Talk:Dextrorphan

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Summary sheet: Dextrorphan
Dextrorphan
Dextrorphan.svg
Chemical Nomenclature
Common names DXO
Substitutive name Dextrorphan
Systematic name (+)-17-methyl-9a,13a,14a-morphinan-3-ol
Class Membership
Psychoactive class Dissociative
Chemical class Morphinan
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 80 - 100 mg
Light 100 - 150 mg
Common 150 - 300 mg
Strong 300 - 450 mg
Heavy 450 mg+
Duration









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Dextrorphan (also known as DXO) is a dissociative drug of the morphinan class. It's the main active metabolite of dextromethorphan (DXM). It appears as a colorless powder.[1]

Chemistry

Dextrorphan is a dextrorotatory molecule of the morphinan class. It contains a phenanthrene core structure with one aromatic ring (benzene) bound to two saturated rings (cyclohexane). Dextromethorphan is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form Dextrorphan.[2]

Pharmacology

The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.[3] DXO is an active chemical and contributes to the subjective effects experienced when active doses of DXM are consumed.[4]

Binding affinities (Ki)

  • NMDA antagonist - 486 nM
  • Sigma-1 agonist - 351 nM
  • Serotonin transporter (SERT) - 484 nM
  • Mu opioid agonist - 420 nM

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

One user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.[5]

Physical effects

Cognitive effects

Legal issues

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  • Germany: Not controlled
  • Poland: Unscheduled[6]
  • United States: Unscheduled since October 1, 1976.[7]

See also

External links

References

  1. "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 | https://www.erowid.org/chemicals/dxm/dxm_info3.shtml
  2. Cytochrome P450-dependent metabolism of dextromethorphan: fetal and adult studies. | https://www.ncbi.nlm.nih.gov/pubmed/1306804
  3. Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study | http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract
  4. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders - 3. Pharmacodynamics (January 2016) | https://www.researchgate.net/publication/292212463_Dextromethorphan_An_update_on_its_utility_for_neurological_and_neuropsychiatric_disorders
  5. "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 | https://www.erowid.org/chemicals/dxm/dxm_info3.shtml
  6. List of scheduled substances in Poland. | http://www2.mz.gov.pl/wwwfiles/ma_struktura/docs/zal2_uopnarkomanii_29072005.pdf
  7. DEA: "Lists of: Scheduling Actions Controlled Substances Regulated Chemicals"