Caffeine/Summary
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Harm potential
Tolerance
Harm potential
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- Produces dependence with chronic use and has a low abuse potential
- The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated to be about 150 to 200 milligrams per kilogram of body mass or roughly 80 to 100 cups of coffee for an average adult
Tolerance
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- Full tolerance is reached develops with prolonged and repeated use
- Decreases to half after 3 - 7 days
- Returns to baseline after 1 - 2 weeks
- Cross-tolerance with antagonists adenosine receptors