|Summary sheet: Theobromine|
Theobromine (3,7-dimethyl-1H-purine-2,6-dione or xantheose) is a bitter, white stimulant drug of the xanthine class that is closely related to caffeine. It is one of the main metabolites of caffeine and is the main alkaloid of theobroma cacao and its preparations: cocoa and chocolate. It is similar to caffeine in both its chemical structure and effects but weaker in its antagonism of adenosine receptors.
- 1 History and culture
- 2 Chemistry
- 3 Pharmacology
- 4 Subjective effects
- 5 Toxicity and harm potential
- 6 Legal status
- 7 See also
- 8 External links
- 9 Literature
- 10 References
History and culture
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Theobromine's pharmacology is very similar to the pharmacology of caffeine. Like caffeine, theobromine mainly functions as an adenosine receptor antagonist, and also acts as a non-selective inhibitor of phosphodiesterase (PDE).
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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature which relies on collected anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.
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- Stimulation - Theobromine induces stimulation similar to, but weaker than the stimulation induced by caffeine.
- Frequent urination
- Cough suppression
- Decreased blood pressure
- Increased heart rate - The myocardial stimulant effects of theobromine are greater than the effects caused by caffeine.
- Increased perspiration
- Stamina enhancement
- Tactile enhancement
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There are currently no anecdotal reports which describe the effects of this compound within our experience index.
Toxicity and harm potential
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It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
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Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
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