Haloperidol

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Haloperidol
Molecular structure of Haloperidol
Haloperidol.svg
Chemical Nomenclature
Common names Haldol
Substitutive name Haloperidol
Systematic name 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Class Membership
Psychoactive class Antipsychotic
Chemical class Butyrophenone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Bioavailability 60-70%
Threshold 0.25 mg
Light 0.25 - 1 mg
Common 1 - 5 mg
Strong 5 - 10 mg
Heavy 10 mg +
Duration
Total 12 - 36 hours
Onset 30 - 60 minutes









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: Haloperidol

Haloperidol (trade name Haldol) is an antipsychotic drug used to treat a variety of mental disorders, such as schizophrenia, mania, bipolar disorder, delirium, psychosis, Tourette syndrome, as well as other symptoms. It was first synthesized in 1958 by Paul Janssen[1] from meperidine[2]. Haloperidol is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[3] It is also one of the most frequently prescribed typical antipsychotics and is sometimes carried by medical services as an emergency sedative.

Chemistry

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Haloperidol is a molecule of the butyrophenone class.

Pharmacology

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As a typical antipsychotic, haloperidol has a diverse pharmacological profile. Primarily, haloperidol acts on dopamine D2 receptors as an antagonist, as well as a D3 inverse agonist. Haloperidol is also an antagonist of the 5-HT2A receptor, although this effect is not as powerful as that of quetiapine. Unlike many antipsychotcs, haloperidol has negligible affinity for the muscarinic acetylcholine receptors as well as the histamine receptors, which results in less sedation, weight gain and hypotension.[4]

Subjective effects

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects

Cognitive effects

Toxicity and harm potential

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We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

Haloperidol can have serious side effects at higher dosages, such as risk of having severe extrapyramidal symptoms and muscle rigidity, which can last for hours.

Both typical and atypical antipsychotics can cause tardive dyskinesia.[5] According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.[6] Switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.[7]

It is strongly recommended that one use harm reduction practices when using this drug.

Legal issues

  • Australia: The drug is available via prescription only.
  • Canada: The drug is available via prescription only.
  • United States: The drug is available via prescription only.
  • United Kingdom: Haloperidol is a prescription-only medication.

See also

External links

References

  1. https://books.google.ca/books?id=Cb6BOkj9fK4C&pg=PA124#v=onepage&q&f=false
  2. https://books.google.ca/books?id=iDNy0XxGqT8C&pg=PA62#v=onepage&q&f=false
  3. http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf
  4. H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs | http://www.nature.com/npp/journal/v28/n3/full/1300027a.html
  5. Tardive dyskinesia and new antipsychotics | http://journals.lww.com/co-psychiatry/pages/articleviewer.aspx?year=2008&issue=03000&article=00012&type=abstract
  6. Tardive dyskinesia and new antipsychotics | http://journals.lww.com/co-psychiatry/pages/articleviewer.aspx?year=2008&issue=03000&article=00012&type=abstract
  7. Tardive Dyskinesia | http://link.springer.com/article/10.1007%2Fs11940-011-0117-x