Talk:Oxazepam

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Fatal overdose may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Summary sheet: Oxazepam

Oxazepam
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Chemical Nomenclature
Common names	Oxazepam, Serax, Ceresta
Substitutive name	Oxazepam
Systematic name	(RS)-7-Chlor-3-hydroxy-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2
Class Membership
Psychoactive class	Depressant
Chemical class	Benzodiazepine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold < 10 mg Light 10 - 15 mg Common 15 - 25 mg Strong 30 - 45 mg Heavy 45 mg + Duration Total 8 - 12 hours Onset 30 - 60 minutes Come up 2 - 3 hours Peak 6 - 8 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Depressants
Dissociatives
Stimulants

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Sedation - In terms of energy level alterations, this drug is considerably unique in that it tends to be notably less sedating and less inebriating than other classical or standard benzodiazepines such as alprazolam, clonazepam, and lorazepam. In some sense, it may be seen by many users as more “relaxing” in terms of description rather than being thoroughly “sedating” in average doses (10 - 15mg). However, at sufficient enough doses sedation does become a salient and unavoidable effect at a certain point. Therefore, presumably at stronger doses this causes users to feel extreme somnolence, forcing them to sit down as they tend to generally feel as if they are constantly on the verge of passing out instead of being physically mobile or consciously alert. This component increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
  • Muscle relaxation - In comparison to alprazolam (Xanax), Oxazepam results in a greater degree of muscle relaxation.
  • Motor control loss
  • Respiratory depression
  • Dizziness - This symptom is usually much less prevalent compared to typical, (“heavier”) benzodiazepines like clonazepam or lorazepam.
  • Seizure suppression
  • Physical euphoria

Visual effects

• • Visual acuity suppression

Paradoxical effects

• Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, loss of impulse control, irritability and suicidal behavior sometimes occur (although they are rare in the general population, with an incidence rate below 1%).

  These paradoxical effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.

Cognitive effects

• The most prominent of these cognitive effects generally include:
  • Anxiety suppression - Less pronounced than with alprazolam, especially in regards to panic attacks but may have an upper-hand on many other benzodiazepines in this department due to a very lightly euphoric and subtle, but not uncommon comfortable sense of well-being that is not usually associated with other benzodiazepines.
  • Disinhibition
  • Delusions of sobriety - This is the false belief that one is perfectly sober despite obvious evidence to the contrary such as severe cognitive impairment and an inability to fully communicate with others. It most commonly occurs at heavy dosages.
  • Thought deceleration
  • Analysis suppression
  • Amnesia
  • Memory suppression - Oxazepam primarily suppresses short-term memory, resulting in forgetfulness, and/or disorganized behaviors.
  • Increased music appreciation
  • Compulsive redosing
  • Emotion suppression
  • Motivation suppression
  • Language suppression

After effects

• • Rebound anxiety - Rebound anxiety is a commonly observed effect with anxiety relieving substances like benzodiazepines. It typically corresponds to the total duration spent under the substance's influence along with the total amount consumed in a given period, an effect which can easily lend itself to cycles of dependence and addiction.
  • Dream potentiation or Dream suppression
  • Residual sleepiness - While benzodiazepines can be used as an effective sleep-inducing aid, their effects may persist into the morning afterward, which may lead users to feeling "groggy" or "dull" for up to a few hours.
  • Thought deceleration
  • Thought disorganization
  • Irritability

Toxicity and harm potential

Bromazepam has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose.

Lethal dosage

Depends on the Individual

Tolerance and addiction potential

Strong Physical and Psychological addiction potential

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before= consumption.

• Depressants (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
• Dissociatives - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
• Stimulants - It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

Legal status

Internationally, oxazpeam is a Schedule IV controlled drug under the Convention on Psychotropic Substances. Bromazepam is regulated in most countries as a prescription drug.

See also

• Responsible use

External links

(List along order below)

• (Wikipedia)
• (Drugs.com)