Talk:HXE

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This page has not been approved by the PsychonautWiki administrators.

It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks.

Summary sheet: HXE
HXE
HXE.svg
Chemical Nomenclature
Common names HXE
Substitutive name 3-HO-2'-Oxo-PCE
Systematic name 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one
Class Membership
Psychoactive class Dissociative
Chemical class Arylcyclohexylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability x% - y%[1]
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total x - y hours
Onset x - y minutes
Come up x - y minutes
Peak x - y hours
Offset x - y hours
After effects x - y hours


Sublingual
Dosage
Bioavailability x% - y%
Threshold x - mg
Light x - y mg
Common x - y mg
Strong x - y mg
Heavy x mg +
Duration
Total a - b hours
Onset a - b minutes
Come up a - b minutes
Peak a - b hours
Offset a - b hours
After effects a - b hours







DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.



3-HO-2'-Oxo-PCE (commonly known as HXE) is a dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered. It is structurally related to Methoxetamine,Ketamine and PCE.

Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.

History and culture

HXE first appeared for sale on the online research chemical market in late 2020.

Chemistry

HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine

Pharmacology

Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

Subjective effects

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This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.

Physical effects
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Visual effects
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Cognitive effects
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Auditory effects
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Multi-sensory effects
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Transpersonal effects
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Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational HXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because HXE has very little history of human usage.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Tolerance and addiction potential

Dangerous interactions

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This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

External links

HXE

Literature

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References

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References