularly its potential toxicity and addiction potential.
The substance can be classified as a gabapentinoid, a class which contains other substances such as gabapentin, pregabalin , baclofen, and GABOB. It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA), with an addition of a phenyl ring that allows it to cross the blood–brain barrier.
As with phenibut, F-Phenibut is a derivative of GABA, except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers. It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group). Additionally, the widely prescribed gabapentinoid pregabalin also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group.
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely speculation based upon its structural and subjective effect similarities to other depressants or gabapentinoid such as phenibut, gabapentin, and pregabalin.
Among other things, it is likely that this compound exerts its effects by binding to the α2δ-1 site of voltage-gated calcium channels in a manner which is similar to that of other gabapentinoids. By binding to this site, F-Phenibut may reduce the release of several excitatory neurotransmitters, including glutamate, substance P, acetylcholine, and norepinephrine. This, in turn, increases GABAergic activity. As the GABA system is the most prevalent inhibitory receptor set within the brain, its modulation may be responsible for the relaxing, sedating, and calming effects of F-Phenibut on the central nervous system.
Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
In comparison to regular phenibut, this compound has a significantly faster onset, a shorter duration, and slightly less stimulation. Early reports suggest that in comparison to other commonly used GABAgenic depressants such as alcohol or benzodiazepines, this compound produces less inebriation and more euphoria, giving it more recreational potential as well as a correspondingly higher risk of abuse.
- Stimulation and Sedation - At lower doses, F-Phenibut has a mild physical and mental stimulation effect, encouraging movement, wakefulness, productivity and socialization. At higher doses, however, it becomes physically sedating, encouraging sleep and lethargy. Sleeping after dosing a small amount may result in a deep, restful sleep which can leave the user feeling refreshed and alert upon waking.
- Physical euphoria
- Respiratory depression
- Nausea - F-Phenibut can induce mild to extreme nausea depending greatly on dose and tolerance. It usually manifests roughly 90 minutes after the initial dose and generally involves waves of nausea accompanied by excessive sweating and vomiting.
- Motor control loss
- Stomach cramps
- Increased perspiration
- Dehydration - Dehydration is typically reported to occur from regular multiday usage or excessive doses; however, it can also be present even in average doses of the substance (although perhaps to a lesser degree than phenibut).
- Temperature regulation loss
- Headaches - Moderate to high doses have been reported to be a induce a mild to strong headache, typically many hours after dosing or during the comedown period.
- Muscle cramps - Muscle cramps and joint pain are sometimes accompanied at high doses.
- Frequent urination
- Appetite enhancement
- Empathy, love, and sociability enhancement - Unlike alcohol which merely increases sociability through disinhibition, F-Phenibut presents entactogenic effects which, although much weaker than that of traditional entactogens such as MDMA, are still prominent and well-defined even at moderate doses.
- Compulsive redosing - This component is highly pronounced in comparison to phenibut.
- analysis suppression - High doses will usually induce a state of mild stupor and confusion.
- Thought deceleration
- Cognitive euphoria
- Motivation enhancement
- Anxiety suppression
- Depression - A low mood can be experienced as an after effect of high or frequent dosing.
- Amnesia - In comparison to many other GABAergics, this component is very weak except at very high doses.
- Increased music appreciation
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational F-Phenibut use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because F-Phenibut has very little history of human usage. Anecdotal evidence from people who have tried this substance within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
F-Phenibut is moderately physically and psychologically addictive, although this usually only occurs with heavy abuse of the substance. This is likely even more so than its predecessor phenibut since its more rapid onset allows more convenient compulsive redosing.
Tolerance will develop to the sedative-hypnotic effects within a couple of days of continuous use. After cessation, the tolerance returns to baseline in 7 - 14 days. Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing and may necessitate a gradual dose reduction.
Withdrawal symptoms likely include severe anxiety, nervousness, hallucinations, tremors, agitation, dizziness, tension, irritation, rapid heartbeat, fatigue, loss of appetite, nausea, vomiting, psychosis, and insomnia in a similar manner to phenibut.
F-Phenibut presents cross-tolerance with all GABAgenic depressants, meaning that after its consumption most depressants will have a reduced effect.
Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
- Depressants (1,4-Butanediol, 2M2B, alcohol, benzodiazepines, barbiturates, GHB/GBL, methaqualone, opioids) - This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit while unconscious. If nausea or vomiting occurs before a loss of consciousness, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Stimulants - It can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.
- Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the recovery position or have a friend move them into it.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
- Germany: F-Phenibut is not a controlled substance under the BtMG. It is legal, as long as it is not sold for human consumption, according to §2 AMG.
- United Kingdom: It may be illegal to produce, supply, or import this substance under the Psychoactive Substance Act 2016, which blanketly applies the aforementioned restrictions on all "psychoactive substances" with exemptions for alcohol, nicotine and "medicinal products."
- "Wyllie's Treatment of Epilepsy: Principles and Practice" | https://books.google.co.uk/books?id=j9t6Qg0kkuUC&pg=RA1-PA423&redir_esc=y#v=onepage&q&f=false
- Lapin, I. (2001). "Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug" (pdf). CNS Drug Reviews | https://doi.org/10.1111/j.1527-3458.2001.tb00211.x
- "Practical Management of Pain. Elsevier Health Sciences" | https://books.google.co.uk/books?id=kfcDAQAAQBAJ&pg=PA1006&redir_esc=y#v=onepage&q&f=false
- "Comparative pharmacological activity of optical isomers of phenibut." | https://www.ncbi.nlm.nih.gov/pubmed/18275958
- On neurotransmitter mechanisms of reinforcement and internal inhibition. | https://www.ncbi.nlm.nih.gov/pubmed/2431377
- David W. Group (25 February 2015). Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances, 2d ed. McFarland. pp. 186–. | https://books.google.co.uk/books?id=ZYqoBgAAQBAJ&pg=PA186&hl=en#v=onepage&q&f=false
- Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted