From PsychonautWiki
Jump to: navigation, search

This article is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.


This article requires proofreading.

As such, it may contain incorrect grammar, spelling, or punctuation.

Summary sheet: Haloperidol
Chemical Nomenclature
Common names Haldol
Substitutive name Haloperidol
Systematic name 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Class Membership
Psychoactive class Antipsychotic
Chemical class Butyrophenone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold Common Heavy
0.25 - 0.25 - 1 - 5 - 10 mg
Light Strong
Bioavailability 60-70%
Threshold 0.25 mg
Light 0.25 - 1 mg
Common 1 - 5 mg
Strong 5 - 10 mg
Heavy 10 mg +
Total 12 - 36 hours
Onset 30 - 60 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Haloperidol (trade name Haldol) is an antipsychotic drug used to treat a variety of mental disorders, such as schizophrenia, mania, bipolar disorder, delirium, psychosis, Tourette syndrome, as well as other symptoms. It was first synthesized in 1958 by Paul Janssen[1] from meperidine[2]. Haloperidol is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[3] It is also one of the most frequently prescribed typical antipsychotics and is sometimes carried by medical services as an emergency sedative.



This chemistry section is incomplete.

You can help by adding to it.

Haloperidol is a molecule of the butyrophenone class.


Pill bottle-o.png

This pharmacology section is incomplete.

You can help by adding to it.

As a typical antipsychotic, haloperidol has a diverse pharmacological profile. Primarily, haloperidol acts on dopamine D2 receptors as an antagonist, as well as a D3 inverse agonist. Haloperidol is also an antagonist of the 5-HT2A receptor, although this effect is not as powerful as that of quetiapine. Unlike many antipsychotcs, haloperidol has negligible affinity for the muscarinic acetylcholine receptors as well as the histamine receptors, which results in less sedation, weight gain and hypotension.[4]

Subjective effects

This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

Haloperidol can have serious side effects at higher dosages, such as risk of having severe extrapyramidal symptoms and muscle rigidity, which can last for hours.

Both typical and atypical antipsychotics can cause tardive dyskinesia.[5] According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.[6] Switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.[7]

It is strongly recommended that one use harm reduction practices when using this drug.

Legal issues

  • Australia: The drug is available via prescription only.
  • Canada: The drug is available via prescription only.
  • United States: The drug is available via prescription only.
  • United Kingdom: Haloperidol is a prescription-only medication.

See also

External links