Talk:Bromazolam
For chemistry section: Although the name might suggest that Bromazolam is the triazolobenzodiazepine derivate of bromazepam, that would actually be pyrazolam. As such, bromazolam could be considered to be named bromodeschloroalprazolam instead.
PsychonautWiki desperately needs an informative, accurate Bromazolam article
I would do it but this is my first time editing a Wiki. I will help in any way possible Battleboner (talk) 19:30, 3 April 2023 (UTC)
Bromazolam information in the article and Discussion section is in some cases wildly underplayed. Article should be quarantined while we figure out wtf is going on here. Bromazolam is a powerful alprazolam analogue almost mg per mg as powerful.
Bromazolam information in the article and Discussion section is in some cases wildly underplayed. Article should be quarantined while we figure out wtf is going on here. Bromazolam is a powerful alprazolam analogue almost mg per mg as powerful.
Bromazolam Dosage guidlines and duration of effects from fairly recent WHO Critical Review report
Page 8 of their reports on ROA's and dosage seemed most particularly helpful.
Light dosage range is reported to be: (05mg-1mg) Common dosage range is reported to be: (1mg-2mg) Strong/heavy dosage range is reported to be:(2mg-4mg)
"Onset of effects after oral use is estimated to be 15–45 min, and the duration of action is 5–8 h." - WHO Critical Review findings
This Could use a page By Now
This substance is fairly popular now, because of law reasons.
Its effects seem almost identical to Alprazolam, so does the dosage and the predicted binding seems to match the experienced effects (from what i can understand of the reports, and talking to some people on harm reduction communities)
https://tripsit.me/factsheets/bromazolam https://www.drugsinfo.nl/overige-middelen/bromazolam https://cdn.who.int/media/docs/default-source/46th-ecdd/bromazolam_46th-ecdd-critical-review_public-version.pdf?sfvrsn=4f1bccfa_1
Like Pyrazolam/Alprazolam there are some early concerning reports regarding, re-reenforcing and withdrawal effects https://drugsforum.nl/threads/bromazolam.67875/post-1692592 This could be entirely because of the pharmakinetic effects (fast absorption rate and short duration)
There is a single piece of animal research
The abuse potential of bromazolam at 0.1–3 mg/kg was evaluated in male rats trained to discriminate the benzodiazepine midazolam in a standard two-lever drug discrimination study (29). Like midazolam and diazepam, bromazolam resulted in full dose-dependent substitution for the 0.3 mg/kg training dose of midazolam, with an ED50 (± 95% confidence interval [CI]) of 0.54 (0.26 ; 1.12) mg/kg. In comparison, the ED50 (± 95% CI) was 0.09 (0.06; 0.14) mg/kg for midazolam and 0.66 (0.40 ; 1.12) mg/kg for diazepam. At the dose range tested, bromazolam did not affect response rates. The midazolam-like effects of bromazolam at 3 mg/kg were significantly attenuated by pre-administration of the benzodiazepine receptor antagonist flumazenil at 1 mg/kg. Morphine, tested as a negative control, did not produce a response on the midazolam-associated lever at doses that suppressed the overall response rate.
Single experience report
https://www.erowid.org/experiences/exp.php?ID=115168
Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569319/ https://en.wikipedia.org/wiki/Bromazolam
Sadly no human research on these substances exist, but it seems to me that the research about predicting the binding efficient of certain benzo analogs was simply too successful to require anything else for recreational use, this should just be a simple Halogenic substitution of Aprazolam and it seems to behave exactly as expected.
Also don’t understand why Bromazolam doesn’t have its own page, since it’s a very popular RC benzo.
It’s my pet rats favorite. My rat told me, it’s very close to Alprazolam in Dosage & also high.
Biggest difference is, it is a ”clearer“ high. It doesn’t fog up your brain, like Alprazolam does. Kenz0r (talk) 21:28, 12 March 2024 (UTC)