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Summary sheet: 4-HO-DiPT
Chemical Nomenclature
Common names 4-HO-DiPT, Iprocin
Substitutive name 4-Hydroxy-N,N-diisopropyltryptamine
Systematic name 3-[2-(Dipropylamino)ethyl]-1H-indol-4-ol
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 3 mg
Light 3 - 10 mg
Common 10 - 20 mg
Strong 20 - 30 mg
Heavy 30 mg +
Total 2 - 4 hours
Onset 15 - 30 minutes
Come up 20 - 40 minutes
Peak 60 - 90 minutes
Offset 30 - 60 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


4-Hydroxy-diisopropyltryptamine (also known as 4-HO-DiPT and Iprocin) is a lesser-known psychedelic substance of the tryptamine class that produces psilocin-like psychedelic effects when administered. It is the 4-hydroxy analog of DiPT[1] and is structurally related to tryptamines like 4-HO-DMT (Psilocin), 4-HO-MiPT (Miprocin), and 4-HO-DET (Ethocin).

Following the publication of its synthesis by David B. Repke in 1977,[2] its effects in humans were investigated by Alexander Shulgin.[3] It is characterized in his 1997 book TiHKAL ("Tryptamines I Have Known and Loved") and is noted for being unique among psychedelics in terms of its speed (apparent 15 minutes after ingestion), intensity (20 milligrams can produce a transcendent peak experience), brevity (2-3 hours), and dose sensitivity. Additionally, idiosyncratic physical effects like muscle tremors and bodily malaise were noted.[4]

Today, 4-HO-DiPT is used for both recreational and entheogenic purposes. It is relatively uncommon and occasionally distributed on the online research chemical market. Very little is known about the pharmacological properties, metabolism, and toxicity in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.


4-HO-DiPT, or 4-Hydroxy-N,N-diisopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-DiPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains two isopropyl groups bound to the terminal amine RN of its tryptamine backbone.

4-HO-DiPT is a 4-hydroxy analog of DiPT and the N-substituted isopropyl homolog of 4-HO-DMT.


Further information: Serotonergic psychedelic

Like most psychedelic tryptamines, 4-HO-DiPT is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-HO-DiPT's binding efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

The effects listed below are based on the subjective effect index, which is based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will rarely (if ever) occur all at once but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 4-HO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DiPT is a research chemical with very little history of human usage.

Anecdotal reports from those who have tried 4-HO-DiPT suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-HO-DiPT is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-DiPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DiPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-DiPT all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when taken with other substances. The following lists some known dangerous combinations, but cannot be guaranteed to include all of them. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

  • Lithium - Lithium is commonly prescribed in the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis has an unexpectedly strong and unpredictable synergy with the effects of psychedelics. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid over intake.
  • Stimulants (Amphetamine, cocaine, methylphenidate, ...) - Stimulants affect many parts of the brain and alter dopaminergic function. Combined with psychedelics, stimulation can turn into severe anxiety, panic, thought loops, and paranoia. This interaction may result in an elevated risk of mania and psychosis.[citation needed]
  • Tramadol - Tramadol lowers the seizure threshold[5] and psychedelics may act as triggers for seizures in susceptible individuals.[citation needed]

Legal status

Due to its relative obscurity, the possession and sale of 4-HO-DiPT is unscheduled in most countries.

  • Germany: 4-HO-DiPT is controlled under the NpSG as of July 18, 2019. [6] [7] Production and import for placing on the market and trade is punishable. Possession, although illegal, is not penalized if not intended for sale.[8]
  • Sweden: 4-HO-DiPT is classified as a "health hazard" under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated to the "Act on the Prohibition of Certain Goods Dangerous to Health") as of March 1, 2005 in their regulation SFS 2005:26, making it illegal to sell or possess.[9]
  • United Kingdom: 4-HO-DiPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.[10]
  • United States: 4-HO-DiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.[citation needed]
    • Florida: 4-HO-DiPT is a Schedule I controlled substance in the state of Florida, making it illegal to buy, sell, or possess.[11]

See also

External links



  1. https://www.erowid.org/library/books_online/tihkal/tihkal17.shtml Entry in TIHKAL
  2. Repke, DB; Ferguson, WJ; Bates, DK. Psilocin analogs. 1. Synthesis of 3-[2-(dialkylamino)ethyl]- and 3-[2-(cycloalkylamino)ethyl]indol-4-ols. J. Heterocycl. Chem., 1 Jan 1977, 14 (1), 71–74. 273 kB. http://dx.doi.org/10.1002/jhet.5570140113 | http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570140113/abstract
  3. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p293 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
  4. Shulgin, A., & Shulgin, A. (1991). IsomerDesign: "TiHKAL" - #17 - 4-HO-DiPT. Retrieved Jan 22, 2018.
  5. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089
  6. https://www.buzer.de/gesetz/12250/v224771-2019-07-18.htm
  7. https://www.gesetze-im-internet.de/npsg/anlage.html
  8. https://www.gesetze-im-internet.de/npsg/__4.html
  9. http://www.notisum.se/rnp/sls/sfs/20050026.pdf
  10. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
  11. http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html