From PsychonautWiki
Jump to navigation Jump to search
Summary sheet: TMA
Chemical Nomenclature
Common names TMA, TMA-1, mescalamphetamine, α-Methylmescalin, AMM, EA-1319
Substitutive name 3,4,5-Trimethoxyamphetamine
Systematic name 1-(3,4,5-Trimethoxyphenyl)propan-2-amine
Class Membership
Psychoactive class Psychedelic / Stimulant
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 40 - 70 mg
Light 70 - 140 mg
Common 140 - 170 mg
Strong 170 - 200 mg
Heavy 200 mg +
Total 6 - 12 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


3,4,5-Trimethoxyamphetamine (also known officially as TMA or also referred to as TMA-1) is a synthethic psychedelic substance that produces a mixture of psychedelic, entactogenic and stimulant effects when administered. It is a member of the amphetamine class of compounds and a member of the TMA-x family of trimethoxylated amphetamines which also include compounds such as TMA-2 and TMA-6.

TMA first appeared in 1947.[1] It was the first synthethic psychedelic to be produced. It further found use in military chemical warfare studies but was abandonned without reports of the study being published[2]

TMA is the amphetamine homologue of mescaline, with it being closely related, its effects are said to be quite less profound and vastly more netural and bland in its nature when compared with mescaline.

In modern times, TMA is used as an obscure recreational drug and a occasional entheogen. It is rarely sold on the streets and is almost exclusively obtainable as a grey area research chemical through the use of online vendors.

Depending on the dose, this substance can produce unpredictable effects such as a strong body load, muscle tension and overstimulation. It is recommended to use harm reduction practises when choosing to use this substance.


TMA, or 3,4,5-trimethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines, being comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. TMA contains methoxy functional groups CH3O- attached to carbons R3, R4 and R5 of the amphetamine backbone.[3]

It is therefore the alpha-methylated homolog of mescaline.


Pill bottle-o.png

This pharmacology section is incomplete.

You can help by adding to it.

Further information: Serotonergic psychedelic

TMA's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Visual effects

Cognitive effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

Toxicity studies in humans have showed that excessive TMA doses induced hostility and manic states in users.[4]

The toxicity and long-term health effects of recreational TMA use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA suggest that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

TMA is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of TMA are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). TMA presents cross-tolerance with all psychedelics, meaning that after the consumption of TMA all psychedelics will have a reduced effect.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Switzerland: TMA is a controlled substance specifically named as an isomer of TMA-2 and TMA-6, both under Verzeichnis D.[5]
  • United Kingdom: TMA is a controlled Class A drug under the Misuse of Drugs Act 1977 and is covered by the generic definition (TMA is a positional isomer of the UN controlled drug TMA-2).[citation needed]

See also

External links