Methaqualone

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Death may occur when GABAergic substances are combined with other depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or alcohol.[1]

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Summary sheet: Methaqualone


Methaqualone
Methaqualone.svg
Chemical Nomenclature
Common names Methaqualone, Quaaludes, "Ludes", Mandrax, Sopor
Substitutive name Methaqualone
Systematic name 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
Class Membership
Psychoactive class Depressant
Chemical class GABAergic
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold 50 mg
Light 50 - 100 mg
Common 100 - 200 mg
Strong 200 - 300 mg
Heavy 300 mg +
Duration
Total 1 - 2 hours
Oral
Dosage
Threshold 75 - 150 mg
Light 150 - 300 mg
Common 300 - 500 mg
Strong 500 - 600 mg
Heavy 600 mg +
Duration
Total 5 - 8 hours
Onset 30 minutes
Come up 30 minutes
Peak 2 - 4 hours
Offset 2 - 4 hours
After effects 6 - 8 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Methaqualone (brand name Quaalude in the US and Mandrax in the UK) is a central nervous system (CNS) depressant of the quinazolinone class that acts as a sedative and hypnotic. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.[2] Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.

Chemistry

Methaqualone, or 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, is a compound of the quinazolinone class. Quinazolinone is a bicyclic structure containing a phenyl ring bound to another six-membered ring with two nitrogen members and a ketone group bound to R4. In methaqualone, this structure is substituted at R2 with a methyl group. Additionally, methaqualone contains a phenyl ring with a methyl group bound to R2 which is attached to the quinazolinone structure at R3.

Pharmacology

Despite prior speculation, a 2015 study demonstrates that methaqualone exhibits distinct functional properties at the GABA receptor sites compared with other allosteric modulators, and it mediates these through a different mechanism than the barbiturates and benzodiazepines that it historically has been lumped together with.[3]

These distinctions could contribute to the reported differences in the in vivo effects induced by methaqualone and classic CNS depressants. In any case, the multifaceted functionality of methaqualone at GABA A receptors seems to be at the root of its clinical efficacy, as well as the addiction liability and recreational use associated with the drug.[3]

It could be speculated that despite differences in targeted receptors, methaqualone essentially produces a variety of effects by binding to its receptor sites and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation would explain the resulting sedating or calming effects which ensue.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Overdose of methaqualone can lead to seizures, coma or death. Taking doses of over 300mg can be dangerous for first time users. Depending on the state of the user's individual tolerance, doses of about 8,000mg per day can be fatal whilst others on even higher doses (of up to 20,000mg) may survive.

Although the exact lethal dosage of methaqualone has not been formally established, like many depressants, it is safe at appropriate dosages. Complications may arise when administered in excess or in combination with other depressants.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

Methaqualone is extremely addictive. Tolerance to the sedative-hypnotic effects develops within a couple of days of repeated administration. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Methaqualone presents cross-tolerance with all gabaergic depressants, meaning that after the consumption of methaqualone all compounds of the same class will have a reduced effect.

Abrupt discontinuation of methaqualone following regular dosing over several days can result in a withdrawal phase which includes rebound symptoms such as increased anxiety and insomnia. It is possible to gradually reduce the dose over the course of several days, which will lengthen the duration of the withdrawal period but reduce the perceived intensity.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume.

  • Stimulants - It can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

Legal status

  • Australia - Methaqualone is Schedule 9 in Australia, meaning it is illegal without a license and deemed to have no medical value.
  • Austria - Methaqualone is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Canada - Methaqualone is Schedule III in Canada, meaning it requires a prescription or license to legally possess.
  • Germany - Methaqualone is Schedule III in Germany.
  • United Kingdom - Methaqualone is a Class B drug.
  • United States - Methaqualone is a Schedule I drug, and is illegal to possess without a license.[4]

See also

External links

References

  1. Risks of Combining Depressants (Tripsit) | https://tripsit.me/combining-depressants/
  2. US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones
  3. 3.0 3.1 A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude) (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/26056160
  4. http://www.drugs.com/article/csa-schedule-1.html