5-MeO-DMT

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5-MeO-DMT is not a substitute, replacement or alternative to DMT.

Despite what their names might suggest, 5-MeO-DMT and DMT possess substantially different effect and toxicity profiles – with some evidence to suggest that 5-MeO-DMT is considerably less safe.[citation needed] They should therefore be regarded as entirely separate entities. Please see this this section for more information.

Summary sheet: 5-MeO-DMT
5-MeO-DMT
Molecular structure of 5-MeO-DMT
5-MeO-DMT.svg
Chemical Nomenclature
Common names 5-MeO-DMT, "The Power"
Substitutive name 5-Methoxy-N,N-dimethyltryptamine
Systematic name 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold 1 - 3 mg
Light 3 - 6 mg
Common 6 - 12 mg
Strong 12 - 20 mg
Heavy 20 mg +
Duration
Total 20 - 40 minutes
Onset 5 - 60 seconds
Come up 30 - 60 seconds
Peak 5 - 15 minutes
Offset 10 - 20 minutes
After effects 15 - 60 minutes




Insufflated
Dosage
Threshold 3 - 5 mg
Light 5 - 8 mg
Common 8 - 15 mg
Strong 15 - 25 mg
Heavy 25mg+
Duration
Total 2 - 3 hours
Onset 1 - 10 minutes
Peak 10 - 40 minutes
Offset 30 - 60 minutes
After effects 1 - 3 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

5-Methoxy-N,N-dimethyltryptamine (commonly known as 5-MeO-DMT, or more obscurely, The Power) is a naturally occurring psychedelic substance of the tryptamine chemical class that has been noted for the extremely powerful and short-lived entheogenic effects it produces when administered. As with its structural relatives DMT and 5-HO-DMT (Bufotenin), 5-MeO-DMT has been used as an entheogen by South American shamans for thousands of years.[1]

It is distributed in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). It has also been shown to be produced endogenously in the human body in trace amounts, although its biological function is unclear.[2]

In modern times, 5-MeO-DMT is primarily acquired and consumed in its synthetic powder form through the use of online research chemical vendors. When taken in its synthetic powder form, 5-MeO-DMT is typically vaporized, but can also be insufflated (although this is discouraged), and is active at a dose of as little as 2 mg. It has been suggested that it possesses roughly 4-5x the potency of DMT.[3]

As with DMT, 5-MeO-DMT has been demonstrated to be active orally when taken with an MAOI, but according to numerous reports this combination tends to be extremely unpleasant, producing a strong "body load" in addition to the risk of hypertensive symptoms and serotonin syndrome, and is therefore strongly advised against.[4] On both physical and psychological levels, it is considered to be substantially less safe than DMT.[citation needed]

The majority of anecdotal reports on the effects produced by this substance indicate that it is likely overly intense for those who are not already extensively experienced with hallucinogens, specifically powerful psychedelic tryptamines like DMT, ayahuasca and DPT. Therefore it is highly advised to approach this very unpredictable, and powerful hallucinogenic substance with the proper amount of precaution, preparation, and harm reduction practices if one chooses to use it.

History and culture

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This History and Culture section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

Generic structure of a tryptamine molecule.

5-MeO-DMT or 5-methoxy-N,N-dimethyltryptamine is a ring-substituted indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. 5-MeO-DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT and 5-MeO-DiPT, although it radically differs in its effects.[5]

Pharmacology

Further information: Serotonergic psychedelic

5-Meo-DMT's psychedelic effects are primarily believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Specifically, this molecule shows high binding affinity for the 5-HT2A and 5-HT1A subtypes.[6] However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be involved to an extent.[7] This can result in 5-MeO-DMT becoming dangerously toxic when combined with MAOIs, RIMAs, SSRIs, stimulants or any substance which acts as a releasing agent or reuptake inhibitor of monoamine neurotransmitters.

5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenin.[8]

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects
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Visual effects
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Transpersonal effects
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Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Natural sources

Colorado River toad

Status iucn3.1 LC.svg.png

The Colorado River toad (Incilius alvarius), also known as the Sonoran Desert toad, is a psychoactive toad found in northern Mexico and the southwestern United States. Its skin and venom contain 5-MeO-DMT and bufotenin.

The toad's primary defense system are glands that produce a poison that may be potent enough to kill a grown dog.[9] These parotoid glands also produce the 5-MeO-DMT[10] and bufotenin for which the toad is known. Fresh venom can easily be collected from these glands without harm to the toad. To do this, obtain a flat glass plate or any other smooth, nonporous surface of at least 12-inches square and hold the toad in front of the plate (which is fixed in a vertical position). When the desert toad is stroked near the parotid glands in the neck region, there is a squirting out of this venom. When it is allowed to dry on a hard surface it takes on the texture of rubber cement. It contains up to 15% 5-MeO-DMT, as well as 5-MeO-NMT and bufotenin, which have their own entries. In this manner, the venom can be collected on the glass plate, free of dirt and liquid released when the toad is handled.

Dosage

If it is assumed that an average of at least 10% of the venom is 5-MeO-DMT:

  • Threshold: 10 - 20 mg
  • Light: 20 - 50 mg
  • Common: 50 - 100 mg
  • Strong: 100 - 200 mg

If it is assumed that an average of at least 25% of the venom is 5-MeO-DMT:

  • Threshold: 4 - 8 mg
  • Light: 8 - 20 mg
  • Common: 20 - 40 mg
  • Strong: 40 - 80 mg

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational 5-MeO-DMT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 5-MeO-DMT has very little documented history of human usage. Anecdotal reports from people within the community who have tried 5-MeO-DMT suggests that there are unlikely to be any negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

5-MeO-DMT is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 5-MeO-DMT are built almost immediately after ingestion. After that, it takes about 1 hour for the tolerance to be reduced to half and 2 hours to be back at baseline (in the absence of further consumption). 5-MeO-DMT does not have a cross-tolerance with other psychedelics, meaning that after the consumption of 5-MeO-DMT psychedelics will not have a reduced effect.

Dangerous interactions

Deaths from 5-MeO-DMT are rare but, as a powerful monoamine reuptake inhibitor (MRI), injury can occur when excessive doses are taken or when taken with drugs such as MAOIs, RIMAs, stimulants and any substance which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine. This has resulted in well documented deaths[11][12] that are easily avoidable and could have been otherwise prevented.

Legal status

  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[13]
  • Denmark: As of December 1, 2004, 5-MeO-DMT was legally restricted to "medical or scientific purposes".
  • Gemany: As of December 1, 2004, 5-MeO-DMT was legally restricted to "medical or scientific purposes".
  • Greece: 5-MeO-DMT became a controlled substance in Greece on February 18, 2003 [EU Legal Database].
  • Latvia: 5-MeO-DMT is a Schedule I drug.[14]
  • New Zealand: 5-MeO-DMT is Schedule I (Class A) in New Zealand.
  • Sweden: 5-MeO-DMT was classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as the "Act on the Prohibition of Certain Goods Dangerous to Health") in their regulation SFS 2004:696, making it illegal to sell or possess as of Oct 1, 2004.[15]
  • Switzerland: 5-MeO-DMT is Schedule I in Switzerland.
  • Romania: 5-MeO-DMT is illegal in Romania since February 2010.
  • USA: 5-MeO-DMT was added to Schedule I, effective January 19, 2011. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.[16]
  • United Kingdom - 5-MeO-DMT is a Class A drug in the UK as it is an ether of the drug 5-HO-DMT[17], which is a Class A drug as a result of the tryptamine catch-all clause.[18]
  • China - As of October 2015 5-MeO-DMT is a controlled substance in China.[19]

See also

External links

Literature

  • Ott, J. (2011). Pharntepena-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of, (October 2013), 37–41. https://doi.org/10.1080/02791072.2001.10399925
  • Shen, H.-W., Jiang, X.-L., Winter, J. C., & Yu, A.-M. (2010). Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions. Current Drug Metabolism, 11(8), 659–666. https://doi.org/10.2174/138920010794233495

References

  1. http://www.dmtsite.com/5-meo-dmt/information/traditional_use.html | Short summary of 5-MeO-DMT use among shamans
  2. Shen, H.-W., Jiang, X.-L., Winter, J. C., & Yu, A.-M. (2010). Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions. Current Drug Metabolism, 11(8), 659–666. https://doi.org/10.2174/138920010794233495
  3. Ott, J. (2011). Pharntepena-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of, (October 2013), 37–41. https://doi.org/10.1080/02791072.2001.10399925
  4. https://erowid.org/chemicals/5meo_dmt/5meo_dmt_health.shtml
  5. http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=38
  6. The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17013638
  7. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17223101
  8. Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20942780
  9. Phillips, Steven J. and Wentworth Comus, Patricia, ed. (2000). A Natural History of the Sonoran Desert. University of California Press. p. 537. ISBN 0-520-21980-5.
  10. http://www.erowid.org/archive/sonoran_desert_toad/erspamer.htm
  11. http://www.ncbi.nlm.nih.gov/pubmed/15214625
  12. http://www.ncbi.nlm.nih.gov/pubmed/16356341
  13. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  14. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (Triptamīni) | http://likumi.lv/doc.php?id=121086
  15. http://www.notisum.se/rnp/sls/sfs/20040696.pdf
  16. "DEA_FRDOC_0001-0076". 
  17. Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
  18. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
  19. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.