5-MeO-MiPT

Summary sheet: 5-MeO-MiPT

5-MeO-MiPT
Chemical Nomenclature
Common names	5-MeO-MiPT, "Moxy"
Substitutive name	5-Methoxy-N-methyl-N-isopropyltryptamine
Systematic name	N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-N-methylpropan-2-amine
Class Membership
Psychoactive class	Psychedelic / Entactogen
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. Smoked Dosage Threshold 5 mg Light 5 - 10 mg Common 10 - 15 mg Strong 15 - 20 mg Heavy 20 mg + Duration Total 5 - 8 hours Onset 20 - 60 minutes Peak 1 - 2 hours Offset 1 - 2 hours After effects 1 - 3 hours Oral Dosage Threshold 3 mg Light 3 - 7 mg Common 7 - 15 mg Strong 15 - 20 mg Heavy 20 mg + Duration Total 5 - 8 hours Onset 20 - 40 minutes Come up 30 - 60 minutes Peak 2 - 3 hours Offset 2 - 3 hours After effects 2 - 4 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Cannabis
Stimulants
Tramadol
Lithium

5-Methoxy-N-methyl-N-isopropyltryptamine (also known as 5-MeO-MiPT and moxy) is a lesser-known psychedelic substance of the tryptamine class. 5-MeO-MiPT is chemically related to tryptamines like 5-MeO-DMT and 5-MeO-DiPT. It produces its psychoactive effects through activity at serotonin receptors in the brain.

The synthesis and pharmacology of 5-MeO-MiPT was first reported in 1985 by David Repke and Alexander Shulgin.^[1] Its effects in humans was documented in Shulgin's book TiHKAL ("Tryptamines I Have Known and Loved").

Anecdotal reports describe 5-MeO-MiPT's effects as highly stimulating and mildly entactogenic, lacking in typical psychedelic visual distortions. Many users report strong physical and tactile effects that serve to enhance libido and sexual pleasure. An unpleasant "body load" is also often reported at common to high doses, marked by muscle tension and nausea.

Very little is known about the pharmacological properties, metabolism and toxicity of 5-MeO-MiPT, and it has a limited history of human use. It has been sold online as a research chemical. It is highly advised to use harm reduction practices when using this substance.

Chemistry

5-MeO-MiPT, or 5-methoxy-N-methyl-N-isopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 5-MeO-MiPT is substituted at R₅ of its indole heterocycle with a methoxy (MeO) functional group CH₃O−; it also contains a methyl group and an isopropyl chain bound to the terminal amine R_N of its tryptamine backbone (MiPT).

5-MeO-MiPT is the N-substituted isopropyl homologue of 5-MeO-DMT.^[2]

Pharmacology

5-MeO-MiPT's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist^[3][4] and additional mechanisms of action such as the inhibition of MAO (i.e. digestive enzymes in the stomach) have also been speculated upon, though this has yet to be demonstrated scientifically.

Subjective effects

5-MeO-MiPT can be taken via oral ingestion or it can be smoked. When ingested orally, the visual and sensory effects are reported to become more prominent. The experience can be broken up into two stages; the first half feels stimulating and entactogenic whilst the second half feels more similar to a traditional tryptamine psychedelic like psilocybin mushrooms or LSD. When smoked, the physically and cognitively stimulating effects become emphasized.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 5-MeO-MiPT

Toxicity and harm potential

The toxicity and long-term health effects of recreational 5-MeO-MiPT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 5-MeO-MiPT is a research chemical with very little history of human usage.

Anecdotal evidence from people within the community who have tried 5-MeO-MiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

5-MeO-MiPT is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 5-MeO-MiPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 5-MeO-MiPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 5-MeO-MiPT all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from Tripsit.

• Lithium - Lithium is commonly prescribed in the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis has an unexpectedly strong and unpredictable synergy with the effects of psychedelics. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid over intake.
• Stimulants (amphetamines, cathinones, cocaine, phenidates, etc.) - Stimulants affect many parts of the brain and alter dopaminergic function. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops, and paranoia. This interaction may result in an elevated risk of mania and psychosis.^{[citation needed]}
• Tramadol - Tramadol lowers the seizure threshold^[5] and psychedelics may act as triggers for seizures in susceptible individuals.^{[citation needed]}

There are no known deaths from 5-MeO-MiPT but, as a monoamine reuptake inhibitor (MRI)^[6], injury could occur when excessive doses are taken or when it is taken with drugs such as MAOIs, RIMAs, stimulants and any substance which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine.^[7]

2C-T-7 AMT Ayahuasca Harmala alkaloids 2-AI 2-FMA 3-FPM 4-FA A-PVP Amphetamine Cocaine Ethylphenidate

N-Methylbisfluoromodafinil Isopropylphenidate MDAI MDMA Mephedrone Methamphetamine Methiopropamine Methylone Methylphenidate Modafinil NM-2-AI Noopept

Legal status

• Brazil: 5-MeO-MiPT is illegal to produce, sell, or possess as it is listed on Portaria SVS/MS nº 344.^[8]
• China: 5-MeO-MiPT is controlled as a Category I psychotropic substance and is illegal to sell, buy, import, export, and manufacture.^[9]
• Finland: 5-MeO-MiPT was banned in Finland in December 2014.^[10]
• Japan: 5-MeO-MiPT is controlled as a "Designated Substance" (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell.^{[citation needed]}
• Latvia: 5-MeO-MiPT is a Schedule I drug in Latvia.^[11]
• New Zealand: 5-MeO-MiPT is an analogue of DMT which makes it a Class C controlled drug in New Zealand.^[12]
• Romania: 5-MeO-MiPT and other derivatives are illegal in Romania, as of January 2011.^{[citation needed]}
• United Kingdom: 5-MeO-MiPT is a Class A drug in the UK as it is an ether of the drug 5-HO-MiPT^[13], which is a Class A drug as a result of the tryptamine catch-all clause.^[14]
• United States: 5-MeO-MiPT is unscheduled in the United States. It may be considered an analogue of 5-MeO-DiPT, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.^{[citation needed]}
  • Florida: 5-MeO-MiPT is a Schedule I drug in Florida.^[15]
  • Louisiana: 5-MeO-MiPT is a Schedule I drug (as of June 2013).^[16]
  • Minnesota: Minnesota banned a series of drugs including 5-MeO-MiPT.^[17]

See also

• Responsible use
• Psychedelics
• Tryptamines
• 5-MeO-DMT

External links

• 5-MeO-MiPT (Wikipedia)
• 5-MeO-MiPT (Erowid Vault)
• 5-MeO-MiPT (TiHKAL / Isomer Design)

Discussion

• The Big & Dandy 5-MeO-MiPT Thread (Bluelight)

References