Talk:Agmatine

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Summary sheet: Agmatine

Agmatine
Chemical Nomenclature
Common names	DMT, Dimethyltryptamine, Dmitri
Substitutive name	N,N-Dimethyltryptamine
Systematic name	2-(1H-Indol-3-yl)-N,N-dimethylethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Bioavailability x% - y% Threshold x - mg Light x - y mg Common x - y mg Strong x - y mg Heavy x mg + Duration Total x - y hours Onset x - y minutes Come up x - y minutes Peak x - y hours Offset x - y hours After effects x - y hours ⇣ Sublingual Dosage Bioavailability x% - y% Threshold x - mg Light x - y mg Common x - y mg Strong x - y mg Heavy x mg + Duration Total a - b hours Onset a - b minutes Come up a - b minutes Peak a - b hours Offset a - b hours After effects a - b hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

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History and culture

This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

Agmatine acts as an NMDA receptor antagonist, a2 adrenergic receptor antagonist, and imidazoline receptor agonist.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• If applicable, a brief paragraph summary of the substance's physical effects may be included here. You may select physical effects to add below here.
  • Pain relief
  • Stimulation or Sedation - Some individuals experience mild stimulation from agmatine, while others report mild sedation
  • Nausea - This effect is more prominent at high doses
  • Stomach bloating - This effect is more prominent at high doses
  • Vasodilation - Agmatine is shown to be a potent vasodilator, and is commonly supplemented by body builders for this purpose
  • Physical euphoria
  • Muscle relaxation
  • Hypogylcemia

Visual effects

• If applicable, a brief paragraph summary of the substance's visual effects may be included here. You may select visual effects to add below here.

  Enhancements

  • Visual acuity effect1

  Distortions

  • Visual distortion effect1

  Geometry

  If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.

  Hallucinatory states

  If applicable, a brief summary of the substance's visual effects profile may be written here.

  • Hallucinatory states1

Cognitive effects

• If applicable, a brief paragraph summary of the substance's cognitive effects may be included here. You may select from a list of cognitive effects to add below here.
  • Psychosis - Increased blood agmatine is associated with psychosis, and the administration of agmatine increases cognitive markers of psychosis , however it is unlikely in regular doses to produce psychotic symptoms in healthy individuals
  • Anxiety suppression
  • Motivation enhancement
  • Addiction suppression - Agmatine has shown to have remarkable efficacy in reducing the withdrawal symptoms of several different classes of addictive substances, as well as reducing addictive behaviors
  • Empathy, affection, and sociability enhancement - This effect is milder when compared to substances such as MDMA
  • Emotion enhancement - Agmatine is anecdotally reported to enhance positive emotions and reduce anhedonia, however some users report mild anhedonia from taking agmatine
  • Dream potentiation
  • Cognitive euphoria - This effect is milder in comparison to other dissociatives such as DXM
  • Increased music appreciation
  • Increased libido or Decreased libido
  • Insomnia - Agmatine produces insomnia in some individuals when taken late in the day

Auditory effects

• If applicable, a brief paragraph summary of the substance's auditory effects may be included here. You may select from a list of auditory effects to add below here.
  • Auditory effect1
  • Auditory effect2

Multi-sensory effects

• If applicable, a brief paragraph summary of the substance's multisensory effects may be included here. You may select from a list of multisensory effects to add below here.
  • Multisensory effect1
  • Multisensory effect2

Transpersonal effects

• If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here. You may select from a list of transpersonal effects to add below here.
  • Transpersonal effect1
  • Transpersonal effect2

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

• Erowid Experience Vaults: SUBSTANCE

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Dangerous interactions

This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

• Responsible use

External links

(List along order below)

• SUBSTANCE (Wikipedia)
• SUBSTANCE (Erowid Vault)
• SUBSTANCE ([PiHKAL or TiHKAL] / Isomer Design)

Literature

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