Talk:Fluorexetamine

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Fluorexetamine
Chemical Nomenclature
Common names	Fluorexetamine, FXE
Substitutive name	3-F-2′-Oxo-PCE
Systematic name	2-(Ethylamino)-2-(3-fluorophenyl)cyclohexan-1-one
Class Membership
Psychoactive class	Dissociative
Chemical class	Arylcyclohexylamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Insufflated Dosage Threshold 2.5 mg Light 5 - 15 mg Common 15 - 37.5 mg Strong 37.5 - 75 mg Heavy 75 mg + Duration Total 2 - 2.5 hours After effects 4 - 8 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Fluorexetamine (3'-Fluoro-2-oxo-PCE, FXE) is a recreational designer drug from the arylcyclohexylamine family. According to anecdotal reports fluorexetamine produces dissociative and analgesic effects and is described to be slightly more stimulating than ketamine.

History and culture

It is a new designer drug that has been reportedly sold over the internet since around 2017. In April 2023 it was revealed by DrugsData.org that all their previously analyzed samples of fluorexetamine actually contained 2'-Fluoro-2-oxo-PCE (2-FXE, also known as CanKet) rather than 3'-Fluoro-2-oxo PCE (3-FXE). This was confirmed by a newly available reference standard for 2-FXE. Similar misidentification may have occurred in other laboratories.

Chemistry

Fluorexetamine, or 2-(ethylamino)-2-(3-fluorophenyl)cyclohexan-1-one, is classed as an arylcyclohexylamine drug. Arylcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Deschloroketamine contains a phenyl ring with a 3'-Flouro substitution bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone) at R1. Bound to the adjacent alpha carbon (R2) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3.

Pharmacology

Due to the lack of research regarding the substance, all discussion regarding its pharmacology is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as ketamine, PCE and methoxetamine (3-MeO-2'-Oxo-PCE). While no scientific studies have been conducted to verify this, structure-activity relationship analysis suggests that Fluorexetamine likely exhibits its observed effects principally as an NMDA receptor antagonist, although other neurotransmitter systems may be involved.

NMDA receptors (a subtype of receptors for glutamate, which are the principle excitatory neurotransmitters in the nervous system) allow for electrical signals to pass between nerve cells in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists have been shown to disrupt this signaling by blocking these receptors. This disconnection of information flow in the nervous system leads to loss of sensation (anesthesia), difficulty moving (motor discoordination), and eventually this substance's equivalent of the “K-hole.”

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Changes in felt bodily form
  • Changes in felt gravity
  • Decreased libido - Unlike stimulants and many other substances, FXE tends to strongly decreases libido, making sexual activity unappealing and difficult to perform; coincides with tactile suppression and orgasm suppression.
  • Dizziness - Some users report dizziness while under the influence of FXE.
  • Difficulty urinating
  • Optical sliding - The user's eyes may wiggle and shake (a condition known as nystagmus), particularly at higher doses. This effect is temporary and usually not a cause for concern unless it persists after other effects have worn off.
  • Orgasm suppression - Strongly inhibits orgasms and the normal sexual arousal response at moderate to high doses.
  • Pain relief - Very prominent. Most physical sensations are suppressed on FXE.
  • Perception of bodily lightness - The user may feel as if the body is floating and has become entirely weightless. At low doses, this effect is reported to be oddly stimulating, promoting physical activity by making the body feel effortless to move.
  • Physical autonomy - Relatively uncommon, but may occur in some users. Users may feel as if their body is performing gestures and movements outside of their own control. However, these disturbances tend to be simple and short-lived.
  • Motor control loss - A loss of gross and fine motor control alongside balance and coordination is common and becomes pronounced at higher doses. Users are advised to be sitting during the onset in case they fall over and injure themselves.
  • Muscle relaxation
  • Perception of bodily heaviness
  • Perception of bodily lightness Physical euphoria
  • Pupil constriction
  • Stimulation
  • Tactile suppression - The sense of touch may be entirely suppressed, creating feelings of numbness within the extremities.
  • Dehydration
  • Difficulty urinating
  • Dry mouth
  • Frequent urination
  • Nausea
    • Vomiting
  • Optical sliding
  • Photophobia
  • Physical fatigue
  • Runny nose
  • Temporary erectile dysfunction
  • Vibrating vision

Visual effects

• The visual effects of fluorexetamine are highly suppressive and distortive. As a result, one should never drive or operate machinery while under the influence of fluorexetamine!

  Suppression

  • Acuity suppression
  • Double vision - Prevalent at moderate to heavy doses and can make reading text impossible unless closing one eye.
  • Frame rate suppression - Dose-dependent and prominent at higher doses.
  • Pattern recognition suppression - Generally occurs at higher doses and makes one unable to recognize and interpret perceivable visual data.

  Distortions

  • Perspective distortion
  • Scenery slicing

Cognitive effects

• • Amnesia
  • Analysis suppression - Users report that it is difficult to think normally or logically while under the influence of FXE. Normal cognition and working memory are impaired in a dose-dependent manner. However, the trade-off is that creative or non-linear thinking faculties may become enhanced (see conceptual thinking).
  • Anxiety suppression - Anxiety suppression is notable at all doses but not as selective as the effect of benzodiazepines or other GABAergics.
  • Cognitive euphoria - Users report moderate to strong states of cognitive euphoria which tend to occur during the come-up phase; however, appears to be less pronounced compared to stimulants, entactogens, and opioids.
  • Compulsive redosing - Due to its euphoric effects, rapid onset, and short duration, FXEcan cause compulsive re-dosing in some individuals. It is strongly advised to employ strategies to limit intake and prevent abuse.
  • Conceptual thinking - FXE produces conceptual or non-linear thinking in a manner that can stimulate one's artistic or creative faculties. Users commonly report entering dream-like, highly complex, and abstract mental spaces that frees them from the boundaries of normal cognition and promotes new insight into their lives and mental patterns.
  • Déjà vu - The user may experience a powerful sensation of déjà vu. This effect is uncommon but less-so than with other substances.
  • Delusion - Delusions appear to occur more commonly on FXE than other substances (e.g. stimulants, psychedelics). This effect often coincides with its ego inflation component. It is strongly advised to avoid FXE if you are susceptible to mental disorders like schizophrenia or bipolar disorder as it may exacerbate delusions and trigger psychosis.
  • Depersonalization & Derealization
  • Depression reduction
  • Disinhibition - Low doses produce disinhibition in a similar manner as alcohol. As a result, it is sometimes used for this purpose in parties and raves. Higher doses will result in the opposite effect: social withdrawal and inability to communicate normally.
  • Dream potentiation
  • Focus suppression - The ability to focus on a single task or object may be strongly suppressed. Its mental effect can be described as "scattering" and "non-linear"; occurs alongside analysis suppression.
  • Immersion enhancement - The user's sense of immersion may be significantly enhanced, particularly when viewing visual media. It is considered to be one of the most immersion-enhancing substances known.
  • Increased music appreciation - FXE may increase one's appreciation of music depending on dose and setting. However, this effect is generally less consistent than the effect of psychedelics or entactogens. Sometimes the opposite effect occurs, causing music to sound alien and unpleasant.
  • Introspection - Some user reports suggest FXE may enhance introspection; however, this effect appears to be much less consistent and robust than psychedelics and entactogens. It should be noted that there is limited evidence showing FXE has psychotherapeutic benefits.
  • Irritability
  • Memory suppression - Strongly suppresses short and long-term memory (in a dose-dependent manner) for the duration of the experience. Heavy doses appear to be able to temporarily turn off one's memory altogether and produce amnesia.
  • Personal bias suppression - Some user reports suggest FXE may suppress one's personal bias; however, this effect appears to be much less consistent and robust than the effect of psychedelics or entactogens.
  • Mania - As been reported on higher dose during the comedown
  • Spatial disorientation - Spatial orientation is very prominent and occurs in a dose-dependent manner. As a result, the user should carefully analyze any environment in which they are taking FXE to avoid becoming lost or injuring themselves.
  • Psychosis - Psychosis appear to be more common on FXE than other substances (e.g. stimulants, psychedelics) and appears to coincide with the delusion effect. It is strongly advised to avoid FXE if you are susceptible to mental disorders like schizophrenia or bipolar disorder as it may exacerbate delusions and trigger psychosis.
  • Suggestibility enhancement - The user may be rendered significantly more suggestible during and after FXE administration. This may be a result of FXE effect on cognition and susceptibility to delusions and psychosis.
  • Thought deceleration - Thoughts may be perceived by the user as if they are stiff, frozen, or in slow-motion. Dissociatives are known to produce this effect more strongly than other substances.
  • Time distortion - FXE prominently alters the subjective experience of time, particularly at the k-hole threshold. In this state, the user is rendered unable to tell how much time has passed; some users report that it can feel like an entire lifetime in the span of half an hour. Others report being transported to a dimension seemingly beyond time and space until the effects wear off.
  • Wakefulness - Compared to ketamine, FXE will keep you fully awake and it can be difficult to sleep on it.

Auditory effects

• • Auditory distortion
  • Auditory hallucinations
  • Auditory suppression

Disconnective effects

• • Cognitive disconnection
  • Physical disconnection
  • Visual disconnection - This eventually results in the experience of the notorious "k-hole" or, more specifically, holes, spaces and voids alongside of structures.

Multi-sensory effects

• • Synaesthesia - Synaesthesia is sometimes reported on FXE , especially at higher doses. Some users have reported the experience of being able to "hear colors" or "see sounds" in the k-hole state. However, it is not clear if FXE is capable of producing synaesthesia as a normal effect or if it is merely eliciting it in predisposed individuals. More research is needed to understand the causality of this reported effect.

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

• Erowid Experience Vaults: Fluorexetamine

Toxicity and harm potential

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Alcohol - Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
• Amphetamines - May increase mania.
• Cannabis - Cannabis majorly amplifies the sensory and cognitive effects. This interaction can also amplify the anxiety, confusion and delusion producing aspects of cannabis significantly. Those who choose to use this combination are advised to start off with only a fraction of their usual cannabis dose, and slow down the pace of their normal intake considerably.
• Dissociatives - Both synergise.
• Cocaine - May increase mania.
• GHB / GBL - Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
• Opioids - Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
• Tramadol - Tramadol lowers the seizure threshold. Both substances increase the risk of vomiting and unconsciousness.

External links

• Fluorexetamine (Wikipedia)

References

1. Wallach J, Brandt SD (2018). "1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances". New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 305–352. doi:10.1007/164_2018_148. ISBN 978-3-030-10560-0. PMID 30196446.

1. Erowid, DrugsData org /. "DrugsData.org (was EcstasyData): Test Details : Result #15191 - White Crystals, 15191". https://www.drugsdata.org/view.php?id=15191 & https://drugsdata.org/view.php?id=15292. Retrieved 2023-12-02.