|Summary sheet: Ropinirole|
Duration: 4 to 8 hours, drug onset within first hour
History and culture
Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease. It was developed as a successor to pramipexole, with the aim of reducing side effects common to dopamine agonists. The FDA approved ropinirole for the treatment of Parkinson's disease in 1997, and it has been frequently prescribed off-label for the treatment of restless legs syndrome as well as extrapyrimidal symptoms, sexual dysfunction, and anhedonia associated with SSRI treatment.
Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. It is weakly active at 5-HT2 and α2 receptors, and is said to have virtually no affinity for 5-HT1, GABA, mAChR, α1, or β-adrenoreceptors.
Ropinirole is metabolized primarily by cytochrome P450 CYP1A2 to form two metabolites; SK&F-104557 and SK&F-89124, both of which are renally excreted, and at doses higher than clinical, is also metabolized by CYP3A4. At doses greater than 24 mg, CYP2D6 may be inhibited, although this has been tested only in vitro.
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Toxicity and harm potential
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It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
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Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
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