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Summary sheet: N-Methylbisfluoromodafinil
Chemical Nomenclature
Common names N-Methylbisfluoromodafinil, Dehydroxyfluorafinil, Modafiendz
Substitutive name N-Methyl-4,4'-difluoro-modafinil
Systematic name 2-{[Bis(4-fluorophenyl)methyl]sulfinyl}-N-methylacetamide
Class Membership
Psychoactive class Stimulant / Eugeroic
Chemical class Benzhydryl
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 25 mg
Light 50 - 100 mg
Common 100 - 150 mg
Strong 150 - 200 mg
Heavy 200 mg +
Total 5 - 8 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


N-Methyl-4,4'-difluoro-modafinil (also known as N-Methylbisfluoromodafinil, Dehydroxyfluorafinil, and Modafiendz)[1] is an obscure nootropic of the benzhydryl class with no history of research. Although it is closely related on a structural level to adrafinil and modafinil, neither a pharmacological nor a safety-profile similarity should be assumed.


N-methyl-4,4-difluoro-modafinil, or 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-methylacetamide, is a synthetic molecule of the benzhydryl class. Benzhydryl compounds are comprised of two benzene rings attached to a single carbon molecule. N-methylbisfluoromodafinil contains a fluorine group bound to each benzene ring at R4. It is classified as a sulphinyl benzhydryl molecule, as it also contains a sulphinyl group, a sulfur molecule double-bonded to an oxygen molecule, attached to the carbon of the benzhydryl group. From this sulfur group at R2, an acetamide group is bound at its free carbon through a carbonyl group to an amine group. This terminal amine group is N-substituted with a methyl chain. N-methylbisfluoromodafinil is structurally similar to other benzhydryl stimulants modafinil and fluorafinil; it is the bis-fluoro-N-methyl analog of modafinil.

N-methylbisfluoromodafinil is the bis-fluoro-N-methyl analogue to modafinil; it contains two fluorine groups bound to each benzene ring at carbon 4 and an OH- (hydroxyl) group bound to the amine of modafinil.


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This pharmacology section is incomplete.

You can help by adding to it.

This compound has not been subject to any research, besides one paper discussing its chemical properties.[2] Even though a pharmacological similarity with modafinil can be assumed, pharmacological similarity to adrafinil and CRL-40,941 seems more likely.[2] This compound should not be assumed safe in any case, until further, though unlikely, research is conducted.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Toxicity and harm potential

The toxicity and long-term health effects of recreational N-methylbisfluoromodafinil use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because N-methylbisfluoromodafinil has very little history of human usage. Anecdotal evidence from people who have tried N-methylbisfluoromodafinil within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

The chronic use of N-methylbisfluoromodafinil can be considered as mildly addictive with a low potential for abuse and it does not seem to be capable of causing psychological dependence among certain users due to its lack of euphoria or recreational effects. If addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of N-methylbisfluoromodafinil develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).[citation needed] N-methylbisfluoromodafinil presents cross-tolerance with all modafanil analogs, meaning that after the consumption of N-methylbisfluoromodafinil all modafinil analogs will have a reduced effect.[citation needed]

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • 25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with N-Methylbisfluoromodafinil should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
  • Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
  • DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
  • MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
  • MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
  • Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
  • Stimulants - N-Methylbisfluoromodafinil may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
  • Tramadol - Tramadol is known to lower the seizure threshold[3] and combinations with stimulants may further increase this risk.
  • MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
  • MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.[4]
  • Cocaine - This combination may increase strain on the heart.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

N-methylbisfluoromodafinil is currently a gray area compound within most (if not all) parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analog laws and with intent to sell or consume.

  • United Kingdom - It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[5]

See also

External links


  1. CRL-40,941 - C15H13F2NO3S, ChemSpider 
  2. 2.0 2.1 Dowling, G., Kavanagh, P. V., Talbot, B., O’Brien, J., Hessman, G., McLaughlin, G., Twamley, B., Brandt, S. D. (March 2017). "Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog: Thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector". Drug Testing and Analysis. 9 (3): 518–528. doi:10.1002/dta.2142. ISSN 1942-7603. 
  3. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183. 
  4. Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210Freely accessible. eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647. 
  5. Psychoactive Substances Act 2016