5-MeO-DMT

From PsychonautWiki
(Redirected from 5-meo-dmt)
Jump to: navigation, search
Dialog-warning.svg.png

5-MeO-DMT is not a substitute or alternative to DMT.

Despite what their names might suggest, 5-MeO-DMT and DMT have distinct effects and risk profiles. They should therefore be regarded as separate entities. Please see this this section for more information.

Summary sheet: 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT.svg
Chemical Nomenclature
Common names 5-MeO-DMT, "The Power"
Substitutive name 5-Methoxy-N,N-dimethyltryptamine
Systematic name 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold 1 - 3 mg
Light 3 - 6 mg
Common 6 - 12 mg
Strong 12 - 20 mg
Heavy 20 mg +
Duration
Total 20 - 40 minutes
Onset 5 - 60 seconds
Come up 30 - 60 seconds
Peak 5 - 15 minutes
Offset 10 - 20 minutes
After effects 15 - 60 minutes




Insufflated
Dosage
Threshold 3 - 5 mg
Light 5 - 8 mg
Common 8 - 15 mg
Strong 15 - 25 mg
Heavy 25mg+
Duration
Total 2 - 3 hours
Onset 1 - 10 minutes
Peak 10 - 40 minutes
Offset 30 - 60 minutes
After effects 1 - 3 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

5-Methoxy-N,N-dimethyltryptamine (commonly known as 5-MeO-DMT) is a naturally occurring psychedelic substance of the tryptamine class. As with its structural relatives DMT and 5-HO-DMT (Bufotenin), 5-MeO-DMT has been used as an entheogen by South American shamans for thousands of years.[citation needed]

It is distributed in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). It has also been shown to be produced endogenously in the human body in trace amounts, although its biological function is unclear.[1]

In modern times, 5-MeO-DMT is primarily acquired and consumed in its synthetic powder form through the use of online research chemical vendors. When taken in its synthetic powder form, 5-MeO-DMT is typically vaporized, but can also be insufflated (although this is discouraged), and is active at a dose of as little as 2 mg. It has been suggested that it possesses roughly 4-5x the potency of DMT.[2]

As with DMT, 5-MeO-DMT has been demonstrated to be active orally when taken with an MAOI, but according to numerous reports this combination tends to be extremely unpleasant, producing a strong "body load" in addition to the risk of hypertensive symptoms and serotonin syndrome, and is therefore strongly advised against.[3] On both physical and psychological levels, it is considered to be substantially less safe than DMT.[citation needed]

Anecdotal reports indicate that this substance is likely to be overly intense for those who are not already extensively experienced with hallucinogens, specifically powerful psychedelic tryptamines like DMT, ayahuasca and DPT. Therefore it is highly advised to approach this very unpredictable, and powerful hallucinogenic substance with the proper amount of precaution, preparation, and harm reduction practices if one chooses to use it.

Chemistry

Generic structure of a tryptamine molecule.

5-MeO-DMT or 5-methoxy-N,N-dimethyltryptamine is a ring-substituted indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. 5-MeO-DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT and 5-MeO-DiPT, although it radically differs in its effects.[4]

Pharmacology

Further information: Serotonergic psychedelic

5-Meo-DMT's psychedelic effects are primarily believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Specifically, this molecule shows high binding affinity for the 5-HT2A and 5-HT1A subtypes.[5] However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are also thought to be involved to an extent.[6] This can result in 5-MeO-DMT becoming dangerously toxic when combined with MAOIs, RIMAs, SSRIs, stimulants or any substance which acts as a releasing agent or reuptake inhibitor of monoamine neurotransmitters.

5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenin.[7]

Subjective effects

The physical effects of 5-MeO-DMT can be broken down into several components which progressively intensify proportional to dosage. In comparison to its often relatively mild accompanying cognitive and visual effects, 5-MeO-DMT seems to have by far the most proportionally intense and overwhelming physical sensations found within the known psychedelic experience. These individual components are complex, overwhelming and seem to be equally capable of being interpreted as either extremely pleasurable and euphoric or uncomfortable and dysphoric.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
Child.svg

Visual effects
Eye.svg

Transpersonal effects
Infinity4.svg

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Natural sources

Colorado River toad

Status iucn3.1 LC.svg.png

The Colorado River toad (Incilius alvarius), also known as the Sonoran Desert toad, is a toad found in northern Mexico and the southwestern United States. Its skin and venom contain 5-MeO-DMT and bufotenin (5-HO-DMT). Fresh venom can be collected without harm to the toad. This is done by stroking the parotid glands in the neck region onto a flat glass plate. The venom will take on the texture of rubber cement on drying, which can then be smoked. This product contains up to 15% 5-MeO-DMT, as well as 5-MeO-NMT and bufotenin.[citation needed]

Dosage

Assuming that an average of at least 10% of the venom is 5-MeO-DMT:

  • Threshold: 10 - 20 mg
  • Light: 20 - 50 mg
  • Common: 50 - 100 mg
  • Strong: 100 - 200 mg

Toxicity and harm potential

Ambulance2.png

This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational 5-MeO-DMT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 5-MeO-DMT has a limited history of documented human usage.

Anecdotal evidence suggests that there are unlikely to be any negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

Like other serotonergic psychedelics, 5-MeO-DMT is considered to be non-addictive with a low abuse potential. There are no literature reports of successful attempts to train animals to self-administer 5-MeO-DMT — an animal model predictive of abuse liability — indicating that it does not have the necessary pharmacology to either initiate or maintain dependence.

Tolerance to the effects of 5-MeO-DMT are built almost immediately after ingestion. After that, it takes about 1 hour for the tolerance to be reduced to half and 2 hours to be back at baseline (in the absence of further consumption). 5-MeO-DMT does not have a cross-tolerance with other psychedelics, meaning that after the consumption of 5-MeO-DMT psychedelics will not have a reduced effect.

Dangerous interactions

Deaths from 5-MeO-DMT are rare. However, as a powerful monoamine reuptake inhibitor (MRI),[8] injury can occur when excessive doses are taken or when taken with substances such as MAOIs, RIMAs, stimulants and anything which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine. This has resulted in well documented deaths[9][10] that could have been otherwise prevented.

Legal status

  • Austria: 5-Meo-DMT is, as an ether of N,N-DMT, illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).[citation needed]
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[11]
  • China: As of October 2015, 5-MeO-DMT is a controlled substance in China.[12]
  • Denmark: As of December 2004, 5-MeO-DMT is legally restricted to "medical or scientific purposes".[citation needed]
  • Gemany: As of December 1, 2004, 5-MeO-DMT is legally restricted to "medical or scientific purposes".[citation needed]
  • Greece: 5-MeO-DMT became a controlled substance in Greece on February 18, 2003 [EU Legal Database].[citation needed]
  • Latvia: 5-MeO-DMT is a Schedule I drug.[13]
  • New Zealand: 5-MeO-DMT is Schedule I (Class A) in New Zealand.[citation needed]
  • Romania: 5-MeO-DMT is illegal in Romania since February 2010.[citation needed]
  • Sweden: 5-MeO-DMT was classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as the "Act on the Prohibition of Certain Goods Dangerous to Health") in their regulation SFS 2004:696, making it illegal to sell or possess as of Oct 1, 2004.[14]
  • Switzerland: 5-MeO-DMT is Schedule I in Switzerland.[citation needed]
  • United Kingdom: 5-MeO-DMT is a Class A drug in the UK as it is an ether of the drug 5-HO-DMT,[15] which is a Class A drug as a result of the tryptamine catch-all clause.[16]
  • United States: 5-MeO-DMT was added to Schedule I, effective January 19, 2011. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.[17]

See also

External links

Discussion

Literature

  • Ott, J. (2011). Pharmepéna-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of 5-Methoxy-N, N-Dimethyl-Tryptamine. Journal of Psychoactive Drugs, 33(4), 403-407. https://doi.org/10.1080/02791072.2001.10399925
  • Shen, H.-W., Jiang, X.-L., Winter, J. C., & Yu, A.-M. (2010). Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions. Current Drug Metabolism, 11(8), 659–666. https://doi.org/10.2174/138920010794233495
  • Davis, A. K., Barsuglia, J. P., Lancelotta, R., Grant, R. M., & Renn, E. (2018). The epidemiology of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption. Journal of Psychopharmacology. https://doi.org/10.1177/0269881118769063

References

  1. Shen, H.-W., Jiang, X.-L., Winter, J. C., & Yu, A.-M. (2010). Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions. Current Drug Metabolism, 11(8), 659–666. https://doi.org/10.2174/138920010794233495
  2. Ott, J. (2011). Pharntepena-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of, (October 2013), 37–41. https://doi.org/10.1080/02791072.2001.10399925
  3. https://erowid.org/chemicals/5meo_dmt/5meo_dmt_health.shtml
  4. http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=38
  5. The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17013638
  6. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17223101
  7. Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20942780
  8. https://www.ncbi.nlm.nih.gov/pubmed/17223101
  9. http://www.ncbi.nlm.nih.gov/pubmed/15214625
  10. http://www.ncbi.nlm.nih.gov/pubmed/16356341
  11. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  12. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  13. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (Triptamīni) | http://likumi.lv/doc.php?id=121086
  14. http://www.notisum.se/rnp/sls/sfs/20040696.pdf
  15. Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
  16. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
  17. "DEA_FRDOC_0001-0076".