Talk:Agmatine

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Summary sheet: Agmatine

Agmatine
Chemical Nomenclature
Common names	Agmatine
Systematic name	N-Anisoyl-2-pyrrolidinone
Class Membership
Psychoactive class	Nootropic
Chemical class	Aminoguanidine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 150 mg Light 250 - 500 mg Common 500 - 1000 mg Strong 1000 - 2500 mg Heavy 2500 mg + Duration Total 3 - 6 hours Onset 30 - 60 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

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History and culture

This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

Pharmacology

This pharmacology section is incomplete. You can help by adding to it.

Agmatine acts as an NMDA receptor antagonist, a2 adrenergic receptor antagonist, and imidazoline receptor agonist.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• The primary physical effects of agmatine include noticeable vasodilation; It also acts as an analgesic, specifically reducing chronic and nerve-related pain. Because it suppresses adrenaline, it can cause a mild decrease in resting blood pressure and heart rate. Additionally, it can stimulate a moderate increase in appetite. If taken in excessively high doses, the main physical consequence is gastrointestinal distress.
  • Pain relief
  • Stimulation or Sedation - Some individuals experience mild stimulation from agmatine, while others report mild sedation
  • Nausea - This effect is more prominent at high doses
  • Stomach bloating - This effect is more prominent at high doses
  • Vasodilation - Agmatine is shown to be a potent vasodilator, and is commonly supplemented by body builders for this purpose
  • Physical euphoria
  • Muscle relaxation
  • Hypogylcemia

Cognitive effects

• Cognitively, agmatine primarily acts as a mood stabilizer and anxiolytic. It noticeably reduces background anxiety and stress by dampening the body's fight-or-flight response, which often results in a clearer, calmer mental state. It is used to alleviate anhedonia and restore a sense of baseline well-being without causing any intoxicating high. Additionally, it provides long-term cognitive neuroprotection.
  • Psychosis - Increased blood agmatine is associated with psychosis, and the administration of agmatine increases cognitive markers of psychosis , however it is unlikely in regular doses to produce psychotic symptoms in healthy individuals
  • Anxiety suppression
  • Motivation enhancement
  • Addiction suppression - Agmatine has shown to have remarkable efficacy in reducing the withdrawal symptoms of several different classes of addictive substances, as well as reducing addictive behaviors
  • Empathy, affection, and sociability enhancement - This effect is milder when compared to substances such as MDMA
  • Emotion enhancement - Agmatine is anecdotally reported to enhance positive emotions and reduce anhedonia, however some users report mild anhedonia from taking agmatine
  • Dream potentiation
  • Cognitive euphoria - This effect is milder in comparison to other dissociatives such as DXM
  • Increased music appreciation
  • Increased libido or Decreased libido
  • Insomnia - Agmatine produces insomnia in some individuals when taken late in the day

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

• Erowid Experience Vaults: SUBSTANCE

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

It is recommended that one use harm reduction practices when using this substance.

Lethal dosage

The median lethal dosage (LD50) of Agmatine has not been officially published.

Dangerous interactions

This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

• Responsible use

External links

(List along order below)

• Agmatine (Wikipedia)

Literature

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