Talk:Dextrorphan

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Summary sheet: Dextrorphan
Dextrorphan
Dextrorphan.svg
Chemical Nomenclature
Common names DXO
Substitutive name Dextrorphan
Systematic name (+)-17-methyl-9a,13a,14a-morphinan-3-ol
Class Membership
Psychoactive class Dissociative
Chemical class Morphinan
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 80 mg
Light 100 - 150 mg
Common 150 - 300 mg
Strong 300 - 450 mg
Heavy 450 mg+
Duration









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Dextrorphan (also known as DXO) is a dissociative drug of the morphinan class. It's the main active metabolite of dextromethorphan (DXM). It appears as a colorless powder.[1]

Chemistry

Dextrorphan is a dextrorotatory molecule of the morphinan class. It contains a phenanthrene core structure with one aromatic ring (benzene) bound to two saturated rings (cyclohexane). Dextromethorphan is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form Dextrorphan.[2]

Pharmacology

The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[3] DXO is an active chemical and contributes to the subjective effects experienced when active doses of DXM are consumed.[4]

Binding affinities (Ki)

  • NMDA antagonist - 486 nM
  • Sigma-1 agonist - 351 nM
  • Serotonin transporter (SERT) - 484 nM
  • Mu opioid agonist - 420 nM

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses are more likely to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.

One user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.[5]

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

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This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

Legal issues

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Germany: Dextrorphan is uncontrolled.[citation needed]
  • Poland: Dextrorphan is unscheduled.[6]
  • United States: Dextrorphan is unscheduled since October 1, 1976.[7]

See also

External links

References

  1. "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 | https://www.erowid.org/chemicals/dxm/dxm_info3.shtml
  2. Cytochrome P450-dependent metabolism of dextromethorphan: fetal and adult studies. | https://www.ncbi.nlm.nih.gov/pubmed/1306804
  3. Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study | http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract
  4. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders - 3. Pharmacodynamics (January 2016) | https://www.researchgate.net/publication/292212463_Dextromethorphan_An_update_on_its_utility_for_neurological_and_neuropsychiatric_disorders
  5. "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 | https://www.erowid.org/chemicals/dxm/dxm_info3.shtml
  6. List of scheduled substances in Poland. | http://www2.mz.gov.pl/wwwfiles/ma_struktura/docs/zal2_uopnarkomanii_29072005.pdf
  7. DEA: "Lists of: Scheduling Actions Controlled Substances Regulated Chemicals"