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2,5-dimethoxy-4-cyclopropylphenethylamine (also known as 2C-cP) is a lesser-known novel psychedelic substance of the phenethylamine class. 2C-cP is a very obscure member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Very little is known about the compound, and precautions should be used during its consumption. The precise mechanism is not fully understood, but it is likely due to its binding of serotonin receptors in the brain.
2C-cP was first synthesized and tested in 2006 by Daniel Trachsel and colleagues, the reports of which were documented in the book Phenethylamine: Von der Strucktur zur Funktion. Subjective effects of the compound were not listed in the publication.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-cP. It is strongly advised to use harm reduction practices if using this substance. These include avoiding "eye-balling" (i.e. measuring the dose with the naked eye instead of a reliable milligram scale) and non-oral routes of administration. Volumetric liquid dosing is commonly recommended when dealing with substances of this potency.
2C-cP or 2,5-dimethoxy-4-cyclopropylphenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-cP contains methoxy functional groups CH3O- attached to carbons R2 and R5 and a cyclopropyl chain attached to carbon R4 of the phenyl ring. 2C-cP belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.
According to Daniel Trachsel and colleagues, 2C-cP has a binding affinity (Ki) of 95 nM at the serotonin receptor 5-HT2A and 41 nM at 5-HT2C. Any effects in the body are likely to be done as a result of this mechanism. Based on this and the effects of other 2C-x compounds it likely has hallucinogenic effects, with minor stimulant properties. The dosage was listed at 15 and 35 mg with a duration of 3 to 6 hours.
2C-cP has no reports of human use, meaning any form of subjective effects could not be determined. Any effects present would likely be similar to ones found in similar compounds, such as others in the 2C-x family.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Anecdotal reports which describe the effects of this compound within our experience index include:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
The toxicity and long-term health effects of recreational 2C-cP use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-cP is a research chemical with very little to no history of human usage. Because of this, it is strongly recommended that one use harm reduction practices when using this substance.
The LD50 of 2C-cP has not been established, meaning caution should be used concerning the dosing of this substance.
Dependence and abuse potential
As a serotonergic psychedelic, 2C-cP is considered to have a low potential for abuse and dependence.
Tolerance to the effects of 2C-cP is unknown, but is likely similar to other 2C-x compounds, meaning tolerance is probably built immediately following ingestion, almost immediately after ingestion. Additionally, 2C-cP would likely produce cross-tolerance with all psychedelics, meaning that after the consumption of 2C-cP all psychedelics will have a reduced effect for a period of time, likely a week, and vice versa.
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
- Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2C-cP. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
- Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
- Tramadol - Tramadol is well-documented to lower the seizure threshold and psychedelics may act to trigger seizures in susceptible individuals.
2C-cP is not scheduled under the UN Convention on Psychotropic Substances. It is considered to exist in a legal grey area in many countries, meaning that while it is not specifically illegal, individuals may still be charged for its possession under certain circumstances such as under analog laws and with the intent to sell or consume.
- ↑ https://en.wikipedia.org/wiki/2C-CP
- ↑ Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. ISSN 1556-9039.