2-Fluorodeschloroketamine

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Summary sheet: 2-Fluorodeschloroketamine
2-Fluorodeschloroketamine
Molecular structure of 2-FDK
2-Fluorodeschloroketamine.png
Chemical Nomenclature
Common names 2-Fluoroketamine, Fluoroketamine, 2-FK, 2-FDCK
Substitutive name 2-Fl-2'-Oxo-PCM
Systematic name (R/S)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.






Insufflated
Dosage
Threshold 5 - 10 mg
Light 10 - 60 mg
Common 20 - 60 mg
Strong 60 - 100 mg
Heavy 100 mg +
Duration
Total 4 - 6 hours
Onset 15 - 45 minutes
Come up 45 - 90 minutes
Peak 1.5 - 2.5 hours
Offset 1 - 1.5 hours
After effects 4 - 48 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2-Fl-2'-Oxo-PCM (also known as 2-Fluorodeschloroketamine, 2-FDCK, and inaccurately as 2-Fluroketamine, Fluoroketamine, and 2-FK) is a novel synthetic dissociative substance of the arylcyclohexylamine chemical class.[1] It produces dissociative, anesthetic, and hallucinogenic effects similar to those of ketamine when administered.

Like other dissociative substances of its class such, as ketamine and methoxetamine, it is primarily sought by recreational users for its ability to induce a hallucinogenic "out of body" state referred to as "dissociative anesthesia" (although the extent to which this occurs is highly dose-dependent). It has recently become available through online research chemical vendors where it is being sold as a designer drug replacement for ketamine.[2]

There is very little information on the pharmacology, metabolism or toxicity of 2-fluorodeschloroketamine. It has an extremely brief history of human use. It is strongly advised to use harm reduction practices if choosing to use this substance.

Chemistry

2-Fluorodeschloroketamine, or 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, is classed as an arylcyclohexylamine drug. Arylcyclohexylamines drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 2-FDCK contains a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH3) is bound to the adjacent alpha carbon (R2) of the cyclohexanone ring. Additionally, the phenyl ring is substituted at R2 with a fluorine group.

2-Fluorodescholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case "chloro") hence 2-FDCK is named for containing a fluorine substitution at its phenyl ring rather than the chlorine which is found in ketamine.

Pharmacology

Further information: NMDA receptor antagonist

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as DCK and ketamine. With this in mind, 2-Fluorodeschloroketamine is thought to act as an NMDA receptor antagonist.

NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”

Subjective effects

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As such, it may contain incomplete or wrong information and is still in progress.

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.


Toxicity and harm potential

The toxicity and long-term health effects of recreational 2-Fluorodeschloroketamine use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2-Fluorodeschloroketamine has very little history of human usage. Anecdotal evidence from people who have tried 2-Fluorodeschloroketamine within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of 2-Fluorodeschloroketamine can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 2-Fluorodeschloroketamine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 2-Fluorodeschloroketamine presents cross-tolerance with all dissociatives, meaning that after the consumption of 2-Fluorodeschloroketamine all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 2-Fluorodeschloroketamine seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because 2-Fluorodeschloroketamine is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

  • Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
  • Urinary urgency - This can be described as a sudden, compelling need to urinate.
  • Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
  • Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
  • Hematuria - Hematuria is visible blood in the urine.
  • Incontinence - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using 2-Fluorodeschloroketamine on a daily or even weekly basis and manually limiting one's usage of the substance.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Prominent examples include PCP and its analogs 3-MeO-PCP, MXE, and the diarylethylamine dissociatives like diphenidine or ephenidine. There is also evidence that suggests that combining these two increases their neurotoxicity.[citation needed] Anecdotally, worsened comedowns are also commonly reported when these two classes of substances are combined.
  • Depressants - Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

Legality

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As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Canada - This substance is covered by a blanket ban in Canada.[citation needed]
  • Latvia - 2-Fluorodeschloroketamine is illegal in Latvia.[3]
  • United Kingdom - 2-Fluorodeschloroketamine is a class B drug in the UK and is illegal to possess, produce, supply, or import. As an N-alkyl derivative of 2-Amino-2-phenylcyclohexanone substituted in the phenyl ring with a halide substituent, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.[4]

See also

External links

References

  1. Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative | http://www.tandfonline.com/doi/abs/10.1080/00397911.2014.885053#.VxH5USZVK1E
  2. The Big & Dandy 2-Fluoroketamine Thread | hhttp://www.bluelight.org/vb/threads/776753-The-Big-amp-Dandy-2-Fluoroketamine-Thread
  3. http://www.vm.gov.lv/images/userfiles/metodiskas_vadlinijas_080914.doc
  4. The Misuse of Drugs Act 1971 (Amendment) Order 2013 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2013/239/introduction/made