THJ-018

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Summary sheet: THJ-018
THJ-018
THJ-018.svg
Chemical Nomenclature
Common names THJ-018
Systematic name 1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold Common Heavy
- 1 - 2 - 3 - 5 mg
Light Strong
Threshold < 1 mg
Light 1 - 2 mg
Common 2 - 3 mg
Strong 3 - 5 mg
Heavy 5 mg +
Duration
Total 2 - 3 hours
Onset 5 - 10 minutes
Peak 60 - 90 minutes
Offset 5 - 10 minutes
After effects 60 - 90 minutes










DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

THJ-018 (1-​naphthalenyl(1-​pentyl-​1H-​indazol-​3-​yl)-​methanone) is a synthetic cannabinoid and analog of JWH-018. It has been marketed by many research chemical vendors as a legal alternative to the popular JWH-018, which had been banned in 2009. Its appearance is a brown, sticky and chunky powder. It smells very similarly to naphthalene. Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-018 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.

Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

Chemistry

THJ-018, or 1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone, is a synthetic cannabinoid containing a substituted indazole structure. THJ-018 is substituted at R1 with a pentyl chain. Additionally, the indazole core is substituted at R3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings. This carbonyl bridge of THJ-018 classifies it as a ketone. THJ-018 is an analog of JWH-018 in which the core indole structure is substituted with an indazole base.

Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.

Pharmacology

Although this substance has not been formally studied, from analysis of the structure, it is presumed that THJ-018 has a similar binding profile to that of JWH-018 and matches many of the in vivo properties of Δ9-THC. As with JWH-018, THJ-018 exhibits its range of effects via full agonism of both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. THJ-018 is around 5x the potency of Δ9-THC. However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Cognitive effects
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Auditory effects
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Combinational effects

  • Psychedelics - When used in combination with psychedelics, cannabinoids are capable of intensifying and extending the duration of both the visual and cognitive effects with extreme efficiency. This should be used with caution if one is not experienced with psychedelics.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced.
  • Alcohol - When used in combination with alcohol, cannabinoids can cause feelings of extreme nausea, dizziness and changes in gravity. It is recommended that one smokes before drinking and not the other way around unless they are extremely cautious.

Toxicity and harm potential

The toxicity and long-term health effects of recreational THJ-018 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because THJ-018 has very little history of human usage. Anecdotal evidence from people who have tried THJ-018 within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer large amounts of anxiety or to fall asleep.

It has often been recommended that those with severe pre-existing mental conditions should not ingest these substances due to the way they strongly increase one's current state of mind and emotions. Also, like THC, prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis[10], particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[11][12][13]

As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other synthetic cannibanoids, the chronic use of THJ-018 can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of THJ-018 develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). THJ-018 presents cross-tolerance with all cannabinoids, meaning that after the consumption of THJ-018 all cannabinoids will have a reduced effect.

Toxicity

Although there is no valid data on the toxicity of synthetic cannabinoids so far, there is concern that the naphthalene group found in THJ-018 and some other synthetic cannabinoids may be toxic or carcinogenic.[14][15][16][17]

Legal issues

THJ-018 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in most of the world.

  • United Kingdom - THJ-018 is a class B drug under the third-generation synthetic cannabinoids generic definition, which came into effect on the 14th December 2016 and is illegal to possess, produce, supply, or import. [18]
  • Latvia: THJ-018 is a Schedule I drug.[19]
  • Germany: THJ-018 is an Anlage II controlled drug in Germany.[20]
  • Sweden: THJ-018 is banned in Sweden.[21]

See also

External links

References

  1. Mechoulam, R. (1984). Cannabinoids as therapeutic agents. Boca Raton, FL: CRC Press. ISBN 0-8493-5772-1.
  2. How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm
  3. How Marijuana Works | http://science.howstuffworks.com/marijuana4.htm
  4. http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4637.2009.00703.x/abstract
  5. Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2011.03970.x/abstract
  6. Causal association between cannabis and psychosis: examination of the evidence - The British Journal of Psychiatry Jan 2004, 184 (2) 110-117 | http://bjp.rcpsych.org/content/184/2/110.short
  7. Every-Palmer, S. Synthetic cannabinoid use and psychosis: an explorative study. Journal of Drug and Alcohol Dependence 2011.
  8. “Spice” Girls: Synthetic Cannabinoid Intoxication - The Journal of Emergency Medicine Volume 40, Issue 3, March 2011, Pages 296–299 (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0736467910008802
  9. A Teenager With Agitation: Higher Than She Should Have Climbed - Pediatric Emergency Care: June 2010 - Volume 26 - Issue 6 - pp 462-465 | http://journals.lww.com/pec-online/Abstract/2010/06000/A_Teenager_With_Agitation__Higher_Than_She_Should.16.aspx
  10. Causal association between cannabis and psychosis: examination of the evidence - The British Journal of Psychiatry Jan 2004, 184 (2) 110-117 | http://bjp.rcpsych.org/content/184/2/110.short
  11. Every-Palmer, S. Synthetic cannabinoid use and psychosis: an explorative study. Journal of Drug and Alcohol Dependence 2011.
  12. “Spice” Girls: Synthetic Cannabinoid Intoxication - The Journal of Emergency Medicine Volume 40, Issue 3, March 2011, Pages 296–299 (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0736467910008802
  13. A Teenager With Agitation: Higher Than She Should Have Climbed - Pediatric Emergency Care: June 2010 - Volume 26 - Issue 6 - pp 462-465 | http://journals.lww.com/pec-online/Abstract/2010/06000/A_Teenager_With_Agitation__Higher_Than_She_Should.16.aspx
  14. http://www.epa.gov/ttn/atw/hlthef/naphthal.html
  15. Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/19464565
  16. Synthetic cannabinoids in herbal products (United Nations Office on Drugs and Crime) | https://www.unodc.org/documents/scientific/Synthetic_Cannabinoids.pdf
  17. http://hamiltonmorris.blogspot.co.uk/2010/06/napthalene-is-so-over.html
  18. The Misuse of Drugs Act 1971 (Amendment) Order 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2016/1109/made
  19. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (Indazola-3-karbonilatvasinājumi) | http://likumi.lv/doc.php?id=121086
  20. http://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html
  21. http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/