|Summary sheet: DiPT|
|Routes of Administration|
N,N-Diisopropyltryptamine (also known as DiPT) is a lesser-known psychedelic substance of the tryptamine class. It is a structural analog of DMT and related to various psychedelic tryptamines such as 4-HO-DiPT, 5-MeO-DiPT, and MiPT.
The first human trials of DiPT were undertaken in 1975 by Alexander Shulgin, who would co-author and publish a paper detailing its synthesis and human psychopharmacology in 1981. A summary of the synthesis and reports of human use is included in Shulgin's 1997 book TiHKAL ("Tryptamines I Have Known And Loved"). It has been sold online as a research chemical.
While most psychedelics are known for producing vivid visual distortions, DiPT's effects are reported to be primarily auditory in nature. Anecdotal reports have described it causing a downward shift in perceived pitch and other unusual distortions. It has been suggested that DiPT may have value in neurological research due to its unique effects on auditory perception. Additional subjective effects of DiPT include a body high, moderate euphoria, mild visuals, dizziness, and nausea.
Very little data exists about the pharmacological properties, metabolism, and toxicity of DiPT, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Research
- 5 Toxicity and harm potential
- 6 Legal status
- 7 See also
- 8 External links
- 9 References
DiPT, or N,N-diisopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain.
DiPT also contains two isopropyl groups bound to the terminal amine RN of its tryptamine backbone. Isopropyl groups are a three carbon (propyl) chain bound at the middle carbon to the chemical structure. DiPT has substituted analogues such 5-MeO-DiPT.
The psychedelic effects of DiPT are believed to come from its efficacy at the 5-HT2A receptor. However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.
|This subjective effects section is a stub.|
As such, it is still in progress and may contain incomplete or wrong information.
You can help by expanding or correcting it.
Although DiPT's effects are primarily auditory, some users have reported lack of coordination or balance, stomach bloating, confusion, and visual distortions at higher doses. Aside from these, the most prevalent non-auditory effect is inner ear pressure (which has been painful in some instances such as when combined with MDMA).
Disclaimer: The effects listed below are cited from the subjective effect index, which is based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy degree of skepticism. It is worth noting that these effects will rarely (if ever) occur all at once, although higher doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
There is much speculation as to the nature of DiPT's aural distortion. At lower dosages, it has been reported to have an effect similar to a flanging, or a phase shift. At medium and higher dosages, the effect of DiPT is typically a radical shift downward in perceived pitch. This shift also tends to be nonlinear in that the shift downwards varies in relation to the initial pitch, for example, higher pitches are not lowered as much as already low pitches. This can produce bizarre sounds and render music disharmonious or unrecognizable
These auditory effects of DiPT are very apparent in their occurrence and exhibit a full range of effects which commonly includes:
- Auditory enhancement
- Auditory distortion
- Auditory hallucination
- Tinnitus - This is more common in quiet areas or is exaggerated whilst yawning. It does not necessarily hurt in the ears and the pitch and frequency are not as high and constant.
- Ear pressure - This effect is generally mild but has been painful in some cases.
- The sensory effects of DiPT are mostly auditory, however may still produce visual effects, in a similar fashion to other serotonergic psychedelics, especially at higher dosages These effects can include:
- The auditory effects of DiPT can last many times longer than it's cognitive, physical or visual effects. The auditory effects can also be retained for longer periods of time in a similar fashion to how one can not as easily forget something that has already been seen. Common after effects include:
There are currently no anecdotal reports which describe the effects of this compound within our experience index.
Additional experience reports can be found here:
One experiment involving subjects with perfect pitch indicated that there is no clear relationship between perceived pitch and actual pitch.
Although recent unpublished research has examined the role of DiPT in hearing perception in rodents, it is not clear that the auditory effect is preserved in nonhuman species; this finding indicates that DiPT does not produce effects similar to other tryptamine psychedelics such as DPT and 5-MeO-DMT in acoustic startle reflex paradigms. DiPT still remains widely unexplored.
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
The toxicity and long-term health effects of recreational DiPT do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DiPT is a research chemical with very little history of human usage.
Anecdotal reports from those who have tried DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this drug.
Dependence and abuse potential
DiPT is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of DiPT are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DiPT presents cross-tolerance with all psychedelics, meaning that after the consumption of DiPT all psychedelics will have a reduced effect.
- Germany: DiPT is controlled under the NpSG as of July 18, 2019.   Production and import for placing on the market and trade is punishable. Possession, although illegal, is not penalized if not intended for sale.
- Latvia: DiPT is a Schedule I drug.
- New Zealand: DiPT is an analogue of DMT, so is a Class C controlled drug in New Zealand.
- United Kingdom: DiPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
- United States: DiPT is unscheduled in the United States. It may be considered an analogue of DET, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.
- Florida: DiPT is a Schedule I controlled substance in the state of Florida. It is illegal to buy, sell, or possess.
- Shulgin, Alexander. "Pharmacology Lab Notes #1". Lafayette, CA. (1960-1976). p177 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook1_searchable.pdf
- Shulgin, AT; Carter, MF. N,N-diisopropyltryptamine (DIPT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT). Two orally active tryptamine analogs with CNS activity. Commun. Psychopharmacol., 1 Jan 1981, 4 (5), 363–369 | https://www.ncbi.nlm.nih.gov/pubmed/6949674
- Shulgin, Alexander (1997). TiHKAL: Tryptamines I Have Known and Loved. Berkeley, CA USA: Transform Press. pp. 403–406. ISBN 0-9630096-9-9.
- Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (Triptamīni) | http://likumi.lv/doc.php?id=121086
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
- The 2015 Florida Statutes | http://leg.state.fl.us/statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html