|Summary sheet: Adrafinil|
|Common names||Adrafinil, Olmifon|
|Systematic name||(±)-2-Benzhydrylsulfinylethanehydroxamic acid|
|Routes of Administration|
Adrafinil (also known as Olmifon) is a prodrug for modafinil - a wakefulness-promoting agent (eugeroic) with nootropic effects. Adrafinil is metabolized in the liver to produce modafinil. Both are stimulants with no amphetamine-like effects. Safety information on adrafinil is lacking because modafinil is often used instead, for treatment of narcolepsy and excessive daytime sleepiness. Long-term supplementation of adrafinil is not advised, since adrafinil is metabolized into modafinil in the liver, and may stress the liver through elevated liver enzymes with prolonged use.
Adrafinil is very structurally similar to its close chemical cousin and bioactive metabolite, modafinil. The only structural difference is that terminal amide hydroxyl group of adrafinil ((diphenylmethyl)sulﬁnyl-2 acetohydroxamic acid) is lacking in modafinil (diphenylmethyl)sulﬁnyl-2 acetamide).
The mechanism of adrafinil appears to rely on postsynaptic α-adrenergic activity since an increase in locomotion caused by adrafinil is blocked by prazosin (α1 antagonist), yohimbine (α2 antagonist), or phenoxybenzamine (mixed α-antagonist). These increases through adrenergic neurotransmission are thought to be responsible for adrafinil's energetic properties.
Orally ingested adrafinil may undergo one of two metabolic results. The main metabolite is the active modafinil, which is itself metabolized to the inactive modafinilic acid, then modafinil sulfone. Adrafinil, however, can also be metabolized to inactive modafinilic acid without conversion to modafinil.  This may account for its lower potency.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Toxicity and harm potential
The long-term safety and effectiveness of modafinil (adrafinil's active component) as a drug of regular usage have not been determined. Anecdotal reports from people who have tried modafinil within the community suggest that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
Adrafinil is more harmful than modafinil due to slight hepatotoxicity, as adrafinil must be processed by the liver. Stomach pain, skin irritation, anxiety, and elevated liver enzymes may occur with prolonged use and have been associated with Adrafinil, specifically.
It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
The chronic use of adrafinil can be considered as not addictive with a low potential for abuse. It does not seem to be capable of causing psychological dependence among most users.
Tolerance to many of the effects of adrafinil develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Adrafinil may present a cross-tolerance with all benzhydryl nootropics, meaning that after the consumption of adrafinil, all related eugeroic compounds such as armodafinil and modafinil will display a reduced effect.
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- Adrafinil: A Novel Vigilance Promoting Agent | http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.1999.tb00100.x/abstract
- A possible alpha-adrenergic mechanism for drug (CRL 40028)-induced hyperactivity. | https://www.ncbi.nlm.nih.gov/pubmed/228945
- High-performance liquid chromatographic determination of modafinil and its two metabolites in human plasma using solid-phase extraction. | https://www.ncbi.nlm.nih.gov/pubmed/9551816
- Pharmacotherapy for excessive daytime sleepiness | http://www.smrv-journal.com/article/S1087-0792(04)00024-3/abstract
- Modafinil: past, present and future. | https://www.ncbi.nlm.nih.gov/pubmed/19810941